Advances in protein chemistry and structural biology, Journal Year: 2024, Volume and Issue: unknown, P. 191 - 269
Published: Nov. 16, 2024
Language: Английский
Annals of the Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 83(12), P. 1603 - 1613
Published: Aug. 6, 2024
For three-quarters of a century, glucocorticoids (GCs) have been used to treat rheumatic and autoimmune diseases. Over these 75 years, our understanding GCs binding nuclear receptors, mainly the glucocorticoid receptor (GR) their molecular mechanisms has changed dramatically. Initially, in late 1950s, were considered important regulators energy metabolism. By 1970s/1980s, they characterised as ligands for hormone-inducible transcription factors that regulate many aspects cell biology physiology. More recently, impact on cellular metabolism rediscovered. Our cell-type-specific GC actions crosstalk between various immune stromal cells arthritis models evolved by investigating conditional GR mutant mice using Cre/LoxP system. A major achievement studying complex, interplay is recent advent omics technologies at single-cell resolution, which will provide further unprecedented insights into types mediating responses. Alongside gene-encoded factors, anti-inflammatory metabolites participate resolving inflammation during are just being uncovered. The translation this knowledge therapeutic concepts help tackle inflammatory diseases reduce side effects. In review, we describe milestones preclinical research led current action years after first use arthritis.
Language: Английский
Citations
4
Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 20, 2025
Sepsis can trigger systemic inflammation and lead to detrimental effects on several organs, with particular emphasis the lungs. In sepsis-associated lung injury, macrophages assume a pivotal role, as their overactivation could facilitate secretion of inflammatory factors imbalance polarization. Hepatocyte nuclear factor 4 alpha (HNF4A) has been reported its potential involvement in regulation response macrophage This study discusses role mechanism HNF4A sepsis-induced damage. exhibits decrease expression by analyzing differentially expressed genes lungs septic mice from Gene Expression Omnibus dataset GSE15379. Then, we established mouse sepsis model through cecal ligation puncture method observed that was reduced both tissues alveolar macrophages. To evaluate function HNF4A, overexpressed mediated adenovirus vectors, which were injected into mice. We found overexpression resulted higher survival rate an amelioration pulmonary Meanwhile, mitigated infiltration cells impeded M1 polarization but facilitated M2 or lavage fluid. vitro, treated bone marrow-derived interleukin-4. Consistent results obtained promoted Mechanistically, transcriptionally regulate receptor coactivator 2 (NCOA2) binding promoter region. NCOA2 interacted glucocorticoid (GR). Stabilin 1 (STAB1) selected possible target transcriptome sequencing analysis. Functional experiments confirmed STAB1 downstream HNF4A/NCOA2/GR axis. Overall, this research investigated impact injury sepsis. It is suggested one regulatory mechanisms involved association may be NCOR2/GR/STAB1
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 748, P. 151327 - 151327
Published: Jan. 13, 2025
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 7, 2025
Nuclear Receptors (NRs) comprise a superfamily of proteins with essential roles in cell signaling, survival, proliferation, and metabolism. They act as transcription factors are subclassified into families based on their ligands, DNA-binding sequences, tissue specificity, functions. Evidence indicates that infectious diseases, cancer, autoimmunity, NRs modulate immune endocrine responses, altering the transcriptional profile cells organs influencing disease progression. Chronic characterized by pathogen persistence, particularly notable for an exaggerated inflammatory process. Unlike acute inflammation, which helps host respond to pathogens, chronic inflammation leads metabolic disorders dysregulated neuro-immuno-endocrine response. Over time, disturbances cytokine, hormone, other compound production foster unbalanced, detrimental defensive This complexity underscores significant role ligand-dependent NRs. Tuberculosis Chagas Disease two critical infections. The causative agents, Mycobacterium tuberculosis Trypanosoma cruzi , have developed evasion strategies establish Their clinical manifestations associated disrupted immuno-endocrine pointing potential involvement review explores current understanding regulating immune-endocrine interactions within context Disease. These diseases remain global health concerns, developing countries, highlighting importance molecular mechanisms underlying host-pathogen mediated
Language: Английский
Citations
0
Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown
Published: March 24, 2025
Language: Английский
Citations
0
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 1, 2024
Language: Английский
Citations
1
Vitamins and hormones, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0
Advances in protein chemistry and structural biology, Journal Year: 2024, Volume and Issue: unknown, P. 191 - 269
Published: Nov. 16, 2024
Language: Английский
Citations
0