Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy DOI Creative Commons
Virginia Gao, Julita Chlebowicz, Kerry Gaskin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 1, 2025

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease other synucleinopathies is thought to be tightly linked vesicle binding. Age the biggest risk factor for synucleinopathy, ~15% proteins have been central nervous system diseases. Yet, age- disease-induced changes vesicles remain unexplored. Via systematic analysis at ultrastructural, protein, lipid levels, we reveal specific populations, proteins, lipids over age wild-type mice α-synuclein knockout with without expression human α-synuclein. Strikingly, find several previously undescribed lacking α-synuclein, suggesting that loss contributes dysfunction. These findings not only provide insights into biology mechanisms but also serve as a baseline further mechanistic exploration disease-related alterations

Language: Английский

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy DOI Creative Commons
Virginia Gao, Julita Chlebowicz, Kerry Gaskin

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 1, 2025

Neurotransmitter release occurs through exocytosis of synaptic vesicles. α-Synuclein's function and dysfunction in Parkinson's disease other synucleinopathies is thought to be tightly linked vesicle binding. Age the biggest risk factor for synucleinopathy, ~15% proteins have been central nervous system diseases. Yet, age- disease-induced changes vesicles remain unexplored. Via systematic analysis at ultrastructural, protein, lipid levels, we reveal specific populations, proteins, lipids over age wild-type mice α-synuclein knockout with without expression human α-synuclein. Strikingly, find several previously undescribed lacking α-synuclein, suggesting that loss contributes dysfunction. These findings not only provide insights into biology mechanisms but also serve as a baseline further mechanistic exploration disease-related alterations

Language: Английский

Citations

0