Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: March 25, 2025
Abstract Recent research has shifted the focus from genetic code of DNA to its structural variations, which significantly impact cancer, diseases, and gene regulation. Structural changes, such as transition B-DNA A-DNA, influence stability flexibility are affected by factors like methylation sugar puckering. This study is first investigate relationship between conformational changes lifespan in two rodent species. The analysis focused on long-lived Nannospalax xanthodon shorter-lived Rattus rattus , utilizing infrared spectroscopy principal component (PCA) examine liver DNA. Results indicated that B-form A- Z-forms were more prevalent N. than R. . However, dominant conformations both species B-form. Additionally, N-type puckers (C3-endo conformation), associated with these forms, prominent In contrast, S-type (C2-endo characteristic B-DNA, found at lower levels Furthermore, variations methylation-specific modifications nucleobases quantitatively assessed among proposes a significant connection long live underground, their unique structure, offering insights into how different well backbone sugar-base components, may affect longevity, highlighting potential avenues regarding biomolecular aspects aging.
Language: Английский