Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives DOI Creative Commons
Michael W. Nestor, Richard L. Wilson

Organoids, Journal Year: 2025, Volume and Issue: 4(2), P. 9 - 9

Published: May 1, 2025

The development of brain organoids from human-induced pluripotent stem cells (iPSCs) has expanded research into neurodevelopment, disease modeling, and drug testing. More recently, the concept organoid intelligence (OI) emerged, proposing that these constructs could evolve to support learning, memory, or even sentience. While this perspective driven enthusiasm in field suggested new applications fields such as neuromorphic computing, it also introduces significant scientific conceptual concerns. Current lack anatomical complexity, network organization, sensorimotor integration necessary for Despite this, claims surrounding OI often rely on oversimplified interpretations neural activity, fueled by neurorealist reification biases misattribute neurophysiological properties biologically limited systems. Beyond limitations, framing risks imposing ethical regulatory challenges based speculative concerns rather than empirical evidence. assumption might possess sentience, develop over time, lead unnecessary restrictions legitimate while misrepresenting their actual capabilities. Additionally, comparing biological systems silicon-based computing overlooks fundamental differences scalability, efficiency, predictability, raising questions about whether can meaningfully contribute computational advancements. must recognize limitations models prematurely defining a distinct domain. A more cautious, evidence-driven approach is ensure remain valuable tools neuroscience without overstating potential. To maintain credibility public trust, essential separate narratives grounded research, thus allowing continued progress studies reinforcing misconceptions

Language: Английский

Assessing the Utility of Organoid Intelligence: Scientific and Ethical Perspectives DOI Creative Commons
Michael W. Nestor, Richard L. Wilson

Organoids, Journal Year: 2025, Volume and Issue: 4(2), P. 9 - 9

Published: May 1, 2025

The development of brain organoids from human-induced pluripotent stem cells (iPSCs) has expanded research into neurodevelopment, disease modeling, and drug testing. More recently, the concept organoid intelligence (OI) emerged, proposing that these constructs could evolve to support learning, memory, or even sentience. While this perspective driven enthusiasm in field suggested new applications fields such as neuromorphic computing, it also introduces significant scientific conceptual concerns. Current lack anatomical complexity, network organization, sensorimotor integration necessary for Despite this, claims surrounding OI often rely on oversimplified interpretations neural activity, fueled by neurorealist reification biases misattribute neurophysiological properties biologically limited systems. Beyond limitations, framing risks imposing ethical regulatory challenges based speculative concerns rather than empirical evidence. assumption might possess sentience, develop over time, lead unnecessary restrictions legitimate while misrepresenting their actual capabilities. Additionally, comparing biological systems silicon-based computing overlooks fundamental differences scalability, efficiency, predictability, raising questions about whether can meaningfully contribute computational advancements. must recognize limitations models prematurely defining a distinct domain. A more cautious, evidence-driven approach is ensure remain valuable tools neuroscience without overstating potential. To maintain credibility public trust, essential separate narratives grounded research, thus allowing continued progress studies reinforcing misconceptions

Language: Английский

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