Mitochondrial transplantation via injection of exogenous mitochondria into blood reduces bleomycin-induced oxidative damages and mitochondrial dysfunction in lung tissue

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)

Published: March 10, 2025

Language: Английский

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Exploring the mitigating potential of anthocyanin Malvidin in a mouse model of bleomycin-induced pulmonary fibrosis by inhibiting NLRP3 inflammasome activation and oxidative stress

Journal of Inflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: March 31, 2025

Malvidin (MV), an essential anthocyanin, has antioxidant and anti-inflammatory effects that may help treat pulmonary fibrosis (PF), a progressive occasionally fatal condition characterized by severe lung scarring, oxidative stress, inflammation. This study aims to evaluate the therapeutic potential of MV in PF assessing its on inflammation, fibrotic markers through vitro vivo models. The compound was evaluated molecular docking. BEAS-2B RLE-6TN cells were treated with 200 µg/mL BLM induce followed treatment. Cell viability, ROS levels, wound healing analyzed. In vivo, BLM-induced mice assess biomarkers. interacted NLRP3 binding energy -7 kcal/mol. increased cell viability cells, reducing stress. Wound enhanced MV-treated groups. A decrease HYP proteins confirms MV's antifibrotic effects. model, reduced TXNIP, MDA, MPO while increasing CAT, GSH, SOD, confirming capacity. alleviated model via inflammasome pathway, demonstrating as agent.

Language: Английский

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Carvacrol protects rats against bleomycin-induced lung oxidative stress, inflammation, and fibrosis

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(12), P. 10075 - 10089

Published: July 8, 2024

Language: Английский

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Diacerein ameliorates amiodarone-induced pulmonary fibrosis via targeting the TGFβ1/α-SMA/Smad3 pathway

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Abstract This study is aimed at investigating the possible protective effect of diacerein (DIA) against AMD-induced pulmonary fibrosis in rats. Rats were classified into 4 groups: a normal group that received distilled water, control AMD (100 mg/kg, p.o.) for 21 days to induce fibrosis, and 2 treatment groups diacerein, dose levels (50 100 p.o., respectively) addition p.o.), days. Lung function test was assessed using spirometer; serum tissue collected. Biochemical, real-time PCR, histopathological, immunohistopathological analyses carried out. reduced tidal volume (TV), peripheral expiratory rate (PER), forced vital capacity (FVC), glutathione (GSH) levels, Beclin, LCII, while it elevated transform growth factor (TGF-β1) gene expression, malondialdehyde (MDA) level, alpha-smooth muscle actin (α-SMA), Smad3, phosphorylated signal transducer activator transcription (p-STAT3), p62 lung content. Also, tumor necrosis factor-alpha (TNF-α) caspase-3 protein expression. DIA TV, PER, FVC, GSH TGF-β1 MDA α-SMA, p-STAT-3, Moreover, TNF-α attenuated via alleviating TGF1/α-SMA/Smad3 pathway, reducing STAT-3 activation, combating oxidative stress inflammation promoting autophagy abrogating apoptosis.

Language: Английский

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Protective effect of Essential oil of Foeniculum vulgare Mill. against bleomycin-induced pulmonary fibrosis and oxidative stress in rat

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(4), P. 100660 - 100660

Published: Oct. 18, 2024

Language: Английский

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