Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis DOI Creative Commons
Hui Zhao, Tian Liu, Chang-E Yang

et al.

Brazilian Journal of Medical and Biological Research, Journal Year: 2024, Volume and Issue: 57

Published: Jan. 1, 2024

Renal fibrosis is a common manifestation in the progression of chronic kidney disease (CKD) to failure. Currently, there no available therapy prevent renal fibrosis. Poricoic acid A (PAA) isolated from Poria cocos shows notable antifibrotic effects. However, its potential mechanism still unclear. This study aimed evaluate effects and mechanisms PAA against mouse model was established using unilateral ureteral obstruction (UUO). We showed that administration significantly alleviated lesions collagen deposition UUO mice. Mice with resulted epithelial-to-mesenchymal transition (EMT) activation endoplasmic reticulum stress (ERS) tissues, while treatment inhibited EMT ERS activation. Additionally, markedly ERS-mediated apoptosis Molecular docking results indicated stably combined GRP78 ATF4. In conclusion, these demonstrated possesses significant bioactivity might be inhibition apoptosis.

Language: Английский

Poricoic acid A attenuates renal fibrosis by inhibiting endoplasmic reticulum stress-mediated apoptosis DOI Creative Commons
Hui Zhao, Tian Liu, Chang-E Yang

et al.

Brazilian Journal of Medical and Biological Research, Journal Year: 2024, Volume and Issue: 57

Published: Jan. 1, 2024

Renal fibrosis is a common manifestation in the progression of chronic kidney disease (CKD) to failure. Currently, there no available therapy prevent renal fibrosis. Poricoic acid A (PAA) isolated from Poria cocos shows notable antifibrotic effects. However, its potential mechanism still unclear. This study aimed evaluate effects and mechanisms PAA against mouse model was established using unilateral ureteral obstruction (UUO). We showed that administration significantly alleviated lesions collagen deposition UUO mice. Mice with resulted epithelial-to-mesenchymal transition (EMT) activation endoplasmic reticulum stress (ERS) tissues, while treatment inhibited EMT ERS activation. Additionally, markedly ERS-mediated apoptosis Molecular docking results indicated stably combined GRP78 ATF4. In conclusion, these demonstrated possesses significant bioactivity might be inhibition apoptosis.

Language: Английский

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