Experimental study of cBMMSC based on nanosilver hydrogel nerve conduit for repairing spinal cord injury DOI Creative Commons
Zhu-Xiao Tang,

Yahui Ye,

Kaichuang Yang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(22)

Published: Nov. 1, 2024

Abstract Investigating the role of cranial bone marrow mesenchymal stem cells (cBMMSC) based on nanosilver hydrogel nerve conduits in repair spinal cord injury. Thirty adult Wistar rats, male and female, with body mass 210‐240 g, were selected as experimental animals divided into control group group, 15 rats each, by random number table method. The was treated injury localized transplantation cBMMSC‐containing conduits, while cBMMSC‐free conduits. Four weeks after transplantation, expression neuron‐specific enolase (NSE) rat anti‐human nuclear monoclonal antibody (MAB1281)‐positive detected immunostaining tissue sections two groups to assess differentiation cBMMSC neuron‐like transplantation; BrdU‐positive neuronal regeneration groups; length axons observed laser Confocal photography used observe axons; HE staining scarring cavities immunofluorescence detect markers (Nestin, NSE, NF200, GFAP) groups, OD values determined Image Processing Analysis System (IPAAS); Western blot neurotransmitters motor fibres, acetylcholinesterase (ChAT), sensory well neurotransmission acetylcholine production‐limiting enzyme (ChAT) fibre neurotransmitter glutamate synthase (GOGAT); function assessed BBB score; somatosensory evoked potentials (SEPs) (MEPs) surface electrode assay neurophysiological recovery effect evaluated. NSE content MAB1281‐positive significantly higher than that group; axon greater ( p < 0.05); cavitation slices lighter levels Nestin, GFAP, ChAT, GOGAT, scores SEP MEP latency time shorter 0.05), wave amplitude 0.05). conduit effective repairing injury, promoting axonal regeneration, restoring neuromotor electrophysiological functions.

Language: Английский

Global research trends and emerging hotspots in nano-drug delivery systems for lung cancer: a comprehensive bibliometric analysis (1998–2024) DOI Creative Commons
Yu Cao, Chunhai Fan, Y. Chen

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 11, 2025

Nano-drug delivery systems (NDDS) have become a promising alternative and adjunctive strategy for lung cancer (LC) treatment. However, comprehensive bibliometric analyses examining global research efforts on NDDS in LC are scarce. This study aims to fill this gap by identifying key trends, emerging hotspots, collaboration networks within the field of LC. A total 2452 publications, spanning from 1998 2024, were extracted Web Science Core Collection. The data analyzed using tools such as VOSviewer, CiteSpace, R package 'bibliometrix'. analysis covered contributions 12,539 researchers affiliated with 2689 institutions across 55 countries, their work published 551 different journals. Research output has increased steadily, China United States leading both publication volume impact. Major contributors include Chinese Academy Sciences Shanghai Jiao Tong University. International Journal Nanomedicine most articles, while Controlled Release ranked highest co-citations. Kamal Dua authored papers, Maeda, H. was frequently co-cited author. Key areas encompass "active targeting", "drug optimization", "overcoming drug resistance", "nanocarriers", "pulmonary delivery". Emerging hotspots "epithelial mesenchymal transition", "mucus penetration", "lipid nanoparticles", "hydrogels", "immune checkpoint inhibitors". analysis, first LC, identifies targeting" nanoparticles" These findings provide essential insights guide future optimize treatment strategies.

Language: Английский

Citations

1
Conditioned medium derived from mesenchymal stem cells and spinal cord injury: a review of the current therapeutic capacities DOI Creative Commons
Gholam Reza Kaka,

Farrokh Modarresi

IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: 18, P. 293 - 299

Published: Feb. 6, 2025

Spinal cord injury (SCI) is a debilitating condition of the nervous system that imposes considerable challenges for subjects, such as bladder and bowel incontinence infections. The standard therapeutic strategy methylprednisolone utilization accompanied by surgical decompression. However, achieving an effective therapy with minimum side effects SCI still puzzle. Nowadays, mesenchymal stem cell (MSC) has received much consideration in scientific communities light its pharmacological properties, instance, anti-inflammatory, regenerative, analgesic, immunomodulatory influences. Despite mentioned advantages MSCs, their tumorigenic potential limiting agent wide application. Recent documents show use conditioned medium (CM) derived from MSCs can largely solve these problems. CM encompasses neuroprotective growth factors cytokines, factor (SCF), vascular endothelial (VEGF), glial line-derived neurotrophic (GDNF). persuasive evidence experimental studies revealed originating have role amelioration SCI. Hence, current papers, we will review summarize indicating anti-SCI mechanisms MSC-derived relying data.

Language: Английский

Citations

0
Acetylsalicylic acid and cancer: updates on the new potential of a nature-inspired drug DOI
Abdur Rauf, Ahmed Olatunde, Rezaul Islam

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Harnessing the therapeutic potential of mesenchymal stem cells in cancer treatment DOI Creative Commons
Parisa Kangari,

Reza Salahlou,

Somayeh Vandghanooni

et al.

Advanced Pharmaceutical Bulletin, Journal Year: 2024, Volume and Issue: 14(3), P. 574 - 590

Published: June 22, 2024

Cancer, as a complicated disease, is considered to be one of the major leading causes death globally. Although various cancer therapeutic strategies have been established, however, some issues confine efficacies treatments. In recent decades researchers for finding efficient solutions extensively focused on abilities stem cells in inhibition. Mesenchymal (MSCs) are multipotent stromal that can most widely extracted from sources such bone marrow (BM), placenta, umbilical cord (UC), menses blood, Wharton's jelly (WJ), adipose tissue and dental pulp (DP). These capable differentiating into osteoblasts, chondrocytes, adipocytes. Due unique characteristics MSCs paracrine effects, immunomodulation, tumor-tropism, migration, they promising candidates therapeutics. Currently, an excellent living carrier delivery genes chemical agents target tumor sites. Also, exosomes, important extracellular vesicle released MSCs, act strong cell-free tool prevent progression by inhibiting several signaling pathways, wnt/β-catenin PI3K/AKT/mTOR. However, there challenges associated with use their exosomes field therapy need considered. This review explores significance cell-based therapy, focusing homing properties immunomodulatory characteristics. It also examines potential using carriers anticancer role modulating signal transduction pathways cells.

Language: Английский

Citations

1
Umbilical cord mesenchymal stem cells: a powerful fighter against colon cancer? DOI
Leila Kalantari, Ashkan Hajjafari, Pouya Goleij

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 90, P. 102523 - 102523

Published: Aug. 14, 2024

Language: Английский

Citations

1
Experimental study of cBMMSC based on nanosilver hydrogel nerve conduit for repairing spinal cord injury DOI Creative Commons
Zhu-Xiao Tang,

Yahui Ye,

Kaichuang Yang

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(22)

Published: Nov. 1, 2024

Abstract Investigating the role of cranial bone marrow mesenchymal stem cells (cBMMSC) based on nanosilver hydrogel nerve conduits in repair spinal cord injury. Thirty adult Wistar rats, male and female, with body mass 210‐240 g, were selected as experimental animals divided into control group group, 15 rats each, by random number table method. The was treated injury localized transplantation cBMMSC‐containing conduits, while cBMMSC‐free conduits. Four weeks after transplantation, expression neuron‐specific enolase (NSE) rat anti‐human nuclear monoclonal antibody (MAB1281)‐positive detected immunostaining tissue sections two groups to assess differentiation cBMMSC neuron‐like transplantation; BrdU‐positive neuronal regeneration groups; length axons observed laser Confocal photography used observe axons; HE staining scarring cavities immunofluorescence detect markers (Nestin, NSE, NF200, GFAP) groups, OD values determined Image Processing Analysis System (IPAAS); Western blot neurotransmitters motor fibres, acetylcholinesterase (ChAT), sensory well neurotransmission acetylcholine production‐limiting enzyme (ChAT) fibre neurotransmitter glutamate synthase (GOGAT); function assessed BBB score; somatosensory evoked potentials (SEPs) (MEPs) surface electrode assay neurophysiological recovery effect evaluated. NSE content MAB1281‐positive significantly higher than that group; axon greater ( p < 0.05); cavitation slices lighter levels Nestin, GFAP, ChAT, GOGAT, scores SEP MEP latency time shorter 0.05), wave amplitude 0.05). conduit effective repairing injury, promoting axonal regeneration, restoring neuromotor electrophysiological functions.

Language: Английский

Citations

1