Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies DOI Creative Commons
Ademola C. Famurewa, Roland Eghoghosoa Akhigbe,

Mina Y. George

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Language: Английский

Advances in Ferroptosis and Glucocorticoid-Induced Osteonecrosis of Femoral Head and Discussion of Related Ferroptosis Genes in Bone Metabolism or Oxidative Stress DOI

绍庚 王

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(01), P. 1717 - 1730

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the Molecular Interactions Between Ferroptosis and the Wnt/β-Catenin Signaling Pathway: Implications for Cancer and Disease Therapy DOI
Hui Jia,

Che Bian,

Yi Chang

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104674 - 104674

Published: Feb. 1, 2025

Language: Английский

Citations

0
The metabolites of gut microbiota: their role in ferroptosis in inflammatory bowel disease DOI Creative Commons
Jingying Zhou,

Peicheng Lu,

Haolong He

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 7, 2025

Inflammatory bowel disease (IBD) includes chronic inflammatory conditions, such as Crohn's and ulcerative colitis, characterized by impaired function of the intestinal mucosal epithelial barrier. In recent years, ferroptosis, a novel form cell death, has been confirmed to be involved in pathological process IBD is related various changes, oxidative stress inflammation. Recent studies have further revealed complex interactions between microbiome indicating that ferroptosis an important target for regulation gut microbiota its metabolites. This article reviews significant roles microbial metabolites, short-chain fatty acids, tryptophan, bile IBD. These metabolites participate influencing microenvironment, modulating immune responses, altering levels, thereby exerting impact on development Treatments based are gradually becoming research hotspot. Finally, we discuss potential current therapeutic approaches, including antibiotics, probiotics, prebiotics, fecal transplantation, microbiota, affecting improving symptoms. With deeper understanding interaction mechanisms it expected more precise effective treatment strategies will developed future.

Language: Английский

Citations

0
Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies DOI Creative Commons
Ademola C. Famurewa, Roland Eghoghosoa Akhigbe,

Mina Y. George

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Abstract Chemotherapy (CT) is one of the flagship options for treatment cancers worldwide. It involves use cytotoxic anticancer agents to kill or inhibit proliferation cancer cells. However, despite its clinical efficacy, CT triggers side effect toxicities in several organs, which may impact patient’s quality life and outcomes. While toxicity consistent with non-ferroptotic mechanisms involving oxidative stress, inflammation, mitochondrial impairment other aberrant signalling leading apoptosis necroptosis, recent studies show that ferroptosis, a non-apoptotic, iron-dependent cell death pathway, also involved pathophysiology organ toxicity. provokes ferroptosis via system Xc – /GPX-4/GSH/SLC7A11 axis depletion, ferritinophagy, iron overload, lipid peroxidation upregulation ferritin-related proteins. Cisplatin (CP) doxorubicin (DOX) are common drugs indicated induce vitro vivo. Studies have explored natural preventive therapeutic strategies using ginger rhizome major bioactive compounds, 6-gingerol (6G) zingerone (ZG), combat Ginger extract, 6G ZG mitigate dysfunction toxicity, but their effects on CT-induced remain unclear. Systematic investigations are, therefore, needed unfold roles ginger, as they potential prevention This review reveals ferroptotic protective against CT-induced, toxicities.

Language: Английский

Citations

0