Arginine Maillard Reaction Products Recovered Damaged Immune Cells DOI Creative Commons

Yanan Ding,

Pingfan Rao,

Jianwu Zhou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Instant noodle has been an initiating point for food industry in many countries, and it continues to be a beloved convenient the world. However, some products cause discomfort after consumption despite full compliance both ingredients processing methods. It not only resulted serious consumer misunderstanding but also affect as well. A simple solution possibly lies nowhere its soup which uses Maillard reaction flavoring agents. Arginine-glucose MRPs (Arg-Glc MRPs) have demonstrated antioxidant anti-inflammatory, can useful remove caused discomfort. Here we show that Arg-Glc neither produced significant cytotoxicity nor oxidative stress RAW264.7 macrophages. In APPH-induced damage model they remarkably reduced cytoplasmic ROS O2·−, restored polarization of membrane potential mitochondrial while enhancing phagocytic function normal cells oxidatively damaged cells. Those vitro results indicate usage promising problems.

Language: Английский

Apigenin improves chronic gastric ulcer in rats: the implication of COX-1/2 and 5-LOX signaling pathways DOI
Islam Omar Abdel Fattah, Wael Amin Nasr El‐Din

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102838 - 102838

Published: March 6, 2025

Language: Английский

Citations

0
Bio‐Inspired, Zwitterionic Copolymers with Amphiphilic Character DOI Creative Commons
Theresa Lutz,

Cevin Braksch,

Jonas De Breuck

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Abstract Selectively targeting diseases with therapeutics remains a crucial yet still unsatisfied challenge in (nano)medicine. In recent years, large body of biologically based drug carrier systems are produced which have proven to be suitable for the efficient transport active compounds such as biopharmaceuticals and biotechnological drugs. However, those naturally occurring materials often entail risks, example, due accessible, functional groups created by uncontrolled protein denaturation processes enzymes (e.g., proteases) can lead unwanted side effects body. To deal this issue, designing bio‐inspired synthetic copolymers offers alternative compared on derived from natural sources. Owing variety electrostatically interacting motifs abundant nature, statistical developed different polarity zwitterionic arginine‐derived units. achieve required physicochemical demands, simple one‐step synthesis approach is applied, so‐called xanthate‐supported photo‐iniferter reversible‐addition‐fragmentation chain‐transfer (XPI‐RAFT) polymerization. The cellular association these polymers fully non‐ionic polymer. results highlight new findings design macromolecule structures medical applications further progress understanding driving forces cell specificity polyzwitterions.

Language: Английский

Citations

0
Arginine Maillard Reaction Products Recovered Damaged Immune Cells DOI Creative Commons

Yanan Ding,

Pingfan Rao,

Jianwu Zhou

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Instant noodle has been an initiating point for food industry in many countries, and it continues to be a beloved convenient the world. However, some products cause discomfort after consumption despite full compliance both ingredients processing methods. It not only resulted serious consumer misunderstanding but also affect as well. A simple solution possibly lies nowhere its soup which uses Maillard reaction flavoring agents. Arginine-glucose MRPs (Arg-Glc MRPs) have demonstrated antioxidant anti-inflammatory, can useful remove caused discomfort. Here we show that Arg-Glc neither produced significant cytotoxicity nor oxidative stress RAW264.7 macrophages. In APPH-induced damage model they remarkably reduced cytoplasmic ROS O2·−, restored polarization of membrane potential mitochondrial while enhancing phagocytic function normal cells oxidatively damaged cells. Those vitro results indicate usage promising problems.

Language: Английский

Citations

0