Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride‐induced neurotoxicity in rats DOI Creative Commons
Ademola Adetokunbo Oyagbemi, Omowumi Femi‐Akinlosotu, Adedunsola Adewunmi Obasa

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)

Published: May 1, 2025

Abstract INTRODUCTION Aluminum chloride (AlCl 3 ) exposure has been linked to neurotoxicity in various animal models, presenting significant concern human health due its potential implications neurodegenerative diseases. is a widely recognized neurotoxin and used as an model of Alzheimer's disease via mechanisms with oxidative stress inflammation. The study investigated the ameliorative effect apigenin on AlCl ‐induced rats. METHODS Forty adult male Wistar rats were randomly divided into four different groups – control, (100 mg/kg), (50 mg/kg) plus , alone administered orally for 14 days. RESULTS Our findings revealed induced neurobehavioral deficits, stress, neuroinflammation, loss Purkinje cell layer cerebellum. Treatment attenuated neuroinflammation enhanced learning memory improvement recognition index. DISCUSSION Apigenin demonstrates promising effects against Highlights toxicity caused reduction learning, exploration, memory. neurotoxicity, increased biomarkers precipitated cognitive impairment. improved brain antioxidant,

Language: Английский

Protection of Lutein Against the Toxic Effect of Cisplatin on Liver in Male Rat DOI
İbrahim Aktaş, Fatih Mehmet Gür, Sedat Bilğiç

et al.

Prostaglandins & Other Lipid Mediators, Journal Year: 2025, Volume and Issue: 178, P. 106995 - 106995

Published: April 25, 2025

Language: Английский

Citations

0
Apigenin mitigates oxidative stress, neuroinflammation, and cognitive impairment but enhances learning and memory in aluminum chloride‐induced neurotoxicity in rats DOI Creative Commons
Ademola Adetokunbo Oyagbemi, Omowumi Femi‐Akinlosotu, Adedunsola Adewunmi Obasa

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(5)

Published: May 1, 2025

Abstract INTRODUCTION Aluminum chloride (AlCl 3 ) exposure has been linked to neurotoxicity in various animal models, presenting significant concern human health due its potential implications neurodegenerative diseases. is a widely recognized neurotoxin and used as an model of Alzheimer's disease via mechanisms with oxidative stress inflammation. The study investigated the ameliorative effect apigenin on AlCl ‐induced rats. METHODS Forty adult male Wistar rats were randomly divided into four different groups – control, (100 mg/kg), (50 mg/kg) plus , alone administered orally for 14 days. RESULTS Our findings revealed induced neurobehavioral deficits, stress, neuroinflammation, loss Purkinje cell layer cerebellum. Treatment attenuated neuroinflammation enhanced learning memory improvement recognition index. DISCUSSION Apigenin demonstrates promising effects against Highlights toxicity caused reduction learning, exploration, memory. neurotoxicity, increased biomarkers precipitated cognitive impairment. improved brain antioxidant,

Language: Английский

Citations

0