Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014 DOI Creative Commons
Fan Wang, Xiangyang Wang, Chaowei Wang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 14, 2025

Introduction The hemoglobin-to-red blood cell distribution width ratio (HRR) is acknowledged as a promising new prognostic biomarker. Nevertheless, investigations into its connection with cognitive function have yielded unclear results. Aim This study aimed to investigate the association between and in older adults United States. Methods utilized data obtained from NHANES database, encompassing years 2011 2014. participant cohort consisted of elderly individuals aged 60 older, all whom underwent thorough assessments function, hemoglobin levels, red width. We employed weighted logistic regression analysis, along restricted cubic spline (RCS) curves subgroup analyses, rigorously evaluate function. Results encompassed total 2,520 participants, mean age 69.44 ± 6.76 years. After adjusting for multiple covariates, analysis indicated significant linear impairment HRR Specifically, each one-unit increase was associated an 82% reduction probability among participants (OR = 0.18, 95% CI: 0.04–0.78). relationship remained exist after categorized tertiles. Participants highest tertile exhibited 42% lower likelihood compared those lowest 0.58; 0.37–0.91, p 0.022). To validate robustness our findings, we conducted which consistently demonstrated stable results across evaluated groups. Conclusion cross-sectional revealed negative correlation

Language: Английский

Association between hemoglobin-to-red blood cell distribution width ratio and cognitive function in older US adults: a cross-sectional study based on the NHANES 2011–2014 DOI Creative Commons
Fan Wang, Xiangyang Wang, Chaowei Wang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 14, 2025

Introduction The hemoglobin-to-red blood cell distribution width ratio (HRR) is acknowledged as a promising new prognostic biomarker. Nevertheless, investigations into its connection with cognitive function have yielded unclear results. Aim This study aimed to investigate the association between and in older adults United States. Methods utilized data obtained from NHANES database, encompassing years 2011 2014. participant cohort consisted of elderly individuals aged 60 older, all whom underwent thorough assessments function, hemoglobin levels, red width. We employed weighted logistic regression analysis, along restricted cubic spline (RCS) curves subgroup analyses, rigorously evaluate function. Results encompassed total 2,520 participants, mean age 69.44 ± 6.76 years. After adjusting for multiple covariates, analysis indicated significant linear impairment HRR Specifically, each one-unit increase was associated an 82% reduction probability among participants (OR = 0.18, 95% CI: 0.04–0.78). relationship remained exist after categorized tertiles. Participants highest tertile exhibited 42% lower likelihood compared those lowest 0.58; 0.37–0.91, p 0.022). To validate robustness our findings, we conducted which consistently demonstrated stable results across evaluated groups. Conclusion cross-sectional revealed negative correlation

Language: Английский

Citations

0