Ultraviolet radiation oxidative stress affects eye health

Journal of Biophotonics, Journal Year: 2018, Volume and Issue: 11(7)

Published: March 31, 2018

In the eye, ultraviolet radiation (UVR) is not known to contribute visual perception but mainly damage multiple structures. UVR carries higher energy than visible light and high dose exposure causes direct cellular damage, which has an important role in development of cancer. This review provides overview on most recent knowledge oxidative stress (OS) relation noncancer ocular pathologies: various corneal pathologies, cataract, glaucoma age‐related macular degeneration. Possible OS signaling streams mechanisms aging eye are discussed. Excessive through live may seriously increase tissues thus lead advancement serious pathologies. Children especially vulnerable because their larger pupils more transparent media: up 80% a person's lifetime reached before age 18. Therefore, efficient everyday protection sensitive by wearing sunglasses, clear UVR‐blocking spectacles or contact lenses should be considered from early on. Many initiatives taken worldwide inform raise population's awareness about these possible hazards eye.

Language: Английский

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The inner clock—Blue light sets the human rhythm

Journal of Biophotonics, Journal Year: 2019, Volume and Issue: 12(12)

Published: Aug. 21, 2019

Visible light synchronizes the human biological clock in suprachiasmatic nuclei of hypothalamus to solar 24-hour cycle. Short wavelengths, perceived as blue color, are strongest synchronizing agent for circadian system that keeps most and psychological rhythms internally synchronized. Circadian rhythm is important optimum function organisms sleep-wake disruptions or chronic misalignment often may lead psychiatric neurodegenerative illness. The beneficial effect on synchronization, sleep quality, mood, cognitive performance depends not only spectral composition but also timing exposure its intensity. Exposure during day suppress melatonin secretion, hormone produced by pineal gland plays crucial role entrainment. While keeping organism's wellbeing, alertness, day, low-intensity directly before bedtime, have serious implications phase cycle durations. This rises inevitably need solutions improve today's modern society where emitting devices ever increasing.

Language: Английский

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Circadian regulation of depression: A role for serotonin

Frontiers in Neuroendocrinology, Journal Year: 2019, Volume and Issue: 54, P. 100746 - 100746

Published: April 16, 2019

Language: Английский

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Association Between Cataract Extraction and Development of Dementia

JAMA Internal Medicine, Journal Year: 2021, Volume and Issue: 182(2), P. 134 - 134

Published: Dec. 6, 2021

Visual function is important for older adults. Interventions to preserve vision, such as cataract extraction, may modify dementia risk.To determine whether extraction associated with reduced risk of among adults.This prospective, longitudinal cohort study analyzed data from the Adult Changes in Thought study, an ongoing, population-based randomly selected, cognitively normal members Kaiser Permanente Washington. Study participants were 65 years age or and free at enrollment followed up biennially until incident (all-cause, Alzheimer disease, disease related dementia). Only who had a diagnosis glaucoma before during follow-up included analyses (ie, total 3038 participants). Data used collected 1994 through September 30, 2018, all April 6, 2019, 15, 2021.The primary exposure interest was extraction. on surgery extracted electronic medical records. Extensive lists dementia-related factors health-related variables obtained visit records.The outcome defined by Diagnostic Statistical Manual Mental Disorders (Fourth Edition) criteria. Multivariate Cox proportional hazards regression conducted outcome. To address potential healthy patient bias, weighted marginal structural models incorporating probability association surgery, which does not restore evaluated.In total, (mean [SD] first diagnosis, 74.4 (6.2) years; 1800 women (59%) 1238 men (41%); 2752 (91%) self-reported White race). Based 23 554 person-years follow-up, significantly (hazard ratio, 0.71; 95% CI, 0.62-0.83; P < .001) compared without after controlling education, race, smoking history stratifying apolipoprotein E genotype, sex, group diagnosis. Similar results adjusting extensive list confounders. Glaucoma did have significant 1.08; 0.75-1.56; = .68). found development dementia.This that lower development. If validated future studies, clinical relevance adults developing dementia.

Language: Английский

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The cognitive impact of light: illuminating ipRGC circuit mechanisms

Nature reviews. Neuroscience, Journal Year: 2024, Volume and Issue: 25(3), P. 159 - 175

Published: Jan. 26, 2024

Language: Английский

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Spectral quality of light modulates emotional brain responses in humans

Proceedings of the National Academy of Sciences, Journal Year: 2010, Volume and Issue: 107(45), P. 19549 - 19554

Published: Oct. 25, 2010

Light therapy can be an effective treatment for mood disorders, suggesting that light is able to affect state in the long term. As a first step understand this effect, we hypothesized might also acutely influence emotion and tested whether short exposures modulate emotional brain responses. During functional magnetic resonance imaging, 17 healthy volunteers listened neutral vocal stimuli while being exposed alternating 40-s periods of blue or green ambient light. Blue (relative green) increased responses voice area temporal cortex hippocampus. processing, connectivity between area, amygdala, hypothalamus was selectively enhanced context illumination, which shows stimulation amygdala are influenced by both decoding information spectral quality These results demonstrate acute its on processing identify unique network merging affective information.

Language: Английский

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The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans

Journal of Pineal Research, Journal Year: 2011, Volume and Issue: 53(1), P. 47 - 59

Published: Sept. 20, 2011

The effect of light on circadian rhythms and sleep is mediated by a multi-component photoreceptive system rods, cones melanopsin-expressing intrinsically photosensitive retinal ganglion cells. intensity spectral sensitivity characteristics this are to be fully determined. Whether the composition exposure at home in evening such that it delays also remains established. We monitored during 6-8wk assessed effects laboratory. Twenty-two women men (23.1±4.7yr) participated six-way, cross-over design using polychromatic conditions relevant home, but with reduced, intermediate or enhanced efficacy respect photopic melanopsin systems. rise melatonin, sleepiness EEG-assessed onset varied significantly (P<0.01) across conditions, these appeared largely melanopsin, rather than system. Moreover, there were individual differences disruptive which robust against experimental manipulations (intra-class correlation=0.44). data show affects physiology imply artificial can modified minimize rhythms. These findings have implications for our understanding contribution rhythm disorders as delayed phase disorder.

Language: Английский

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Salutogenic Effects of the Environment: Review of Health Protective Effects of Nature and Daylight

Applied Psychology Health and Well-Being, Journal Year: 2013, Volume and Issue: 6(1), P. 67 - 95

Published: Nov. 21, 2013

Both nature and daylight have been found to positively influence health. These findings were, however, in two separate research domains. This paper presents an overview of effects for on health the health‐related concepts stress, mood, executive functioning self‐regulation. Because overlap co‐occurrence both phenomena, points need consider factors when investigating vice versa. Furthermore, existence possibly shared underlying mechanisms is discussed unify paradigms dependent variables used between fields. Last, view beneficial phenomena health, our objective raise awareness amongst general public, designers, practitioners use these naturally available their full potential.

Language: Английский

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Melanopsin Regulates Both Sleep-Promoting and Arousal-Promoting Responses to Light

PLoS Biology, Journal Year: 2016, Volume and Issue: 14(6), P. e1002482 - e1002482

Published: June 8, 2016

Light plays a critical role in the regulation of numerous aspects physiology and behaviour, including entrainment circadian rhythms sleep. These responses involve melanopsin (OPN4)-expressing photosensitive retinal ganglion cells (pRGCs) addition to rods cones. Nocturnal light exposure rodents has been shown result rapid sleep induction, which key role. However, studies have also that can elevated corticosterone, response is not compatible with To investigate these contradictory findings dissect relative contribution pRGCs rods/cones, we assessed effects different wavelengths on behaviourally defined Here, show blue (470 nm) causes behavioural arousal, elevating corticosterone delaying onset. By contrast, green (530 produces induction. Compared wildtype mice, are altered melanopsin-deficient mice (Opn4-/-), resulting enhanced but delayed induction or white light. We go evokes higher Fos SCN compared sleep-promoting ventrolateral preoptic area (VLPO), whereas produced greater VLPO. Collectively, our data demonstrates nocturnal either an arousal- effect, melanopsin-mediated via neural pathways spectral sensitivities. raise important questions relating how artificial may alter behaviour both work domestic setting.

Language: Английский

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Can light make us bright? Effects of light on cognition and sleep

Progress in brain research, Journal Year: 2011, Volume and Issue: unknown, P. 119 - 133

Published: Jan. 1, 2011

Language: Английский

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