NeuroImage,
Journal Year:
2024,
Volume and Issue:
291, P. 120602 - 120602
Published: April 4, 2024
Working
memory
(WM)
describes
the
dynamic
process
of
maintenance
and
manipulation
information
over
a
certain
time
delay.
Neuronally,
WM
recruits
distributed
network
cortical
regions
like
visual
dorsolateral
prefrontal
cortex
as
well
subcortical
hippocampus.
How
input
dynamics
subsequent
neural
impact
remains
unclear
though.
To
answer
this
question,
we
combined
analysis
behavioral
capacity
with
measuring
through
task-related
power
spectrum
changes,
e.g.,
median
frequency
(MF)
in
functional
magnetic
resonance
imaging
(fMRI).
We
show
that
processing
dynamics,
task
structure's
specific
timescale,
leads
to
changes
unimodal
cortex's
corresponding
timescale
which
also
relates
working
capacity.
While
more
transmodal
hippocampus
its
balance
across
multiple
timescales
or
frequencies.
In
conclusion,
here
relevance
both
different
for
uni
-
subject's
performance.
Neuron,
Journal Year:
2021,
Volume and Issue:
109(21), P. 3500 - 3520.e13
Published: Sept. 17, 2021
Dopamine
is
required
for
working
memory,
but
how
it
modulates
the
large-scale
cortex
unknown.
Here,
we
report
that
dopamine
receptor
density
per
neuron,
measured
by
autoradiography,
displays
a
macroscopic
gradient
along
macaque
cortical
hierarchy.
This
incorporated
in
connectome-based
model
endowed
with
multiple
neuron
types.
The
captures
an
inverted
U-shaped
dependence
of
memory
on
and
spatial
patterns
persistent
activity
observed
over
90
experimental
studies.
Moreover,
show
crucial
filtering
out
irrelevant
stimuli
enhancing
inhibition
from
dendrite-targeting
interneurons.
Our
revealed
activity-silent
trace
can
be
realized
facilitation
inter-areal
connections
adjusting
induces
switch
this
internal
state
to
distributed
activity.
work
represents
cross-level
understanding
molecules
cell
types
recurrent
circuit
dynamics
underlying
core
cognitive
function
across
primate
cortex.
Journal of Cognitive Neuroscience,
Journal Year:
2022,
Volume and Issue:
35(1), P. 17 - 23
Published: Nov. 2, 2022
Abstract
Working
memory
is
where
thoughts
are
held
and
manipulated.
For
many
years,
the
dominant
model
was
that
working
relied
on
steady-state
neural
dynamics.
A
representation
activated
then
in
state.
However,
as
often
happens,
more
we
examine
(especially
with
new
technology),
complex
it
looks.
Recent
discoveries
show
involves
multiple
mechanisms,
including
discontinuous
bouts
of
spiking.
Memories
also
dynamic,
evolving
a
task-dependent
manner.
Cortical
rhythms
may
control
those
dynamics,
thereby
endowing
top–down
“executive”
over
our
thoughts.
Human Brain Mapping,
Journal Year:
2024,
Volume and Issue:
45(3)
Published: Feb. 15, 2024
Abstract
The
hippocampus
and
parahippocampal
gyrus
have
been
implicated
as
part
of
a
tinnitus
network
by
number
studies.
These
structures
are
usually
considered
in
the
context
“limbic
system,”
concept
typically
invoked
to
explain
emotional
response
tinnitus.
Despite
this
common
framing,
it
is
not
apparent
from
current
literature
that
necessarily
main
functional
role
these
persistent
Here,
we
highlight
different
encompasses
their
most
commonly
position
within
brain—that
is,
memory
system.
We
consider
an
auditory
object
held
memory,
which
may
be
made
associated
activity
gyrus.
Evidence
animal
human
studies
implicating
reviewed
used
anchor
for
hypothesis.
potential
hippocampus/parahippocampal
facilitate
maintenance
percept
via
communication
with
cortex,
rather
than
(or
addition
to)
mediating
responses
percept.
PLoS Biology,
Journal Year:
2021,
Volume and Issue:
19(10), P. e3001436 - e3001436
Published: Oct. 21, 2021
Persistently
active
neurons
during
mnemonic
periods
have
been
regarded
as
the
mechanism
underlying
working
memory
maintenance.
Alternatively,
neuronal
networks
could
instead
store
memories
in
fast
synaptic
changes,
thus
avoiding
biological
cost
of
maintaining
an
code
through
persistent
firing.
Such
"activity-silent"
codes
proposed
for
specific
conditions
which
are
maintained
a
nonprioritized
state,
unattended
but
still
relevant
short-term
memories.
A
hallmark
this
is
that
these
can
be
reactivated
from
silent,
traces.
Evidence
storage
has
come
human
electroencephalography
(EEG),
particular
emergence
decodability
(EEG
reactivations)
induced
by
visual
impulses
(termed
pinging)
otherwise
"silent"
periods.
Here,
we
reanalyze
EEG
data
such
pinging
studies.
We
find
originally
reported
absence
decoding
reflects
weak
statistical
power,
possible
based
on
more
powered
analyses
or
reanalysis
using
alpha
power
raw
voltage.
This
reveals
"reactivations"
occur
presence
electrically
active,
not
data.
crucial
change
evidence
provided
dataset
prompts
reinterpretation
mechanisms
reactivations.
provide
2
explanations
backed
computational
models,
and
discuss
relationship
with
TMS-induced
