Precise Timing Matters: Modulating Human Memory by Synchronizing Hippocampal Stimulation to Saccadic Event Related Potentials DOI Creative Commons
Chaim N. Katz, Kramay Patel, Andrea Gómez Palacio Schjetnan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 13, 2024

Abstract Episodic memory, the ability to record and relive experiences, is intricately connected visual exploration in most humans. This study explores possibility that eye movements create physiological states relevant for analogous those associated with hippocampal theta. Previous work has demonstrated saccadic movements, which occur roughly at theta frequency, elicit event-related potentials (ERPs). Building on Separate Phases of Encoding Retrieval (SPEAR) model, we asked if peaks troughs this ERP are differentially important memory formation. Specifically, applied saccade-contingent electrical stimulation estimated while individuals epilepsy visually explored natural scenes across 59 sessions. We subsequently assessed their recognition recall targets. Results indicate robust when precisely targets peak or trough, contrasting impairments observed random stimulation. Moreover, impairment prominent within 100 ms saccade initiation, a time reflects high medial temporal lobe inhibition. Our findings suggest hippocampus rapidly evolves through memory-relevant following each movement, also challenging assumption human mirror encoding retrieval phases rhythms studied rodents. The sheds light dynamic interplay between activity, formation, offering theoretical insights potential applications modulation neurological disorders. Significance Statement Why do eye-movements enhance formation? Here, causally tested initiate short-lived critical formation hippocampus, brain region known support memory. built system could apply key moments after test how timing influenced people’s form memories. found was particularly disruptive initiating an movement. By contrast, timed trough eye-movement responses. interpret evolution model relate rodent

Language: Английский

Clock Drawing Test Performance of Young Adults Based on a One-Shot Case Study DOI
Samantha L McDaniel,

Linda Shuster,

Mary Kennedy

et al.

Archives of Clinical Neuropsychology, Journal Year: 2023, Volume and Issue: 39(2), P. 175 - 185

Published: Aug. 10, 2023

The clock drawing test (CDT) is being used regularly by medical professionals in a variety of settings to aid assessing cognitive functioning adults all ages. As our technological environment has changed significantly, because the inception this measure, use and exposure analog have diminished. We investigated whether young adults, who grown up mainly digital world, can draw tell time on an clock.

Language: Английский

Citations

3
Mapping Sleep’s Oscillatory Events as a Biomarker of Alzheimer’s Disease DOI Open Access

Rachelle L. Pulver,

Eugene Kronberg,

Lindsey M. Medenblik

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 16, 2023

Memory-associated neural circuits produce oscillatory events within single-channel sleep electroencephalography (EEG), including theta bursts (TBs), spindles (SPs) and multiple subtypes of slow waves (SWs). Changes in the temporal "coupling" these are proposed to serve as a biomarker for early stages Alzheimer's disease (AD) pathogenesis.

Language: Английский

Citations

2
Cortico-ocular coupling in the service of episodic memory formation DOI Creative Commons
Tzvetan Popov, Tobias Staudigl

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 10, 2022

Abstract Encoding of visual information is a necessary requirement for most types episodic memories. In search neural signature memory formation, amplitude modulation activity has been repeatedly shown to correlate with and suggested be functionally involved in successful encoding. We here report complementary view on why how brain relates memory, indicating functional role cortico-ocular interactions formation. Recording simultaneous magnetoencephalography eye tracking 35 human participants, we demonstrate that gaze variability modulations alpha/beta oscillations (10-20 Hz) cortex covary predict subsequent performance between within participants. Amplitude variation during pre-stimulus baseline was associated direction variability, echoing the co-variation observed scene conclude encoding engages unison coupling oculomotor areas service

Language: Английский

Citations

4
Saccades are locked to the phase of alpha oscillations during natural reading DOI Creative Commons
Yali Pan, Tzvetan Popov, Steven Frisson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: April 10, 2022

Abstract We saccade three to five times per second when reading. However, little is known about the neuronal mechanisms coordinating oculomotor and visual system during such rapid processing. Here we ask if brain oscillations play a role in temporal coordination of visuomotor integration. simultaneously acquired MEG eye-tracking data while participants read sentences silently. Every sentence was embedded with target words either high or low lexical frequency. Our key finding demonstrated that onsets were locked phase alpha (8 – 13 Hz); particular, for saccades towards low-frequency words. Source modelling which locked, generated right-associative cortex (BA 19). findings suggest serve time processing between systems natural reading, this becomes more pronounced demanding Significance Statement Reading an essential skill modern society allows us acquire information from written language. While effortlessly can meaning text, task reading requires precisely timed as our eyes jump word word. By using task, demonstrate clocked by ongoing ~10 Hz cortex. The clocking became particularly made

Language: Английский

Citations

3
Precise Timing Matters: Modulating Human Memory by Synchronizing Hippocampal Stimulation to Saccadic Event Related Potentials DOI Creative Commons
Chaim N. Katz, Kramay Patel, Andrea Gómez Palacio Schjetnan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 13, 2024

Abstract Episodic memory, the ability to record and relive experiences, is intricately connected visual exploration in most humans. This study explores possibility that eye movements create physiological states relevant for analogous those associated with hippocampal theta. Previous work has demonstrated saccadic movements, which occur roughly at theta frequency, elicit event-related potentials (ERPs). Building on Separate Phases of Encoding Retrieval (SPEAR) model, we asked if peaks troughs this ERP are differentially important memory formation. Specifically, applied saccade-contingent electrical stimulation estimated while individuals epilepsy visually explored natural scenes across 59 sessions. We subsequently assessed their recognition recall targets. Results indicate robust when precisely targets peak or trough, contrasting impairments observed random stimulation. Moreover, impairment prominent within 100 ms saccade initiation, a time reflects high medial temporal lobe inhibition. Our findings suggest hippocampus rapidly evolves through memory-relevant following each movement, also challenging assumption human mirror encoding retrieval phases rhythms studied rodents. The sheds light dynamic interplay between activity, formation, offering theoretical insights potential applications modulation neurological disorders. Significance Statement Why do eye-movements enhance formation? Here, causally tested initiate short-lived critical formation hippocampus, brain region known support memory. built system could apply key moments after test how timing influenced people’s form memories. found was particularly disruptive initiating an movement. By contrast, timed trough eye-movement responses. interpret evolution model relate rodent

Language: Английский

Citations

0