Multiple routes to enhanced memory for emotionally relevant events

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(9), P. 867 - 882

Published: July 19, 2023

Language: Английский

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Declining locus coeruleus–dopaminergic and noradrenergic modulation of long-term memory in aging and Alzheimer’s disease

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 153, P. 105358 - 105358

Published: Aug. 17, 2023

Language: Английский

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Collective events and individual affect shape autobiographical memory

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(29)

Published: July 11, 2023

How do collective events shape how we remember our lives? We leveraged advances in natural language processing as well a rich, longitudinal assessment of 1,000 Americans throughout 2020 to examine memory is influenced by two prominent factors: surprise and emotion. Autobiographical for displayed unique signature: There was substantial bump March, aligning with pandemic onset lockdowns, consistent across three collections 1 y apart. further investigated emotion, using both immediate retrieved measures, predicted the amount content autobiographical memory: Negative affect increased recall all whereas its more clinical indices, depression posttraumatic stress disorder, selectively nonepisodic recall. Finally, separate cohort, found news be better remembered, surprising, negative, while lockdowns compressed remembered time. Our work connects laboratory findings real world delineates effects acute versus signatures negative emotion on memory.

Language: Английский

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Prediction error and event segmentation in episodic memory

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 157, P. 105533 - 105533

Published: Jan. 4, 2024

Language: Английский

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Integrating and fragmenting memories under stress and alcohol

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 30, P. 100615 - 100615

Published: Feb. 8, 2024

Stress can powerfully influence the way we form memories, particularly extent to which they are integrated or situated within an underlying spatiotemporal and broader knowledge architecture. These different representations in turn have significant consequences for use these memories guide later behavior. Puzzlingly, although stress has historically been argued promote fragmentation, leading disjoint memory representations, more recent work suggests that also facilitate binding integration. Understanding circumstances under fosters integration will be key resolving this discrepancy unpacking mechanisms by shape Here, examine at multiple levels: linking together content of individual experience, threading associations between related but distinct events, experience into a pre-existing schema sense causal structure. We discuss neural cognitive each as well findings regarding how stress, aversive learning, negative affect modulate each. In analysis, uncover indeed level show may apply understanding effects alcohol, highlighting extant clinical preclinical opportunities further investigation. Finally, consider implications fragmentation memory-guided behavior, importance type representation is potentiated order design appropriate interventions.

Language: Английский

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The reach of reactivation: Effects of consciously triggered versus unconsciously triggered reactivation of associative memory

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(10)

Published: Feb. 26, 2024

Consolidating memories for long-term storage depends on reactivation. Reactivation occurs both consciously, during wakefulness, and unconsciously, wakefulness sleep. While considerable work has examined conscious awake unconscious sleep reactivation, in this study, we directly compare the consequences of reactivation wakefulness. Forty-one participants learned associations consisting adjective-object-position triads. Objects were clustered into distinct semantic groups (e.g., fruits, vehicles) such that could examine semantically related memories. After an intensive learning protocol, systematically reactivated some triads by presenting adjective as a cue. was done so it consciously experienced triads, only unconsciously processed others. Memory spatial positions, most distal part association, affected consciousness-dependent memory-strength-dependent manner. Conscious resulted weakening strong initially, resonating with prior findings retrieval-induced forgetting. Unconscious other hand, selectively benefited weak memories, previously shown Semantically linked not impaired, but rather integrated memory. These results taken together demonstrate have qualitatively different consequences. Results support inhibition account, whereby entails less than thus allowing more liberal spread activation. Findings set stage additional exploration role experience memory structuring.

Language: Английский

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Pavlovian safety learning: An integrative theoretical review

Psychonomic Bulletin & Review, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Language: Английский

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Emotion in the mind's eye: Imagination for adaptive cognition

Annals of the New York Academy of Sciences, Journal Year: 2023, Volume and Issue: 1526(1), P. 59 - 72

Published: June 21, 2023

Abstract In a complex world, we are constantly faced with environmental stimuli that shape our moment‐to‐moment experiences. But just as rich and the external world is internal milieu—our imagination. Imagination offers powerful vehicle for playing out hypothetical experiences in mind's eye. It allows us to mentally time travel behold what future might bring, including greatest desires or fears. Indeed, imagined tend be emotion‐laden. How why humans capable of this remarkable feat? Based on psychological findings, highlight importance imagination emotional aspects cognition behavior, namely generation regulation emotions. recent cognitive neuroscience work, identify putative neural networks most critical imagination, major focus default mode network. Finally, briefly possible functional implications individual differences Overall, hope address have capacity simulate how ability can harnessed adaptive (and sometimes maladaptive) ways. We end by discussing open questions.

Language: Английский

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Making memories last using the peripheral effect of direct current stimulation

eLife, Journal Year: 2023, Volume and Issue: 12

Published: May 19, 2023

Most memories that are formed forgotten, while others retained longer and subject to memory stabilization. We show non-invasive transcutaneous electrical stimulation of the greater occipital nerve (NITESGON) using direct current during learning elicited a long-term effect. However, it did not trigger an immediate effect on learning. A neurobiological model proposes mechanism by which initially unstable can be strengthened through subsequent novel experiences. In series studies, we demonstrate NITESGON’s capability boost retention when applied shortly before, during, or after time enhancing consolidation via activation communication in between locus coeruleus pathway hippocampus plausibly modulating dopaminergic input. These findings may have significant impact for neurocognitive disorders inhibit such as Alzheimer’s disease.

Language: Английский

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Aerobic exercise after extinction learning reduces return of fear and enhances memory of items encoded during extinction learning

Mental health and physical activity, Journal Year: 2023, Volume and Issue: 24, P. 100510 - 100510

Published: Feb. 11, 2023

Language: Английский

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