Cited by Guideline for the clinical application of transcranial alternating current stimulation

Guideline for the clinical application of transcranial alternating current stimulation DOI

et al.

Chinese Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 14, 2025

Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation technique that regulates brain function by applying sinusoidal currents of specific frequencies to targeted regions through the scalp electrodes.[1] This guideline aims evaluate and summarize efficacy safety tACS in clinical applications. We conducted structured literature search across major databases using terms "tACS" or "transcranial stimulation" identify all relevant up June 2022. After rigorous screening, total 35 articles were included this (the detailed screening process illustrated Supplementary Figure 1, https://links.lww.com/CM9/C402). The uses Grades Recommendation, Assessment, Development, Evaluation (GRADE) evidence quality evaluation recommendation strength grading standards established World Health Organization (WHO) for these trials.[2] Following Delphi method, electronic questionnaires distributed multiple specialized groups. collection, summarization, feedback, application opinions grades various diseases finalized (detailed procedures are provided Material procedures: commonly used methods can be categorized into three types based on intensity: superhigh-energy (superhigh tACS, intensity >100 mA), high-energy (high >10–100 medium-energy (medium 4–10 mA) low-energy (low <4 mA).[3] Within certain range, higher intensities result broader range endogenous effects, stronger entrainment capabilities, deeper penetration.[4] In article, same phase electrodes "[]", whereas different electrodes/groups separated "-". If loops exist, they ";". frequency another critical parameter. Low (θ waves, 4–7 Hz) often promote relaxation improve sleep, (γ 30–100 may enhance cognitive functions alertness. Detailed protocols operational described 2, https://links.lww.com/CM9/C402. Clinical applications tACS:Insomnia disorder: modulate cortical excitability function, sleep efficiency quality, alleviate insomnia symptoms influencing synchronization desynchronization neuronal electrical activity brain. High-quality indicates 15 mA, 77.5 Hz with placed at [prefrontal lobe]-[bilateral mastoid] improves chronic patients. Low-quality suggests 0.75 [F3]-[left mastoid area]; [F4]-[right area] also patients information Table Recommendations: For patients, high region]-[bilateral strongly recommended quality. might useful improving Cognitive dysfunction Alzheimer's disease (AD): studies have primarily focused mild impairment (MCI) mild-to-moderate dementia. Some who diagnosed definitively AD pathologic examination. 2 40 over bilateral temporal enhances Moderate-quality 3 [Pz]-[right deltoid] episodic memory MCI low-quality did not find therapeutic effect detectable scales but reduce p-Tau burden. combined training longer duration than alone. sound weeks Fourteen home-based treatment AD-related dementia addition, appears offer superior benefits compared transcranial direct (tDCS) low region function. recommended. Chronic pain: 10 [F3, F4]-[Pz] alleviates back pain. 1–2 mA 4 30 (depending individual's dominant spectral power) [the highest power spectrum difference area]-[ipsilateral could pain fibromyalgia syndrome Low-level acute 0.4 140 [Oz]-[Cz] min effectively terminate migraine attacks 3, weakly symptoms. [Oz] – [Cz] Vestibular individual alpha [prefrontal]-[occipital] (2 [prefrontal, occipital]-[left upper arm] (4 20 per session 10–12 sessions oscillatory vertigo Mal de Débarquement Syndrome (MdDS) former configuration more effective, stimulating slightly preferable 4, MdDS vertigo. Stimulating preferable. Stroke rehabilitation: weeks, rehabilitation training, overall functional recovery subacute supratentorial intracerebral hemorrhage infarction 5, subacute-stage stroke recovery. Parkinson's disease: combining motor functions. Furthermore, [forehead]-[bilateral 45 has no significant effects mood 6, Epilepsy: most frequent interictal epileptiform discharge supraorbital region] 60 5 days fails seizure multifocal refractory epilepsy (including lobe epilepsy, frontal Lennox–Gastaut syndrome). Very 1 [Fp1]-[Fp2] daily increased 75% 16-year-old female myoclonic followed 15-day seizure-free period 7, No recommendations due insufficient evidence. Depressive disorders depressive states): from significantly shows F4]-[Cz] yields better antidepressant outcomes tACS. [F3]-[F4] twice reduces 8, depression, Combining antidepressants advised outcomes. Schizophrenia psychotic symptoms): between F3 Fp1, T3 P3]-[Cz] auditory hallucinations. Another moderate 6 [F1, F5, AF3, FC3]-[CPz]; [P1, P5, CP3, PO3]-[FCz] negative schizophrenia [AFz]-[Cz] severity delusions, [F3]-[P3] working 9, Substance addiction: habitual behaviors individuals substance addiction 10, https://links.lww.com/CM9/C402) Tolerability therapy: tolerability favorable. Common adverse reactions including photophobia (flash, phosphenes), itching, burning, tingling, fever, dizziness, headache, burning being frequently reported. 11, https://links.lww.com/CM9/C402 common observed during therapy provide management strategies. 12, outlines populations. continuous monitoring participants' responses administration advised, meticulous inspection electrode-skin interface should performed before after each session. Prospects tACS: With advancements neuroscience, future research expected establish disease-specific frequency-intensity-target models multimodal technologies develop personalized strategies neural oscillations genetic characteristics. widespread will ultimately depend evidence-based validation establishment standardized technical guidelines. Members Expert Steering Group( sorted last name) Dongmei An, Xuebing Cao, Haobo Chen, Ling Guiyun Cui, Jiahui Deng, Wei Jing Ding, Tao Feng, Zhengzhi Yuan Geng, Qiang Guan, Yi Guo, Yue Hou, Shaohua Hu, Yonghua Huang, Li Kuang, Tongliang Li, Zhe Zhanhua Liang, Jun Liu, Xuedong Yiming Xiaoyan Long, Jinghong Ma, Yan Mei, Xianghong Meng, Yijun Song, Chaoxia Su, Shujuan Tian, Yuling Zhirong Wan, Chunxue Wang, Jijun Kai Lin Mengyang Mingwei Qing Qun Xiaorong Yanyong Yuping Zan Shenhong Weng, Bingjie Wu, Jianjun Wenqing Yuncheng Anmu Xie, Fengquan Xu, Yuehong Zhi Liqing Yan, Xinling Yang, Qinyong Ye, Jie Yuan, Yonggui Lingyun Zeng, Linwei Zhang, Xiong Yang Yuhu Peng Zheng, Di Zhong, Bo Zhou, Hongcan Zhu. Acknowledgments authors acknowledge assistance Nan Hua Minyue Pei, Epidemiology Research Center, Peking University Third Hospital. Funding study was supported grants National Key Development Program China (Nos. 2021YFC2501400, 2021YFC2501404). Conflicts interest None.

Language: Английский

Intensity- and frequency-specific effects of transcranial alternating current stimulation are explained by network dynamics DOI

Zhihe Zhao, Sina Shirinpour, Harry Tran

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(2), P. 026024 - 026024

Published: March 26, 2024

Abstract Objective . Transcranial alternating current stimulation (tACS) can be used to non-invasively entrain neural activity and thereby cause changes in local oscillatory power. Despite its increased use cognitive clinical neuroscience, the fundamental mechanisms of tACS are still not fully understood. Approach We developed a computational neuronal network model two-compartment pyramidal neurons (PY) inhibitory interneurons, which mimic cortical circuits. modeled with electric field strengths that achievable human applications. then simulated intrinsic measured entrainment investigate how modulates ongoing endogenous oscillations. Main results The intensity-specific effects non-linear. At low intensities (<0.3 mV mm −1 ), desynchronizes firing relative higher (>0.3 entrained exogenous field. further explore parameter space find oscillations also depends on frequency by following an Arnold tongue. Moreover, networks amplify tACS-induced via synaptic coupling effects. Our shows PY directly drive neurons. Significance presented this study provide mechanistic framework for understanding intensity- frequency-specific oscillating fields networks. This is crucial rational selection studies

Language: Английский

Citations

Frequency-specific and state-dependent neural responses to brain stimulation DOI

Huichun Luo,

Xiaolai Ye,

Huiting Cai

et al.

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

Cognitive and Neuropathophysiological Outcomes of Gamma-tACS in Dementia: A Systematic Review DOI

Valerio Manippa, Annalisa Palmisano, Michael A. Nitsche

et al.

Neuropsychology Review, Journal Year: 2023, Volume and Issue: 34(1), P. 338 - 361

Published: March 6, 2023

Abstract Despite the numerous pharmacological interventions targeting dementia, no disease-modifying therapy is available, and prognosis remains unfavorable. A promising perspective involves tackling high-frequency gamma-band (> 30 Hz) oscillations involved in hippocampal-mediated memory processes, which are impaired from early stages of typical Alzheimer’s Disease (AD). Particularly, positive effects entrainment on mouse models AD have prompted researchers to translate such findings into humans using transcranial alternating current stimulation (tACS), a methodology that allows endogenous cortical frequency-specific manner. This systematic review examines state-of-the-art use gamma-tACS Mild Cognitive Impairment (MCI) dementia patients shed light its feasibility, therapeutic impact, clinical effectiveness. search two databases yielded 499 records resulting 10 included studies total 273 patients. The results were arranged single-session multi-session protocols. Most demonstrated cognitive improvement following gamma-tACS, some showed neuropathological markers, suggesting feasibility these anyhow far strong evidence available for models. Nonetheless, small number their wide variability terms aims, parameters, measures, make it difficult draw firm conclusions. We discuss methodological limitations studies, proposing possible solutions future avenues improve research dementia.

Language: Английский

Citations

Induced neural phase precession through exogenous electric fields DOI

Miles Wischnewski, Harry Tran, Zhihe Zhao

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 24, 2024

Abstract The gradual shifting of preferred neural spiking relative to local field potentials (LFPs), known as phase precession, plays a prominent role in coding. Correlations between the precession and behavior have been observed throughout various brain regions. As such, is suggested be global mechanism that promotes neuroplasticity. However, causal evidence neuroplastic mechanisms are lacking so far. Here we show link LFP dynamics precession. In three experiments, modulated LFPs humans, non-human primate, computational models using alternating current stimulation. We continuous stimulation motor cortex oscillations humans lead shift maximal corticospinal excitability by ~90°. Further, exogenous induced subset entrained neurons (~30%) primate. Multiscale modeling realistic circuits suggests stimulation-induced driven NMDA-mediated synaptic plasticity. Altogether, experiments provide mechanistic for neocortical process. Alternating current-induced consequently plasticity crucial development novel therapeutic neuromodulation methods.

Language: Английский

Citations

Causal functional maps of brain rhythms in working memory DOI

Miles Wischnewski, Taylor Berger, Alexander Opitz

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(14)

Published: March 27, 2024

Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite plethora of correlative neuroimaging evidence regarding architecture, our understanding critical hubs causally controlling overall performance incomplete. Causal interpretation requires testing following safe, temporal, and controllable neuromodulation specific nodes. Such experiments became available in healthy humans with advance transcranial alternating current stimulation (tACS). Here, we synthesize findings 28 placebo-controlled studies (in total, 1,057 participants) applied frequency-specific noninvasive neural oscillations examined neurotypical adults. We use computational meta-modeling method to simulate each intervention realistic virtual brains test reported behavioral outcomes against stimulation-induced electric fields different brain Our results show stimulating anterior frontal medial temporal theta occipitoparietal gamma rhythms leads significant dose-dependent improvement task performance. Conversely, prefrontal modulation detrimental Moreover, found distinct spatial expression subbands, where changes followed orbitofrontal high-theta low-theta modulation. Finally, all these are driven by accuracy rather than processing time measures. These provide fresh view mechanisms, complementary research, propose hypothesis-driven targets for clinical treatment deficits.

Language: Английский

Citations

Application and research progress of different frequency tACS in stroke rehabilitation: A systematic review DOI

Ding Xue, Yu Zhou, Yang Liu

et al.

Brain Research, Journal Year: 2025, Volume and Issue: 1852, P. 149521 - 149521

Published: Feb. 19, 2025

Language: Английский

Citations

Safety of noninvasive brain stimulation in children DOI

Mohammad Ali Salehinejad, Michael Siniatchkin

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: 37(2), P. 78 - 86

Published: Jan. 3, 2024

Purpose of review Noninvasive brain stimulation (NIBS) is a promising method for altering cortical excitability with clinical implications. It has been increasingly used in children, especially neurodevelopmental disorders. Yet, its safety and applications the developing require further investigation. This aims to provide an overview commonly NIBS techniques including transcranial electrical (tES) magnetic (TMS). Safety data other methods not reported this review. Recent findings In line studies from last decade, 2 years (2022–2023) support children adolescents within currently applied protocols. Both tES TMS are well tolerated, if rules, exclusion criteria, applied. Summary We briefly discussed developmental aspects parameters that need be considered provided up-to-date tES/TMS adolescents. Overall, profile good. For both applications, epilepsy active seizure disorder should criteria prevent potential seizures. Using child-sized earplugs required applications. lack large randomized double-blind trials longitudinal establish children. Video abstract http://links.lww.com/YCO/A78.

Language: Английский

Citations

Prefrontal theta—gamma transcranial alternating current stimulation improves non-declarative visuomotor learning in older adults DOI

Lukas Diedrich,

Hannah I. Kolhoff,

Ivan Chakalov

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 29, 2024

Abstract The rise in the global population of older adults underscores significance to investigate age-related cognitive disorders and develop early treatment modalities. Previous research suggests that non-invasive transcranial Alternating Current Stimulation (tACS) can moderately improve decline adults. However, non-declarative cognition has received relatively less attention. This study investigates whether repeated (16-day) bilateral theta—gamma cross-frequency tACS targeting Dorsolateral Prefrontal Cortex (DLPFC) enhances memory. Computerized training was applied alongside stimulation control for state-of-the-brain. Serial Reaction Time (ASRT) task employed assess functions such as visuomotor skill probabilistic sequence learning. Results from 35 participants aged 55–82 indicated active led more substantial improvements skills immediately after treatment, which persisted 3 months later, compared sham tACS. Treatment benefit pronounced younger age those with pre-existing decline. neither intervention group exhibited modulation These results suggest selectively distinct aspects when DLPFC. Our findings highlight therapeutic potential addressing deficits learning retaining general skills, could have a positive impact on quality life cognitively impaired individuals by preserving independence daily activities.

Language: Английский

Citations

Can non‐invasive brain stimulation modulate peak alpha frequency in the human brain? A systematic review and meta‐analysis DOI

Samantha K. Millard,

Darrah B. Speis,

Patrick Skippen

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(3), P. 4182 - 4200

Published: May 23, 2024

Peak alpha frequency (PAF), the dominant oscillatory within range (8-12 Hz), is associated with cognitive function and several neurological conditions, including chronic pain. Manipulating PAF could offer valuable insight into relationship between various functions potentially providing new treatment avenues. This systematic review aimed to comprehensively synthesise effects of non-invasive brain stimulation (NIBS) on speed. Relevant studies assessing pre- post-NIBS in healthy adults were identified through searches electronic databases (Embase, PubMed, PsychINFO, Scopus, The Cochrane Library) trial registers. risk-of-bias tool was employed for study quality. Quantitative analysis conducted pairwise meta-analysis when possible; otherwise, qualitative synthesis performed. protocol registered PROSPERO (CRD42020190512) Open Science Framework (https://osf.io/2yaxz/). Eleven NIBS included, all a low risk-of-bias, comprising seven transcranial alternating current (tACS), three repetitive magnetic (rTMS), one direct (tDCS) study. Meta-analysis active tACS conditions (eight from five studies) revealed no significant (mean difference [MD] = -0.12, 95% CI -0.32 0.08, p 0.24). Qualitative provided evidence that tDCS altered moderate transient increases 10 Hz rTMS. However, it crucial note small sample sizes used, there substantial variation protocols, most did not specifically target alteration. Further are needed determine NIBS's potential modulating PAF.

Language: Английский

Citations

Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer’s Disease DOI

Maria Luisa De Paolis,

Ilaria Paoletti,

Claudio Zaccone

et al.

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: June 27, 2024

Abstract The last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease (AD) and testing new drugs, with recent FDA approval of two anti-amyloid monoclonal antibodies for AD treatment. Beyond these drug-based experimentations, a number pre-clinical clinical trials are exploring benefits alternative treatments, such as non-invasive stimulation techniques on neuropathology symptoms. Among different brain approaches, transcranial alternating current (tACS) is gaining particular attention due its ability externally control gamma oscillations. Here, we outline knowledge concerning efficacy, safety, ease-of-use cost-effectiveness tACS early advanced AD, applied specifically at 40 Hz frequency, also summarise results validated models ongoing patient-centred trials.

Language: Английский

Citations