Reduction of aversive learning rates in Pavlovian conditioning by angiotensin II antagonist losartan DOI Open Access
Ondrej Zika, Judith E. Appel,

Corinna Klinge

et al.

Published: May 17, 2023

Background: Angiotensin receptor blockade (ARB) has been linked to aspects of aversive learning and memory formation, the prevention post-traumatic stress disorder symptom development. Methods: We investigate influence ARB losartan on Pavlovian conditioning using a probabilistic paradigm. In double-blind, randomised placebo-controlled design, we tested 45 (18 female) healthy volunteers during Baseline session, after application or placebo (Drug session) Follow-up session. On each participants engaged in task where they had predict probability an electrical stimulation every trial while true shock contingencies repeatedly switched between phases high low threat. Computational reinforcement models were used dynamics. Results: Acute administration significantly reduced participants’ adjustment both low-to-high high-to-low threat changes. This was driven by rates group drug session compared baseline. The 50mg dose did not induce reduction blood pressure change reaction times, ruling out general attention engagement. Decreased expectations maintained follow up 24hrs later.Conclusions: study shows that acutely reduces environments. Such decreased may explain previously reported preventive role development anxiety symptoms.

Language: Английский

Reduction of aversive learning rates in Pavlovian conditioning by angiotensin II antagonist losartan DOI Open Access
Ondrej Zika, Judith E. Appel,

Corinna Klinge

et al.

Published: May 17, 2023

Background: Angiotensin receptor blockade (ARB) has been linked to aspects of aversive learning and memory formation, the prevention post-traumatic stress disorder symptom development. Methods: We investigate influence ARB losartan on Pavlovian conditioning using a probabilistic paradigm. In double-blind, randomised placebo-controlled design, we tested 45 (18 female) healthy volunteers during Baseline session, after application or placebo (Drug session) Follow-up session. On each participants engaged in task where they had predict probability an electrical stimulation every trial while true shock contingencies repeatedly switched between phases high low threat. Computational reinforcement models were used dynamics. Results: Acute administration significantly reduced participants’ adjustment both low-to-high high-to-low threat changes. This was driven by rates group drug session compared baseline. The 50mg dose did not induce reduction blood pressure change reaction times, ruling out general attention engagement. Decreased expectations maintained follow up 24hrs later.Conclusions: study shows that acutely reduces environments. Such decreased may explain previously reported preventive role development anxiety symptoms.

Language: Английский

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