Large-scale Signal Propagation Modes in the Human Brain DOI Creative Commons

Youngjo Song,

Pyeong Soo Kim,

Benjamin A. Philip

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract The brain’s large-scale temporal dynamics play a crucial role in understanding its operations, but developing cohesive framework to integrate the potentially extensive array of spatiotemporal patterns remains elusive. Our work addresses this gap by identifying multiple signal propagation modes resting-state fMRI time series under unified methodological framework. We found five distinct that effectively predict future blood-oxygen-level-dependent (BOLD) dynamics, each reconciling transitions between well-known brain networks into coherent units. By utilizing these units, our approach circumvents need explore combinatorial explosion potential states, enabling parsimonious modeling and effective prediction whole-brain evolution. Each mode captures specific operational dimensions neural resource allocation, ensuring their interpretability. Importantly, we showed complex features emerge from superposition few modes, unifying broad spectrum phenomena. results lay groundwork for understand organization. Moreover, individual differences expression profiles correlate with general cognitive abilities, exhibit heritability, demonstrate cross-task stability, underscoring functional significance. This could lead efficient methods characterizing fingerprints advancing diagnostic approaches neurological disorders.

Language: Английский

Multifractal dynamic changes of spontaneous brain activity in psychiatric disorders: Adult attention deficit-hyperactivity disorder, bipolar disorder, and schizophrenia DOI
Sihai Guan, Ziwei Zhang, Chun Meng

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 373, P. 291 - 305

Published: Jan. 5, 2025

Language: Английский

Citations

0
From pre-stimulus activity to the contents of consciousness – A spatiotemporal view: reply to comments on “Beyond task response-Pre-stimulus activity modulates contents of consciousness" DOI
Georg Northoff, Federico Zilio, Jianfeng Zhang

et al.

Physics of Life Reviews, Journal Year: 2025, Volume and Issue: 53, P. 76 - 90

Published: Feb. 26, 2025

Language: Английский

Citations

0
Brain state model: A novel method to represent the rhythmicity of object-specific selective attention from magnetoencephalography data DOI
Chunyu Liu, Xinyue Yang, Xueyuan Xu

et al.

Neurocomputing, Journal Year: 2025, Volume and Issue: unknown, P. 129920 - 129920

Published: March 1, 2025

Language: Английский

Citations

0
Altered brain network dynamics during rumination in remitted depression DOI Creative Commons
Shu Su,

Wenwen Ou,

Mohan Ma

et al.

NeuroImage, Journal Year: 2025, Volume and Issue: unknown, P. 121176 - 121176

Published: March 1, 2025

Language: Английский

Citations

0
Assessing Glymphatic Function, Global Brain Activity, and Cognitive Performance in Adolescents Living With Perinatal HIV Exposure DOI

Xiao Yu,

Lei Gao,

Yin Zhuang

et al.

European Journal of Neuroscience, Journal Year: 2025, Volume and Issue: 61(7)

Published: April 1, 2025

ABSTRACT The discovery of the glymphatic system has provided a theoretical framework for understanding neurofluid dynamics and waste clearance within brain. Recent studies suggest that function is also reflected in resting‐state spontaneous brain activity. However, whether how these functions change perinatally HIV‐infected (PHIV) adolescents, population characterized by neuroviral infection antiviral treatment, largely unknown. This study aims to investigate PHIV‐exposed infected uninfected adolescents exhibit changes activity differ from their healthy, typically developing peers, if are associated with pathways involving related gene receptor expression. Sixteen acquired HIV (HIV+), 18 HIV‐exposed but (HEU), 30 demographically matched (TD) were enrolled. Cognitive, clinical, structural, functional MRI data collected. Diffusion tensor imaging along perivascular space (DTI‐ALPS) was employed characterize function, whole‐brain connectivity based on fMRI used diffusion global oscillatory signals. Further mediation analysis conducted delineate interactive relationships among DTI‐ALPS, signal dynamics, cognitive assessments. HIV+ HEU exhibited comparable DTI‐ALPS scores ( p > 0.05), yet both groups showed significantly higher compared TD peers < 0.05). These findings not only perinatal exposure profoundly impacts subsequent adolescent dynamics.

Language: Английский

Citations

0
Sequential patterning of dynamic brain states distinguish Parkinson’s disease patients with mild cognitive impairments DOI Creative Commons
Aaron S. Kemp,

Andrew J. Eubank,

Yahya Younus

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103779 - 103779

Published: April 1, 2025

Language: Английский

Citations

0
Subsets of cortico-cortical evoked potentials propagate as traveling waves DOI Creative Commons
Justin M. Campbell, Tyler S. Davis, Daria Nesterovich Anderson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 27, 2023

Abstract Understanding the spatiotemporal dynamics of neural signal propagation is fundamental to unraveling complexities brain function. Emerging evidence suggests that cortico-cortical evoked potentials (CCEPs) resulting from single-pulse electrical stimulation may be used characterize patterns information flow between and within networks. At present, basic CCEP cortically subcortically are incompletely understood. We hypothesized evokes traveling waves detectable in three-dimensional space sampled by intracranial stereoelectroencephalography. Across a cohort 21 adult patients with intractable epilepsy, we delivered 17,631 pulses recorded responses 1,019 electrode contacts. The distance each pair contacts was approximated using three different metrics (Euclidean distance, path length, geodesic distance), representing direct, tractographic, transcortical propagation, respectively. For robust CCEP, extracted amplitude-, spectral-, phase-based features identify emanating site stimulation. Many appear propagate as (∼14-28%), despite sparse sampling throughout brain. These stimulation-evoked exhibited biologically plausible velocities (range 0.1-9.6 m/s). Our results reveal direct elicits activity variable dynamics, including initiation waves. Significance Statement Using stimulation, subset were across range distinct but complementary analysis methods. identification help better pathways traversed spontaneous, pathological, or task-evoked distinguish volume-conducted signals.

Language: Английский

Citations

6
What neuroimaging methods can tell us about perceptual development DOI Open Access
Richard Ν. Aslin, Vikranth R. Bejjanki

Published: May 16, 2024

Over the past several decades, behavioral methods suitable for use with human infants have revealed detailed characteristics of perceptual development, but causal mechanisms that drive these changes remain elusive. Neuroimaging hold promise clarifying by reducing hypothesis space theories how biological and experiential factors interact as abilities emerge become refined during early development. Here we review milestones in key areas development infancy childhood, summarize potential value-added neural measures, highlight new analytic techniques can further clarify future. We also outline patterns interaction describe findings change age raise some cautionary notes about to interpret interactions.

Language: Английский

Citations

0
Complex slow waves radically reorganise human brain dynamics under 5-MeO-DMT DOI Creative Commons
George Blackburne, Rosalind McAlpine, Marco S. Fabus

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic drug known for its uniquely profound effects on subjective experience, reliably eradicating the perception of time, space, and self. However, little about how this alters large-scale brain activity. We collected naturalistic electroencephalography (EEG) data 29 healthy individuals before after inhaling high dose (12mg) vaporised synthetic 5-MeO-DMT. replicate work from rodents showing amplified low-frequency oscillations, but extend these findings with novel tools characterising organisation dynamics complex spatiotemporal fields neural find that 5-MeO-DMT radically reorganises flows activity, causing them to become incoherent, heterogeneous, viscous, fleeting, nonrecurring, cease their typical travelling forwards backwards across cortex compared resting state. Further, we consequence reorganisation in broadband which exhibits slower, more stable, low-dimensional behaviour, increased energy barriers rapid global shifts. These provide first detailed empirical account sculpts human dynamics, revealing set cortical slow wave behaviours, significant implications extant neuroscientific models serotonergic psychedelics.

Language: Английский

Citations

0
Large-scale Signal Propagation Modes in the Human Brain DOI Creative Commons

Youngjo Song,

Pyeong Soo Kim,

Benjamin A. Philip

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Abstract The brain’s large-scale temporal dynamics play a crucial role in understanding its operations, but developing cohesive framework to integrate the potentially extensive array of spatiotemporal patterns remains elusive. Our work addresses this gap by identifying multiple signal propagation modes resting-state fMRI time series under unified methodological framework. We found five distinct that effectively predict future blood-oxygen-level-dependent (BOLD) dynamics, each reconciling transitions between well-known brain networks into coherent units. By utilizing these units, our approach circumvents need explore combinatorial explosion potential states, enabling parsimonious modeling and effective prediction whole-brain evolution. Each mode captures specific operational dimensions neural resource allocation, ensuring their interpretability. Importantly, we showed complex features emerge from superposition few modes, unifying broad spectrum phenomena. results lay groundwork for understand organization. Moreover, individual differences expression profiles correlate with general cognitive abilities, exhibit heritability, demonstrate cross-task stability, underscoring functional significance. This could lead efficient methods characterizing fingerprints advancing diagnostic approaches neurological disorders.

Language: Английский

Citations

0