Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141463 - 141463
Published: Sept. 27, 2024
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(5), P. 2434 - 2450
Published: Jan. 29, 2024
Glyoxal is a highly reactive aldehyde widely present in common diet and environment inevitably generated through various metabolic pathways
Language: Английский
Citations
21
Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: 157, P. 104903 - 104903
Published: Feb. 6, 2025
Language: Английский
Citations
2
Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140620 - 140620
Published: July 24, 2024
Language: Английский
Citations
10
Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 7, 2025
ABSTRACT N ‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as potent hepatotoxin, promutagen, and probable human carcinogen; this because of the metabolites associated with its biotransformation. The metabolism NDMA produces formaldehyde, another alkylating agent DBP. Both compounds are generated from natural anthropogenic sources, but safety restrictions applied to do not extend uses formaldehyde. Hence, potential health ecological risks concern. Due limited information on long‐term effects exposure these at environmentally relevant concentrations, work aimed compare transgenerational reproductive developmental toxicity separate exposures or metabolite formaldehyde in Drosophila melanogaster over four generations. parental flies were fed (1.19E−06 5 mM) for 48 h during third larval instar. Subsequent offspring (F1–F3) grown under compound‐free conditions. In generation, both modified time emergence reduced number progenies. NDMA, was lethal, affected fertility, weakly induced malformations. next generations, malformed offspring. Reproductive malformations maintained least three suggesting that detrimental could unexposed This first study reporting individual reproduction development between D. , highlighting relevance evaluating multiple generations accurately determine environmental pollutants.
Language: Английский
Citations
1
Food Chemistry, Journal Year: 2024, Volume and Issue: 450, P. 139315 - 139315
Published: April 10, 2024
Language: Английский
Citations
8
Food Chemistry X, Journal Year: 2025, Volume and Issue: 25, P. 102225 - 102225
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
Reactive carbonyl species (RCS), sourced exogenously and endogenously, can modify proteins to generate advanced glycation end products (AGEs), which lead cell damage various diseases. To date, it has not been reported that two or more RCSs a single amino acid residue in proteins. The aim of the present study is investigate whether how formaldehyde acrolein simultaneously lysine residues resulting adducts are capable binding AGE receptor (RAGE). We found aldehydes comodify bovine serum albumin (BSA), generating novel adduct, 5-formyl-3-methylene-2,6-dihydropyridin-lysine (FMD-lysine). In protein band obtained from SDS-PAGE, modified sites account for 55% 60 BSA when molar ratio BSA: formaldehyde: was 1:10:10. This new adduct identified by mass spectrometry organs mice after inhalation exposure aldehydes. A total 231 FMD modification were detected across heart (35), liver (29), lung (33), kidney (34), hippocampus (38), brain tissues (32), plasma (8), aorta (22). Moreover, N-acetyl-l-lysine-FMD (N-lys-FMD) stimulated RAGE expression RAW264.7 cells than common endogenous AGEs, Nε-carboxymethyl Nε-carboxyethyl lysine. Additionally, BSA-bound induced higher N-lys-FMD. activation FMD-lysine may trigger an inflammatory response vivo. Thus, protein-bound serve as promising target monitoring both exogenous acrolein.
Language: Английский
Citations
0
Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107555 - 107555
Published: March 1, 2025
Language: Английский
Citations
0
Genes, Journal Year: 2025, Volume and Issue: 16(5), P. 471 - 471
Published: April 22, 2025
Background/Objectives: Hatchery fumigation is recognized as a crucial step to control microbial bloom in the environment, and formaldehyde one of most widely used disinfectants ensure successful hatchability healthy production. While many benefits are thought be derived from disinfectant properties, it possible that additional host gene genetic pathway modulation could contribute these outcomes. The current study aimed capture ovo transcriptional response liver tissue treatment. Methods: Chick embryos were subjected treatment for 25 min at 24–25 °C 75% relative humidity, keeping group untreated. On 18th day incubation 37.8 58–63% eggs broken, was obtained RNA isolation, cDNA library preparation, sequencing. Results: Bioinformatics analysis revealed 908 significant differentially expressed genes (DEGs), among which 814 known 94 novel genes. A total 672 DEGs upregulated, whereas 236 downregulated FA Of genes, 80 upregulated. Key DEGs, associated QTLs, transcription factors involved immuno-inflammatory responses, oxidative stress, epigenetic modification, cellular adaptation-related activities. Further research should focus on biological validation key clarify their roles, pathways, relationships Conclusions: Overall, findings (1) provide critical molecular detail first towards selection improve effectiveness, (2) DEG signatures reference against compare other interventions achieve production benefits.
Language: Английский
Citations
0
Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113909 - 113909
Published: May 1, 2025
Language: Английский
Citations
0