In-depth characterisation of a selection of gut commensal bacteria reveals their functional capacities to metabolise dietary carbohydrates with prebiotic potential DOI Creative Commons
Cassandre Bedu-Ferrari, Paul Biscarrat,

Fréderic Pepke

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 17, 2024

ABSTRACT The microbial utilisation of dietary carbohydrates is closely linked to the pivotal role gut microbiome in human health. Inherent modulation complex communities, a prebiotic implies selective specific substrate, relying on metabolic capacities targeted microbes. In this study, we investigated 17 commensal bacteria toward with potential. First, vitro experiments allowed classification bacterial growth and fermentation profiles response various carbon sources, including agave inulin, corn fiber, polydextrose citrus pectin. influence phylogenetic affiliation appeared statistically outweigh sources determining degrees carbohydrate utilisation. Secondly, narrowed our focus six representative Bacteroidetes Firmicutes phyla perform an untargeted HR-LC/MS metabolomic analysis. Bacteroides xylanisolvens , thetaiotaomicron intestinalis Subdoligranulum variabile Roseburia Eubacterium rectale exhibited distinct different sources. relative abundance metabolites was significantly influenced by carbohydrates, these effects being strain-specific and/or carbohydrate-specific. Particularly, findings indicated elevation short-chain fatty acids other metabolites, succinate, gamma-aminobutyric acid, nicotinic acid. These were associated putative health benefits. Finally, RNA-Seq transcriptomic approach provided deeper insights into underlying mechanisms metabolisation. Restricting four bacteria, B. thetaiotaomicron, S. R. did modulate level genes related enzymatic machinery involved metabolisation carbohydrates. This study provides holistic view molecular strategies induced during dynamic interplay between potential bacteria.

Language: Английский

Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review DOI Creative Commons

Oluwatobi Victoria Obayomi,

Abiola Folakemi Olaniran, Stephen Olugbemiga Owa

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 119, P. 106337 - 106337

Published: July 6, 2024

Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to their ability alter gut microbiota an impact on number health disease-related factors, in relation human recent years. are that provide benefits beyond simple sustenance. They contain biologically active ingredients offer additional when consumed regular basis as part balanced diet. Prebiotics, which indigestible fibers specifically promote the growth activity beneficial bacteria, probiotics, live microorganisms upon consumption sufficient amount, shown great promise modifying composition function microbiota. The identified review problem involves clarifying precise impacts immune system function, composition, metabolic health, disease prevention. This emphasizes numerous advantages preserving balance microbiota, boosting immunity, enhancing parameters, reducing risk diseases. also insight advances formulation functional mitigating conditions synergy between prebiotics.

Language: Английский

Citations

42
In-depth characterization of a selection of gut commensal bacteria reveals their functional capacities to metabolize dietary carbohydrates with prebiotic potential DOI Creative Commons
Cassandre Bedu-Ferrari, Paul Biscarrat,

Frédéric Pepke

et al.

mSystems, Journal Year: 2024, Volume and Issue: 9(4)

Published: March 5, 2024

The microbial utilization of dietary carbohydrates is closely linked to the pivotal role gut microbiome in human health. Inherent modulation complex communities, a prebiotic implies selective specific substrate, relying on metabolic capacities targeted microbes. In this study, we investigated 17 commensal bacteria toward with potential. First,

Language: Английский

Citations

7
The Role of Legumes in the Sustainable Mediterranean Diet: Analysis of the Consumption of Legumes in the Mediterranean Population over the Last Ten Years a PRISMA Statement Methodology DOI Open Access

Betty Carlini,

Cristina Lucini-Baquero, Javier Velázquez

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(7), P. 3081 - 3081

Published: April 8, 2024

The Mediterranean model, introduced by Ancel Keys, has gained significant importance from the perspective of sustainability. This is why diet now called a sustainable diet. study focuses on legumes, protein-rich foods vegetable origin, cultivated in area, as their production and use cooking are highly sustainable. analysis covers consumption over last 10 years entire looking specifically at Spain. objectives this work to analyze legumes taking into account fact that they an important environmental well food resource, how changed certain countries bordering relation social cultural changes, with particular attention pandemic. shows how, Spain, since 2020, increased, demonstrating emergency situations, different dietary choices made. In addition, it excellent source protein resource

Language: Английский

Citations

4
Soluble chickpea and lentil powders: A solution for elderly consumers interested in enriching their meals with protein DOI Creative Commons
Celia Badia‐Olmos, Laura Laguna,

Catalina Daniela Igual

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Protein intake in the elderly is often inadequate; one solution to enrich meals with sustainable proteins.

Language: Английский

Citations

0
The Cardioprotective Properties of Pulses and the Molecular Mechanisms of Their Action DOI Open Access
Beata Olas

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1820 - 1820

Published: Feb. 20, 2025

: Legumes and their seeds (pulses) have various nutritional health benefits form an important part of a healthy diet. The present work reviews recent studies from the literature concerning cardioprotective properties legumes, particularly pulses, summarizes molecular basis. was gathered electronic databases, including ScienceDirect, PubMed, SCOPUS, Web Knowledge, Sci Finder, Science, using following terms: "legume seeds", "pulses", "beans", "peas", "broad beans", "chickpea", "lentils", "cardiovascular system", disease", combinations. abstracts any identified articles were initially analyzed to confirm whether they met inclusion criteria. Pulses may reduce risk cardiovascular diseases (CVDs) by mechanisms, altering plasma lipid composition (especially lowering total LDL cholesterol), increasing satiety, reducing inflammation, decreasing oxidative stress blood pressure. It is, however, unclear pulses maintain after processing, more research is needed in this area.

Language: Английский

Citations

0
Positive nutritional selection of adults with healthy lifestyle and high daily fiber consumption for the isolation of beneficial intestinal bacteria: the iTARGET cohort study protocol. DOI Creative Commons
A. Caillé,

Chloé Connan,

Noelle Lyon Belgy

et al.

MethodsX, Journal Year: 2025, Volume and Issue: unknown, P. 103268 - 103268

Published: March 1, 2025

Recent advances in the study of gut microbiota has pointed to its under-utilized source potentially beneficial bacteria, known as next generation probiotics, offering a promising avenue restore or compensate impaired toward healthy state. Aside from difficulties achieve in-lab adequate culture conditions, use bacterial isolates is also limited by their bioavailability donor itself. In iTARGET study, we positively selected donors based on diet enriched fiber, that been shown increase prevalence species associated with health. The monocenter, prospective, observational adults lifestyle and high daily fiber consumption. We aim recruit individuals two phases, first one for all will permit identification carriers bacteria interest second phase subset allow isolation previously identified bacteria. Our primary outcome at least isolate. secondary outcomes comprised throughput metagenomic profiles intestinal characterization cultured isolates. was approved French Research Ethics Committees (Comité de Protection des Personnes Sud-Est I) under National reference ID 2023-A01677-38. Study findings results be published peer-reviewed Open Access journals. (Trial registration number ClinicalTrials.gov: NCT06166810).

Language: Английский

Citations

0
The EAT-Lancet diet associated cardiovascular health parameters: evidence from a Brazilian study DOI Creative Commons
Rosa Sá de Oliveira Neta, Severina Carla Vieira Cunha Lima, Maria Fernanda Araújo de Medeiros

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

The EAT-Lancet diet is a aimed at promoting population and planetary health from the perspective of sustainable diets in terms environmental aspects. This study to assess association between adherence cardiometabolic risk factors among adults elderly individuals capital city northeastern region Brazil.

Language: Английский

Citations

2
In-depth characterisation of a selection of gut commensal bacteria reveals their functional capacities to metabolise dietary carbohydrates with prebiotic potential DOI Creative Commons
Cassandre Bedu-Ferrari, Paul Biscarrat,

Fréderic Pepke

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 17, 2024

ABSTRACT The microbial utilisation of dietary carbohydrates is closely linked to the pivotal role gut microbiome in human health. Inherent modulation complex communities, a prebiotic implies selective specific substrate, relying on metabolic capacities targeted microbes. In this study, we investigated 17 commensal bacteria toward with potential. First, vitro experiments allowed classification bacterial growth and fermentation profiles response various carbon sources, including agave inulin, corn fiber, polydextrose citrus pectin. influence phylogenetic affiliation appeared statistically outweigh sources determining degrees carbohydrate utilisation. Secondly, narrowed our focus six representative Bacteroidetes Firmicutes phyla perform an untargeted HR-LC/MS metabolomic analysis. Bacteroides xylanisolvens , thetaiotaomicron intestinalis Subdoligranulum variabile Roseburia Eubacterium rectale exhibited distinct different sources. relative abundance metabolites was significantly influenced by carbohydrates, these effects being strain-specific and/or carbohydrate-specific. Particularly, findings indicated elevation short-chain fatty acids other metabolites, succinate, gamma-aminobutyric acid, nicotinic acid. These were associated putative health benefits. Finally, RNA-Seq transcriptomic approach provided deeper insights into underlying mechanisms metabolisation. Restricting four bacteria, B. thetaiotaomicron, S. R. did modulate level genes related enzymatic machinery involved metabolisation carbohydrates. This study provides holistic view molecular strategies induced during dynamic interplay between potential bacteria.

Language: Английский

Citations

0