Molecular Signatures DOI
Ankur Bhardwaj, S. Gupta

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 114

Published: Dec. 17, 2024

The discovery of biomarkers has revolutionized the field oncology, providing critical insights into processes tumour initiation and progression. Biomarkers, which can be genetic, proteomic, or metabolic in nature, serve as vital indicators for early cancer detection, prognosis, personalized treatment strategies. Tumour undergoes various stages characterized by alterations microenvironment, angiogenesis, ultimately metastasis. Understanding these at molecular level is crucial identifying reliable biomarkers. Recent advances high-throughput technologies such next-generation sequencing, mass spectrometry, advanced imaging techniques have significantly enhanced ability to discover validate new Despite promising advancements, challenges remain translation biomarker discoveries clinical practice. This chapter provides a detailed current state discovery, highlighting key findings future directions this rapidly evolving field.

Language: Английский

Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma DOI Creative Commons

Yanran Bi,

Xihui Ying, Wanbin Chen

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 1, 2024

Language: Английский

Citations

3
Exploring Fucosylation in Lung Cancer: Mechanisms, Diagnosis, and Therapeutic Strategies DOI Creative Commons
Saima Rafique, Wei Ge, Ziyuan Gao

et al.

Advances in Biomarker Sciences and Technology, Journal Year: 2024, Volume and Issue: 6, P. 174 - 190

Published: Jan. 1, 2024

Lung cancer remains a global health crisis, responsible for significant morbidity and mortality. Late-stage diagnosis often limits treatment options patient survival. Therefore, identifying reliable sensitive biomarkers early detection is crucial. Glycosylation, the addition of glycans to protein/RNA/lipid, vital cellular process. Normal glycosylation regulates healthy cell function, while alterations, particularly in fucosylation sialylation, contribute lung development progression. These aberrant patterns are associated with processes such as immune modulation, migration, proliferation, cell-cell recognition. Fucosylation, specific type glycosylation, frequently altered cancer, high levels detected tumors. Understanding mechanisms behind this holds immense potential. It can pave way novel therapeutic diagnostic tools cancer. By analyzing bodily fluids, it could lead early-stage diagnosis. This review delves into initiation metastasis, proposing promising strategies target mechanisms, aiming inhibit tumor growth disease

Language: Английский

Citations

1
Molecular Signatures DOI
Ankur Bhardwaj, S. Gupta

Advances in medical diagnosis, treatment, and care (AMDTC) book series, Journal Year: 2024, Volume and Issue: unknown, P. 85 - 114

Published: Dec. 17, 2024

The discovery of biomarkers has revolutionized the field oncology, providing critical insights into processes tumour initiation and progression. Biomarkers, which can be genetic, proteomic, or metabolic in nature, serve as vital indicators for early cancer detection, prognosis, personalized treatment strategies. Tumour undergoes various stages characterized by alterations microenvironment, angiogenesis, ultimately metastasis. Understanding these at molecular level is crucial identifying reliable biomarkers. Recent advances high-throughput technologies such next-generation sequencing, mass spectrometry, advanced imaging techniques have significantly enhanced ability to discover validate new Despite promising advancements, challenges remain translation biomarker discoveries clinical practice. This chapter provides a detailed current state discovery, highlighting key findings future directions this rapidly evolving field.

Language: Английский

Citations

0