Chemosensors,
Journal Year:
2024,
Volume and Issue:
12(12), P. 276 - 276
Published: Dec. 21, 2024
Biosensors
are
widely
used
across
industries
such
as
healthcare,
food
safety,
and
environmental
monitoring,
offering
high
stability
sensitivity
compared
to
conventional
methods.
Recently,
origami—the
art
of
folding
2D
structures
into
3D
forms—has
emerged
a
valuable
approach
in
biosensor
development,
enabling
the
creation
shape-changing
devices.
These
origami-based
biosensors
particularly
useful
precision
medicine,
rapid
diagnostics,
resource-limited
settings,
affordable,
highly
precise,
portable
solutions
with
diverse
applications.
Paper
biological
substrates
like
DNA
have
been
integrated
origami
techniques
develop
enhanced
functionality.
The
incorporation
aptamer
both
paper
further
increases
specificity
for
target
detection.
concept
paper-based
originated
from
using
platform
assays,
leading
significant
advancements
design
devices
employ
create
channels
wells
manipulating
samples
detecting
molecules
through
reactions
specific
reagents.
Similarly,
origami,
introduced
2006,
has
revolutionized
by
precise
molecular
systems
tunable
properties.
Paper-based
immense
potential
transform
biosensing
technologies
monitoring.
This
review
explores
their
applications,
including
role
biosensors.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
In
this
study,
we
reported
a
flower-like
Cu
2
O@Ag
SERS
substrate
for
distinguish
three
types
of
cancer
cells
from
white
blood
by
using
machine
learning-assisted
LDA,
after
separating
samples
via
microfluidic
chip.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
97(2), P. 1357 - 1365
Published: Jan. 7, 2025
The
development
of
a
sensory
signal
amplification
approach
is
very
crucial
for
rapid
and
precise
detection
aflatoxin
B1
(AFB1).
However,
such
approaches
remain
scarce
due
to
the
weak
interactions
between
AFB1
sensing
probes.
Herein,
first
example
dual-excitation
fluorescent
platform
antibody-free
reported,
which
assembled
by
an
ordered
π–π
stack
cationic
perylene
derivative
(PTHA)
tris(2,2′-bipyridine)ruthenium(II)
[Ru(bpy3)2+].
Taking
advantage
stepwise
assembly
multiple
binding
sites
nanoprobe,
its
ability
capturing
significantly
improved
driven
noncovalent
interactions.
Interestingly,
mode
with
superposition
self-calibration
activated
in
supramolecular
coassembly
process.
Under
excitation
365
nm
440
nm,
exhibits
specific
recognition
toward
limit
determined
be
0.12
ng
mL–1.
Notably,
demonstrates
exceptional
sensitivity
enhancements
106-fold,
revealing
that
self-calibrated
reference
improves
accuracy
analytical
method
significantly.
applications
our
not
only
crack
problem
via
strategy
but
also
provide
universal
sensitization
ultrasensitive
analysis
complex
environments.
Small Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Herein,
the
scalable
fabrication
of
hierarchical
silicon
structures
featuring
high‐density,
horizontally
super‐aligned
sub‐5
nm
nanowires
(SiNWs),
is
reported.
These
unprecedented,
highly
organized
architectures
with
tunable
sizes
and
densities
are
fabricated
using
straightforward
micro‐patterned
SiO
2
/Si
templates
followed
by
a
chemical
vaporetching
process.
In
time‐resolved
structural
analysis,
it
revealed
that
rapid,
aggressive
etching
crucial
for
creating
an
inhomogeneous
spatial
distribution
vapor
etchants,
inducing
surface
defects
acting
as
preferential
sites
localized
anisotropic
along
<111>
direction.
The
efficacy
this
unique
structure
demonstrated
single‐molecule
detectable
surface‐enhanced
Raman
scattering
sensor,
incorporating
sub‐10
silver
plasmonic
nanoparticles.
Its
distinct
features—marked
quantum‐confined
dimensions,
ultrahigh
area,
dual‐scale
roughness,
exceptional
uniformity—enable
significant
enhancement
optical
response
detection
sensitivity
down
to
10
−11
m
.
controlled
SiNW
architecture
can
broaden
applications
quantum
in
bio‐sensing
other
emerging
technologies.
The
detection
and
quantification
of
veterinary
drug
residues
in
meat
remain
a
significant
challenge
due
to
the
complex
background
interference
inherent
matrix,
which
compromises
stability
accuracy
spectroscopic
analysis.
This
study
introduces
an
advanced
label-free
surface-enhanced
Raman
spectroscopy
(SERS)
platform
for
precise
identification
drugs.
By
employing
dual
enhancement
strategy
involving
sodium
borohydride
activation
calcium
ion-deuterium
oxide
guidance,
this
achieves
efficient
capture
signal
amplification
molecules
on
highly
active
nanoparticles.
High-quality
SERS
spectra
were
obtained
carprofen,
doxycycline
hydrochloride,
chloramphenicol,
penicillin
G
salt,
enabling
accurate
classification
suppression.
In
addition,
application
machine
learning
algorithms,
including
PCA-LDA,
heatmap,
decision
tree
modeling,
allows
differentiation
mixed
samples.
Quantitative
analyses
samples
achieved
through
intensity
ratios
multivariate
curve
resolution-alternate
least-squares
(MCR-ALS)
analysis,
with
results
showing
high
consistency
high-performance
liquid
chromatography
(HPLC)
measurements.
These
findings
highlight
potential
SERS-based
rapid
multicomponent
food
matrices.
