Cited by Lotus seed protein ameliorates hepatic lipid metabolic disorders in high-fat diet-fed mice via activating the PPARα signaling pathway

Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo DOI

Hongzheng Lu,

S. Yang, Wei Li

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 459 - 459

Published: Jan. 31, 2025

Dietary interventions with food-derived natural products have emerged as a promising strategy to alleviate obesity. This study aims investigate the anti-obesity effect of Hericium erinaceus protein (HEP) and its underlying mechanism. Our results demonstrated that HEP exhibited excellent radical scavenging activity in vitro. In vivo, intervention reduced pancreatic lipase intestine enhanced fat excretion, thereby inhibiting absorption dietary fats. Meanwhile, ameliorated body weight organ indexes, dyslipidemia, insulin resistance, hepatic steatosis, liver oxidative stress injuries obese mice. The real-time PCR (qRT-PCR) Western blot analyses indicated upregulated expression peroxisome proliferator-activated receptor α (PPARα), subsequently fatty acid oxidation-related genes (lipoprotein (LPL), carnitine palmitoyltransferase 1a (CPT-1a), acyl-CoA oxidase 1 (ACOX1)) downregulated lipogenesis-related (sterol regulatory element-binding protein-1c (SREBP-1c), stearoyl-coenzyme A desaturase (SCD-1), synthase (FASN)), ameliorating lipid metabolism disorders. Therefore, these findings exerted protective effects on disorders by activating PPARα pathway, indicating potential supplement for prevention amelioration

Language: Английский

Citations

Dietary Triterpenoids in Functional Food and Drug Ingredients: a review of structure-activity relationships, biosynthesis, applications, and AI-driven strategies DOI

Chao Fang, Haixia Yang, Daidi Fan

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104961 - 104961

Published: March 1, 2025

Language: Английский

Citations

Dietary Phytochemicals in Health and Disease: Mechanisms, Clinical Evidence, and Applications—A Comprehensive Review DOI

Md. Sakhawot Hossain, Md Abdul Wazed,

S T Asha

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

ABSTRACT Phytochemicals are bioactive compounds found in plants that play a key role promoting health and preventing diseases. Present fruits, vegetables, grains, seed oils, these considered safe for consumption due to the co‐evolution adaptation between mammals plants. Due their wide‐ranging biological effects, they have attracted considerable research interest. This comprehensive review explores mechanisms of action, benefits, applications dietary phytochemicals, with particular focus on groups such as polyphenols, flavonoids, carotenoids. Research shows phytochemicals interact nuclear membrane receptors, influence metabolic pathways, affect epigenetic modifications. Our highlights broad range activities compounds, including antioxidant, antibacterial, anti‐inflammatory, anti‐diabetic, anticancer all which contribute health‐promoting properties. Clinical evidence supports prevention management diseases cardiovascular disorders, conditions, cancer, diets rich being linked lower risk disease. also at cutting edge food preservation, supplements, emerging medical treatments. Additionally, we identified advancements extraction identification techniques, particularly metabolomics, further enhance areas. Despite promising challenges bioavailability, regulatory barriers, need robust clinical trials persist. However, innovative delivery systems like nanoparticles, liposomes, encapsulation offer potential solutions bioavailability by improving absorption stability. The concludes emphasizing personalized nutrition combination therapies benefits while stressing methods, trials, bioavailability.

Language: Английский

Citations

Coatings Based on Essential Oils for Combating Antibiotic Resistance DOI

Anita Ioana Vișan, Irina Neguț

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 625 - 625

Published: July 4, 2024

In the current era of widespread antimicrobial resistance, utilization essential oils (EOs) derived from plants has emerged as a promising alternative in combating pathogens that have developed resistance to antibiotics. This review explores therapeutic potential valuable tools restoring efficacy antibiotics, highlighting their unique ability affect bacteria multiple ways and target various cellular systems. Despite challenge elucidating precise mode action, EOs shown remarkable results rigorous testing against diverse range bacteria. multifaceted role bacterial microorganisms, emphasizing extraction methods, mechanisms comparative synthetic Key findings underscore strategies deploy counter bacteria, significant differences conventional The extends advanced coating solutions for medical devices, exploring integration EO formulations into these coatings. Challenges developing effective coatings are addressed, along with innovative approaches implementation. An evaluation reveals formidable alternatives traditional antibacterial agents device applications. renaissance natural remedies emphasizes need combine wisdom modern scientific advancements address urgent post-antibiotic era.

Language: Английский

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Anti-obesity potential of chickpea fermented by Lactiplantibacillus sp. (PMS-A6) from salted oyster: UPLC-ESI-Q-TOF-MSE profiling and in-vitro/in-vivo validation DOI

Harshavardhan Mohan,

Pavithra Muthukumar Sathya,

Shweta S Acharya

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 208, P. 116133 - 116133

Published: March 6, 2025

Language: Английский

Citations

Lotus seed protein ameliorates hepatic lipid metabolic disorders in high-fat diet-fed mice via activating the PPARα signaling pathway DOI

H. Chen,

Hongzheng Lu,

Zhenling Lang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104855 - 104855

Published: Aug. 2, 2024

Language: Английский

Citations