Testing sex-biased admixture origin of macaque species using autosomal and X-chromosomal genomic sequences DOI Creative Commons
Naoki Osada, Kazunari Matsudaira,

Yuzuru Hamada

et al.

Genome Biology and Evolution, Journal Year: 2020, Volume and Issue: unknown

Published: Oct. 9, 2020

The role of sex-specific demography in hybridization and admixture genetically diverged species populations is essential to understand the origins genomic diversity sexually reproducing organisms. In order infer how sex-linked loci have been differentiated undergoing frequent admixture, we examined 17 whole-genome sequences seven representing genus Macaca, which shows inter-specific predominantly female philopatry. We found that were prevalent within these species. For three cases suggested hybrid origin species/subspecies, Macaca arctoides, fascicularis ssp. aurea, Chinese mulatta, level X chromosomes, less affected by male-biased migration than autosomes. one case, cyclopis fuscata was closer M. mulatta Indian fuscata/cyclopis more pronounced on chromosome Since mitochondrial genomes cyclopis, cluster together, genome distantly related, observed pattern genetic differentiation X-chromosomal consistent with nuclear swamping hypothesis, strong, continuous introgression from ancestral population a related generated incongruencies between genealogies genomes.

Language: Английский

A lethal mitonuclear incompatibility in complex I of natural hybrids DOI Creative Commons
Ben Moran, Cheyenne Payne, Daniel L. Powell

et al.

Nature, Journal Year: 2024, Volume and Issue: 626(7997), P. 119 - 127

Published: Jan. 10, 2024

The evolution of reproductive barriers is the first step in formation new species and can help us understand diversification life on Earth. These often take form hybrid incompatibilities, which alleles derived from two different no longer interact properly hybrids

Language: Английский

Citations

28
Molecular basis of human nuclear and mitochondrial tRNA 3′ processing DOI Creative Commons
Arjun Bhatta, Bernhard Kuhle,

Ryan D. Yu

et al.

Nature Structural & Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Abstract Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3′ end of both nucleus-encoded (nu-tRNAs) and mitochondria-encoded (mt-tRNAs) is self-sufficient for nu-tRNAs but requires TRMT10C SDR5C1 process most mt-tRNAs. Here we show that specifically facilitate structurally degenerate mt-tRNAs lacking the canonical elbow. Structures in complex with TRMT10C, two divergent mt-tRNA substrates reveal distinct mechanisms pre-tRNA recognition. While are recognized by direct ELAC2–RNA interactions, noncanonical depends on protein–protein interactions between TRMT10C. These results provide molecular basis tRNA nucleus mitochondria explain organelle-specific requirement additional factors. Moreover, they suggest TRMT10C–SDR5C1 evolved as a mitochondrial maturation platform compensate structural erosion bilaterian animals.

Language: Английский

Citations

2
Roles of mitochondria in the hallmarks of metastasis DOI Creative Commons
Adam D. Scheid, Thomas C. Beadnell, Danny R. Welch

et al.

British Journal of Cancer, Journal Year: 2020, Volume and Issue: 124(1), P. 124 - 135

Published: Nov. 4, 2020

Abstract Although mitochondrial contributions to cancer have been recognised for approximately a century, given that DNA (mtDNA) is dwarfed by the size of nuclear genome (nDNA), genetics has represented focal point in biology, often at expense mtDNA and mitochondria. However, genomic sequencing advances vivo models underscore importance mitochondria metastasis. In this review, we explore roles four defined ‘hallmarks metastasis’: motility invasion, microenvironment modulation, plasticity colonisation. Biochemical processes within both cells stromal with which they interact are critical each metastatic hallmark. We unravel complex dynamics cancer, context-dependent capable either promoting metastasis or being leveraged prevent it various points cascade. Ultimately, rooted capacity these organelles tune metabolic genetic responses dynamic microenvironmental cues.

Language: Английский

Citations

83
The role of mitonuclear incompatibilities in allopatric speciation DOI
Ronald S. Burton

Cellular and Molecular Life Sciences, Journal Year: 2022, Volume and Issue: 79(2)

Published: Jan. 29, 2022

Language: Английский

Citations

39
Apomixis and the paradox of sex in plants DOI Creative Commons
Elvira Hörandl

Annals of Botany, Journal Year: 2024, Volume and Issue: 134(1), P. 1 - 18

Published: March 18, 2024

Abstract Background The predominance of sex in eukaryotes, despite the high costs meiosis and mating, remains an evolutionary enigma. Many theories have been proposed, none them being conclusive on its own, they are, part, not well applicable to land plants. Sexual reproduction is obligate embryophytes for great majority species. Scope This review compares main forms sexual asexual ferns angiosperms, based generation cycling sporophyte gametophyte (leaving vegetative propagation aside). benefits maintenance genomic integrity comparison asexuality are discussed light developmental, evolutionary, genetic phylogenetic studies. Conclusions Asexual represents modifications pathway, with various facultative sexuality. For plants, provides direct DNA repair mechanisms oxidative damage reproductive tissues. ploidy alternations meiosis–syngamy cycles prolonged multicellular stages haploid phase gametophytes provide a efficiency purifying selection against recessive deleterious mutations. lineages might buffer effects such mutations via polyploidy can purge mutational load role organelle–nuclear genome compatibility understood. In plants general, mating low because predominant hermaphroditism. Phylogenetic patterns archaeplastid clade suggest that frequencies sexuality concomitant stepwise increase intrinsic extrinsic stress factors. Furthermore, expansion size would potential load. appears be essential keeping long-term integrity, only rare combinations factors allow shifts asexuality.

Language: Английский

Citations

12
Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing DOI Creative Commons
Isabel M. Serrano, Misa Hirose, Charles C. Valentine

et al.

Nature Ecology & Evolution, Journal Year: 2024, Volume and Issue: 8(5), P. 1021 - 1034

Published: Feb. 15, 2024

Mitochondrial genomes co-evolve with the nuclear genome over evolutionary timescales and are shaped by selection in female germline. Here we investigate how mismatching between mitochondrial ancestry impacts somatic evolution of different tissues throughout ageing. We used ultrasensitive duplex sequencing to profile ~2.5 million across five haplotypes three young aged mice, cataloguing ~1.2 ultralow-frequency inherited mutations, which 81,097 unique. identify haplotype-specific mutational patterns several hotspots, including at light strand origin replication, consistently exhibits highest mutation frequency. show that rodents exhibit a distinct spectrum compared primates surfeit reactive oxygen species-associated G > T/C A mutations protein-coding genes signatures negative selection. Lastly, an extensive enrichment reversion 're-align' mito-nuclear within organism's lifespan. Together, our findings demonstrate dynamically evolving subcellular population organismal lifetimes.

Language: Английский

Citations

8
Strong mitonuclear discordance in the phylogeny of Neodermata and evolutionary rates of Polyopisthocotylea DOI
Dong Zhang, Ivan Jakovlić, Hong Zou

et al.

International Journal for Parasitology, Journal Year: 2024, Volume and Issue: 54(5), P. 213 - 223

Published: Jan. 5, 2024

Language: Английский

Citations

6
Mitonuclear Coevolution, but not Nuclear Compensation, Drives Evolution of OXPHOS Complexes in Bivalves DOI Creative Commons
Giovanni Piccinini, Mariangela Iannello, Guglielmo Puccio

et al.

Molecular Biology and Evolution, Journal Year: 2021, Volume and Issue: unknown

Published: Feb. 18, 2021

Abstract In Metazoa, four out of five complexes involved in oxidative phosphorylation (OXPHOS) are formed by subunits encoded both the mitochondrial (mtDNA) and nuclear (nuDNA) genomes, leading to expectation mitonuclear coevolution. Previous studies have supported coadaptation mitochondria-encoded (mtOXPHOS) nuclear-encoded OXPHOS (nuOXPHOS) subunits, often specifically interpreted with regard “nuclear compensation hypothesis,” a specific form coevolution where genes compensate for deleterious mutations due less efficient selection. this study, we analyzed patterns sequence evolution 79 31 bivalve species, taxon showing extraordinary mtDNA variability including species “doubly uniparental” inheritance. Our data showed strong clear signals NuOXPHOS had concordant topologies mtOXPHOS contrary previous phylogenies based on lacking mt interactions. Evolutionary rates between nuOXPHOS were also highly correlated compared non-OXPHO-interacting genes. Nuclear chimeric (I, III, IV, V) higher dN/dS ratios than Complex II, which is exclusively nuDNA-encoded subunits. However, did not find evidence compensation: similar most previously studied bilaterian animals. Moreover, no site-specific compensatory positive selection detected analyses extend new taxonomic group, but propose reconsideration hypothesis.

Language: Английский

Citations

33
Global Patterns of Subgenome Evolution in Organelle-Targeted Genes of Six Allotetraploid Angiosperms DOI Creative Commons
Joel Sharbrough, Justin L. Conover, Matheus Fernandes Gyorfy

et al.

Molecular Biology and Evolution, Journal Year: 2022, Volume and Issue: 39(4)

Published: April 1, 2022

Abstract Whole-genome duplications (WGDs) are a prominent process of diversification in eukaryotes. The genetic and evolutionary forces that WGD imposes on cytoplasmic genomes not well understood, despite the central role cytonuclear interactions play eukaryotic function fitness. Cellular respiration photosynthesis depend successful interaction between 3,000+ nuclear-encoded proteins destined for mitochondria or plastids gene products multi-subunit complexes such as OXPHOS, organellar ribosomes, Photosystems I II, Rubisco. Allopolyploids thus faced with critical task coordinating nuclear genes were inherited from different species. Because share more recent history common descent maternal subgenome than paternal subgenome, “mismatches” allopolyploids might lead to accelerated rates evolution homoeologs allopolyploids, either through relaxed purifying selection strong directional rectify these mismatches. We report evidence six independently formed allotetraploids subgenomes exhibit unequal protein-sequence evolution, but we found no incompatibilities result altered trajectories organelle-targeted genes. analyses content revealed mixed whether lost rapidly non-organelle-targeted Together, global provide insights into complex dynamics showing allopolyploid have separate sharing same nucleus, generation time, ecological context.

Language: Английский

Citations

24
When and why are mitochondria paternally inherited? DOI Creative Commons
Manisha Munasinghe, J. Arvid Ågren

Current Opinion in Genetics & Development, Journal Year: 2023, Volume and Issue: 80, P. 102053 - 102053

Published: May 26, 2023

In contrast with nuclear genes that are passed on through both parents, mitochondrial maternally inherited in most species, of the time. The genetic conflict stemming from this transmission asymmetry is well-documented, and there an abundance population-genetic theory associated it. While occasional or aberrant paternal inheritance occurs, only a few cases where exclusive genomes evolved state. Why remains poorly understood. By examining commonalities between species inheritance, we discuss what they may tell us about evolutionary forces influencing patterns. We end by discussing recent technological advances make exploring causes consequences feasible.

Language: Английский

Citations

15