Egyptian Journal of Medical Human Genetics, Journal Year: 2024, Volume and Issue: 25(1)
Published: Feb. 28, 2024
Language: Английский
Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 313 - 313
Published: March 6, 2025
Advancements in genome sequencing technologies have uncovered the multifaceted roles of long non-coding RNAs (lncRNAs) human cells. Recent discoveries identified lncRNAs as major players gene regulatory pathways, highlighting their pivotal role cell growth and development. Their dysregulation is implicated onset genetic disorders age-related diseases, including cancer. Specifically, they been found to orchestrate molecular mechanisms impacting epigenetics, DNA methylation hydroxymethylation, histone modifications, chromatin remodeling, thereby significantly influencing expression. This review provides an overview current knowledge on lncRNA-mediated epigenetic regulation expression, emphasizing biomedical implications development different types cancers diseases.
Language: Английский
Citations
0
The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(7)
Published: April 8, 2025
ABSTRACT Neuroblastoma (NB) is a pediatric malignancy from the neural crest, where differentiation plays key role in prognosis. We investigated cysteine and glycine‐rich protein 1 (CSRP1) as therapeutic target for NB, it has been linked to carcinogenesis various cancers. Immunohistochemical analysis of archived NB samples showed significant correlation between CSRP1 expression differentiation. Ectopic MYCN ‐amplified BE(2)‐M17 cells increased sensitivity cisplatin, promoted neurite extension, enhanced differentiation, apoptosis, chemosensitivity 13cisRA. Synergistic apoptotic effects were observed with 5‐aza‐2′‐deoxycytidine (DAC) Poly(I:C) treatments SK‐N‐AS implanted xenografts, upregulation CSRP1, innate immune receptor RIG‐I, caspase‐9 activation. was significantly higher mitochondrial DNA‐depleted ρ 0 cells, compared parent cells. Cisplatin further but not Simultaneous caspase‐8 found both cell types, only suggesting that intrinsic extrinsic apoptosis pathways are involved function depending on existence DNA. These findings indicate determination possibly immunity which endows potential enhance 13cisRA, DAC, combination therapies NB.
Language: Английский
Citations
0
Mutation Research/Reviews in Mutation Research, Journal Year: 2025, Volume and Issue: 795, P. 108537 - 108537
Published: Jan. 1, 2025
Language: Английский
Citations
0
BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: May 10, 2025
Porphyromonas gingivalis (P. gingivalis) is closely related to Oral squamous cell carcinoma (OSCC), and P. outer membrane vesicles (OMVs) the main pathogenic factor, which associated with periodontitis, atherosclerosis other diseases. However, few studies have reported an association between OMVs OSCC. The purpose of this study was establish clinical relationship OSCC based on samples. Further, effect observed model in vitro, possible molecular mechanism discussed. Immunohistochemistry used detect abundance its paired paracancer tissues, analyze correlation clinicopathological parameters patients. were isolated observe effects proliferation migration lines. RNA-seq performed expression differentially expressed genes (DEGs) detected by real-time quantitative PCR (RT-qPCR) explore potential mechnism progression. higher than that para-cancerous positively correlated degree tissue differentiation (P = 0.028), T stage < 0.001), 0.011). promoted HN6 cells, CAL27 but had no significant migration. treatment attenuated expressions TNFSF15, ZNF292, ATRX, ASPM KIF20B cells. This suggests may be indicator poor prognosis for down-regulate ASPM, participate occurrence development
Language: Английский
Citations
0
Gynecologic Oncology, Journal Year: 2023, Volume and Issue: 177, P. 14 - 19
Published: Aug. 21, 2023
Language: Английский
Citations
7
British Journal of Cancer, Journal Year: 2024, Volume and Issue: 131(10), P. 1656 - 1667
Published: Oct. 10, 2024
Resistance to chemotherapy, combined with heterogeneity among resistant tumors, represents a significant challenge in the clinical management of triple negative breast cancer (TNBC). By dissecting molecular pathways associated treatment resistance, we sought define patient sub-groups and actionable targets for next-line treatment.
Language: Английский
Citations
2
Molecular Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
2
Nature Cell Biology, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 30, 2024
Language: Английский
Citations
2
BioEssays, Journal Year: 2023, Volume and Issue: 46(2)
Published: Dec. 4, 2023
Mammalian telomeres have evolved safeguards to prevent their recognition as DNA double-stranded breaks by suppressing the activation of various sensing and repair proteins. We shown that telomere-binding proteins TRF2 RAP1 cooperate from undergoing aberrant homology-directed recombination mediating t-loop protection. Our recent findings also suggest mammalian interact with nuclear envelope maintain chromosome stability. interacts lamins through KU70/KU80, disruption function result in rupture, promoting telomere-telomere form structures termed ultrabright telomeres. In this review, we discuss importance interactions between shelterin components telomere homeostasis genome
Language: Английский
Citations
6
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: July 24, 2024
Abstract The mosquito midgut functions as a key interface between pathogen and vector. However, studies of physiology virus infection dynamics are scarce, in Culex tarsalis – an extremely efficient vector West Nile (WNV) nonexistent. We performed single-cell RNA sequencing on Cx. midguts, defined multiple cell types, determined whether specific types more permissive to WNV infection. identified 20 states comprising 8 distinct consistent with existing descriptions Drosophila Aedes aegypti physiology. Most populations were there higher levels (vRNA) enteroendocrine cells, suggesting enhanced replication this population. In contrast, proliferating intestinal stem cells (ISC) had the lowest vRNA, finding ISC proliferation is involved control. ISCs also found have strong transcriptional response infection; genes ribosome structure biogenesis, translation significantly downregulated WNV-infected populations. Notably, we did not detect significant WNV-infection induced upregulation canonical antiviral immune (e.g., AGO2 , R2D2 etc.) at whole-midgut level. Rather, observed positive correlation gene expression vRNA load individual that within high may trigger responses. Our findings establish atlas, provide insight into by characterizing cell-type enhancement/restriction of, to, Author Summary leading cause mosquito-borne disease N. America. highly competent plays central role transmission maintenance nature. It hypothesized permissibility contributes barrier thus impacts ability pathogens mosquito. Additionally, it postulated most important organ respect determining competence. recent publication full genome, conjunction growing body work demonstrating successful application methodologies insect models made possible for us examine cellular composition midgut, therein, resolution. cell-type-specific differences viral variability efficiency patterns differential associated populations, characterized aspects innate tissue
Language: Английский
Citations
1