ExerGeneDB: A physical exercise-regulated differential gene expression database

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2025, Volume and Issue: unknown, P. 101027 - 101027

Published: Jan. 1, 2025

Exercise induces molecular changes that involve multiple organs and tissues. Moreover, these are modulated by various exercise parameters-such as intensity, frequency, mode, duration-as well clinical features like gender, age, body mass index (BMI), each eliciting distinct biological effects. To assist researchers in understanding from a comprehensive perspective includes organs, diverse regimens, range of features, we developed Regulated Genes Database (ExerGeneDB), database exercise-regulated differential genes. ExerGeneDB aggregated publicly available exercise-related sequencing datasets subjected them to uniform quality control preprocessing. The data, encompassing variety types, were organized into specialized Notably, conducted analyses on this collected leveraging curated information accounting for important factors such BMI. has assembled 1692 samples rats mice 4492 human samples. It contains data tissues skeletal muscle, blood, adipose tissue, intestine, heart, liver, spleen, lungs, kidneys, brain, spinal cord, bone marrow, bones. bulk Ribonucleic acid (RNA-seq) (including non-coding RNA (ncRNA) protein-coding RNA), microarray ncRNA single cell RNA-seq data. compiles re-analyzes with focus information. This culminated the creation an interactive regulation website can be found at: https://exergenedb.com.

Language: Английский

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Epigenome–proteome integration in aged skeletal muscle after exercise training

The Journal of Physiology, Journal Year: 2024, Volume and Issue: 603(1), P. 29 - 31

Published: Sept. 19, 2024

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