Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 107771 - 107771
Published: Sept. 1, 2024
Language: Английский
Microorganisms, Journal Year: 2023, Volume and Issue: 11(6), P. 1427 - 1427
Published: May 29, 2023
Microbial communities inhabiting the human body play a crucial role in protecting host against pathogens and inflammation. Disruptions to microbial composition can lead various health issues. transfer therapy (MTT) has emerged as potential treatment option address such Fecal microbiota transplantation (FMT) is most widely used form of MTT been successful treating several diseases. Another vaginal (VMT), which involves transferring from healthy female donor diseased patient's cavity with goal restoring normal composition. However, VMT not extensively studied due safety concerns lack research. This paper explores therapeutic mechanisms discusses future perspectives. Further research necessary advance clinical applications techniques VMT.
Language: Английский
Citations
16
Gut, Journal Year: 2023, Volume and Issue: 73(2), P. 282 - 297
Published: Oct. 26, 2023
Objective We sought to investigate the role of interleukin (IL)-20 in IBD and experimental colitis. Design Experimental colitis was induced mice deficient components IL-20 signal transducer activator transcription (STAT)2 signalling pathways. In vivo imaging, high-resolution mini-endoscopy histology were used assess intestinal inflammation. further RNA-sequencing (RNA-Seq), RNAScope Gene Ontology analysis, western blot analysis co-immunoprecipitation, confocal microscopy epithelial cell (IEC)-derived three-dimensional organoids underlying molecular mechanisms. Results validated using samples from patients with non-IBD control subjects by a combination RNA-Seq, immunostainings. IBD, IL20 levels during remission significantly higher antitumour necrosis factor responders versus non-responders. IL-20RA IL-20RB present on IECs IL-20-induced STAT3 suppressed interferon (IFN)-STAT2 these cells. dextran sulfate sodium (DSS)-induced mucosal healing, main producers IL-20. Compared wildtype controls, Il20 −/− , Il20ra Il20rb more susceptible DSS-induced deficiency associated increased IFN/STAT2 activity IFN/STAT2-induced necroptotic death IEC-derived could be markedly blocked Moreover, newly generated Stat2 ΔIEC mice, lacking STAT2 IECs, less compared controls administration animals. Conclusion healing interfering pathway IECs. These results indicate new directions for suppressing gut inflammation modulating IL-20-controlled signals.
Language: Английский
Citations
14
Molecular Biomedicine, Journal Year: 2022, Volume and Issue: 3(1)
Published: Nov. 28, 2022
Abstract People with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing severe clinical outcomes remain be understood. Emerging evidence suggests associations between the gut microbiome and severity progression COVID-19. To better understand host-microbiota interactions in COVID-19, we characterized intestinal patients active comparison recovered uninfected healthy controls. We performed 16S rRNA sequencing stool samples collected May 2020 January 2021 from 20 COVID-19-positive patients, COVID-19-recovered subjects had altered community characteristics compared control subjects, as assessed by both α- β-diversity differences. In observed depletion Bacteroidaceae, Ruminococcaceae, Lachnospiraceae, well decreased relative abundances genera Faecalibacterium, Adlercreutzia , Eubacterium brachy group. The enrichment Prevotellaceae continued after viral clearance; antibiotic use induced further microbiota perturbations patients. conclusion, present that induces dysbiosis particular populations commensal bacteria, phenomenon heightened exposure, general effects do not persist post-recovery.
Language: Английский
Citations
19
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 9
Published: Jan. 20, 2023
The prevalence of celiac disease increased in recent years. In addition to the genetic and immunological factors, it appears that environmental determinants are also involved pathophysiology disease. Gastrointestinal infections impact development Current research does not directly confirm protective effect natural childbirth breastfeeding on However, seems genetically predisposed children, amount gluten introduced into diet may have an development. Also western lifestyle, including dietary patterns high fat, sugar, gliadin, potentially increase risk due changes intestinal microbiota, permeability, or mucosal inflammation. Further is needed expand knowledge relationship between factors define evidence-based preventive interventions against manuscript summarizes current predisposing associated with lifestyle.
Language: Английский
Citations
11
Microbial Cell, Journal Year: 2024, Volume and Issue: 11, P. 106 - 115
Published: April 6, 2024
Abstract Gut microbiota has complex immune functions, related to different pathologies, including multiple sclerosis (MS).This study evaluated the influence of treatments on gut in people with MS (PwMS). The research comprised 60 participants, 39 PwMS and 21 healthy controls (HC). Among PwMS, 20 were prescribed a disease-modifying therapy (DMT), either interferon beta1a or teriflunomide, while 19 received combination classical DMT an immunoglobulin Y (IgY) supplement. For each participant, two sets samples collected: one at study's outset another after months. Alpha beta diversity analyses revealed no significant differences between groups. In comparison HC, group exhibited increase Prevotella stercorea decrease Faecalibacterium prausnitzii . Following treatment, individuals showed enrichment Lachnospiraceae Streptococcus second sample, compared first one, demonstrated Bifidobacterium angulatum Oscillospira for MS. is not significantly HC. However, specific taxonomic changes indicate presence dysbiosis state. use DMTs supplements may contribute alterations microbial composition, potentially leading restoration healthier microbiome.
Language: Английский
Citations
4
Microbiome, Journal Year: 2025, Volume and Issue: 13(1)
Published: Jan. 27, 2025
Numerous studies have confirmed a close relationship between the pathogenicity of influenza and respiratory microbiota, but mechanistic basis for this is poorly defined. Also, majority these been conducted on murine models, it remains unclear how far findings can be extrapolated from models to other animals. Considering that A virus increasingly recognized as an important canine pathogen, study investigated cross-talk nasal lung tissues mediated by microbes its association with susceptibility in beagle dog model. Using 16S rRNA gene sequencing, combined comparative transcriptomic, anatomical, histological examinations, we viral presence, expression profiles, microbiota cavity after infection beagles antibiotic-induced dysbiosis. Our data showed dysbiosis microbiome exacerbates influenza-induced disease epithelial barrier disruption, impairs host antiviral responses lung. Moreover, dysregulation disturbance microbiota. Further, also identified strain Lactobacillus plantarum isolated significant effect vitro, found activity might associated activation interferon (IFN) pathway modulation impaired autophagy flux induced infection. investigation reveals exerts prominent impact responses, inflammation thresholds, mucosal integrity during Lactobacilli, part may contribute defenses modulating IFN pathways. Collectively, underscores importance homeostasis maintaining health.
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(4), P. 413 - 413
Published: Feb. 8, 2025
Background: The bacterial gut microbiome has been the subject of many studies that have provided valuable scientific conclusions. However, different populations microorganisms interact with each other to maintain homeostasis coexist inside gut. virome, especially, appears play a key role in this interactive microenvironment. Intestinal viral communities, including bacteriophages, appear influence health and disease, although their not yet fully elucidated. In addition, bacteriophages or viruses infect bacteria regulate growth, thus shaping composition affecting immune system. Infant Gut Virome: during first years life significant maturation infant’s contrast, early dysbiosis associated chronic, metabolic autoimmune, disorders later life. Purpose: Although shown be potential triggers autoimmune diseases, there is gap literature regarding infant virome autoimmunity development. Despite lack evidence, review attempts summarize clarify what known so far about timely important topic hope its findings will contribute future research.
Language: Английский
Citations
0
Exploration of Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 11, 2025
Coronavirus disease 2019 (COVID-19) infected individuals showed either mild symptoms or were paucisymptomatic, with severe impact on human health, revealing heightened risk and direct effects health. Among various factors contributing to complications, bacterial fungal co-infection remains very common is highly lethal. This narrative review aims focus the collective role of gut microbiota mycobiota in COVID-19. Fungal infection has been identified as a key factor for spread COVID-19 mortality. Gut mycobiomes diversity abundance also vary due different types SARS-CoV-2 variant infection. Their cross-talk plays vital immune regulation severity, an emphasis understanding altered condition predictive marker. On other hand, microbiome well known shaping metabolic functions, generating responses, deciphering signal decide healthy state individual. Immune response during was linked metabolites produced by microflora, specifically amino acids, sugar metabolites, neurotransmitters. The between clinical implications terms early detection, identification even therapeutic alternatives will open newer avenues. A deep dive mycobiome, their take scientific discovery knowledge develop gut-targeted safe approaches form FMT (fecal transplantation) probiotics, peptides, antibacterial, antifungal metabolites. Overall interplay are critical determinants host immunity, providing insights into home lessons better management crisis future.
Language: Английский
Citations
0
Trends in Parasitology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(16)
Published: April 16, 2025
Many enteric viruses benefit from the microbiota. In mice, microbiota depletion reduces infection by noroviruses and picornaviruses. However, Reovirales are outliers among viruses. Rotavirus is inhibited bacteria, we determined that several reovirus strains have enhanced replication following depletion. Here, focused on an isogenic pair of reoviruses opposing outcomes after Microbiota strain T3SA+ but increases T3SA−. These differ a single amino acid polymorphism in σ1 attachment protein, which confers sialic binding to T3SA+. Sialic facilitates intestinal endothelial cells, while T3SA− inefficiently infects epithelial cells due restriction microbiota-driven, host-derived type III interferon responses. This study enhances understanding interactions viruses, microbiota, tropism, antiviral
Language: Английский
Citations
0