Eat or Be Eaten: Strategies Used by Legionella to Acquire Host-Derived Nutrients and Evade Lysosomal Degradation

Infection and Immunity, Journal Year: 2023, Volume and Issue: 91(4)

Published: March 13, 2023

To replicate within host cells, bacterial pathogens must acquire host-derived nutrients while avoiding degradative antimicrobial pathways. Fundamental insights into pathogenicity have been revealed by bacteria of the genus Legionella, which naturally parasitize free-living protozoa establishing a membrane-bound replicative niche termed Legionella-containing vacuole (LCV). Biogenesis LCV and intracellular replication rely on rapid evasion endocytic pathway acquisition nutrients, much is mediated effector proteins translocated cells Dot/Icm type IV secretion system. Billions years co-evolution with eukaryotic hosts broad tropism resulted in expansion Legionella genome to accommodate massive repertoire that promote biogenesis, safeguard from endolysosomal maturation, mediate nutrients. This minireview focused mechanisms an ancient pathogen leverages hijacks cell biology obtain essential prevent lysosomal degradation.

Language: Английский

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Wolbachia interferes with Zika virus replication by hijacking cholesterol metabolism in mosquito cells

Microbiology Spectrum, Journal Year: 2023, Volume and Issue: 11(6)

Published: Oct. 9, 2023

ABSTRACT Zika virus is a member of the arbovirus Flaviviridae family transmitted by Aedes mosquitos and it associated with microcephaly in infants born to infected mothers. Wolbachia an intracellular gram-negative alpha-proteobacteria that infects many species arthropods, including mosquitos. The presence has been shown control vector population suppress transmission. One mechanism -mediated interference replication competition over host resources between virus. We hypothesize cholesterol metabolism involved suppression due its important role replication. In this study, we determined impacted altering biosynthesis albopictus C6/36 cells, diverting from cell mevalonate (MVA) pathway fulfill needs bacteria. This resulted decrease total cholesterol, increased loads, decreased viral titers. Inhibition MVA using fluvastatin titers, mimicking effects on Wolbachia- free cells. also found cells had depleted lipid droplets, main component which esters. confirmed esterases were upregulated response infection Functional analysis showed alteration simulated inhibition Our study provides behind -induced could help advance strategies pathogens insect vectors human infections. IMPORTANCE Arthropod-borne viruses are emerging spread widely can infect humans be mother fetus, potentially leading infants. promising strategy prevent disease caused arboviruses target population. Recent field studies have mosquito populations bacteria Here, describe how redirect within their at cellular level. Understanding populations.

Language: Английский

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Experimental evolution under different nutritional conditions changes the genomic architecture and virulence of Acinetobacter baumannii

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 5, 2024

Language: Английский

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Maltodextrin-derived nanoparticle resensitizes intracellular dormant Staphylococcus aureus to rifampicin

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122843 - 122843

Published: Oct. 9, 2024

Language: Английский

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A novel antibacterial immune activator: Bi-MOF acts as H2S scavenger to suppress HIF-1α S-sulfhydration and alleviate implant-associated infection

Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102334 - 102334

Published: June 11, 2024

Language: Английский

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