Nutrition-induced changes in the microbiota can cause dysbiosis and disease development

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Eukaryotic organisms are associated with complex microbial communities. Changes within these communities have been implicated in disease development. Nonetheless, it remains unclear whether changes a cause or consequence of disease. Here, we report causal link between environment-induced shifts the microbiota and Using model organism Hydra, observed composition when transferring laboratory-grown Hydra to natural lake environments. These were caused not only by new colonizers, through process community coalescence (merging previously separate communities), but also water nutrients. Moreover, selective manipulation nutrient environment induced compound-specific followed Finally, L-arginine supplementation alone transition Pseudomonas from symbiotic pathogenic, leading an upregulation immune response genes, tissue degradation, host death. findings challenge notion that host-associated is exclusively controlled host, highlighting dynamic interplay epithelial environment, colonizer pool, conditions surrounding water. Furthermore, our results show overfeeding allows for uncontrolled growth versatile interactions host. Environmental may thus render symbionts potential hazard their hosts, blurring divide pathogenic non-pathogenic microbes.IMPORTANCEThis study highlights critical need understand environmental factors obtain holistic view on organismal health. Our demonstrate ecosystem-wide trafficking (community coalescence) reshape profound implications By exploring nutrient-driven composition, research finds experimental support "overfeeding hypothesis," which states alters functionality such overabundance nutrients can facilitate development, transforming microbes into pathogens. emphasize role metabolic driving pathogenicity. provides empirical evidence "pathogenic potential" concept, challenging traditional distinctions supporting idea any microbe become under certain conditions.

Language: Английский

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Competition for shared resources increases dependence on initial population size during coalescence of gut microbial communities

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(11)

Published: March 10, 2025

The long-term success of introduced populations depends on both their initial size and ability to compete against existing residents, but it remains unclear how these factors collectively shape colonization dynamics. Here, we investigate population (propagule) shapes the outcome community coalescence by systematically mixing eight pairs in vitro microbial communities at ratios that vary over six orders magnitude, compare our results neutral ecological theory. Although composition resulting cocultures deviated substantially from expectations, each coculture contained species whose relative abundance depended propagule even after ~40 generations growth. Using a consumer–resource model, show this dose-dependent can arise when resident have high niche overlap consume shared resources similar rates. Strain isolates displayed longer-lasting dose dependence into diverse than pairwise cocultures, consistent with model’s prediction should larger, more persistent effects communities. Our model also successfully predicted resource-utilization profiles, as inferred growth spent media untargeted metabolomics, would stronger coculture. This work demonstrates transient, dynamics emerge resource competition exert outcomes coalescence.

Language: Английский

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Linking microbial community coalescence to ecological diversity, community assembly and species coexistence in a typical subhumid river catchment in northern China

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 938, P. 173367 - 173367

Published: May 23, 2024

Language: Английский

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Engineering the mangrove soil microbiome for selection of polyethylene terephthalate-transforming bacterial consortia

Trends in biotechnology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Cattle Slurry Application Increases Soil Ecosystem Resistance to Flooding

Published: Jan. 1, 2025

Language: Английский

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Sowing success: ecological insights into seedling microbial colonisation for robust plant microbiota engineering

Trends in Plant Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Spatio-temporal scales of the Chinese Daqu microbiome: heterogeneity, niche differentiation, and assembly mechanisms

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104832 - 104832

Published: Dec. 1, 2024

Language: Английский

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Plastic debris mediates bacterial community coalescence by breaking dispersal limitation in the sediments of a large river

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124603 - 124603

Published: July 22, 2024

Language: Английский

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Flooding Promotes the Coalescence of Microbial Community in Estuarine Habitats

Marine Environmental Research, Journal Year: 2024, Volume and Issue: 202, P. 106735 - 106735

Published: Sept. 3, 2024

Language: Английский

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Metagenomics-assembled analysis revealed the characteristics of antibiotic resistome and community coalescence in the soils irrigated with different irrigation materials

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 907, P. 167868 - 167868

Published: Oct. 15, 2023

Language: Английский

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