Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities

Nature Reviews Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

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Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(3), P. 316 - 327

Published: July 5, 2024

Language: Английский

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Jianwei Xiaoshi oral liquid attenuates high-calorie diet-induced dyspepsia in immature rats via regulating the pancreatic secretion pathway and maintaining the homeostasis of intestinal microbiota

Chinese Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 4, 2025

Abstract Background Jianwei Xiaoshi oral liquid (JWXS), a classical traditional prescription comprising various edible medicinal plants, has demonstrated significant efficacy in treating paediatric indigestion. It originates from Jianpi Pill, which is developed the Ming Dynasty and nourishes spleen regulates gastrointestinal function. However, specific molecular mechanisms involved remain unclear. Methods To elucidate material base of JWXS its underlying mechanism dyspepsia, UHPLC–Q–Orbitrap HRMS method network pharmacology were utilized. This was followed by pharmacological experiments, transcriptomics analyses gut microbiota studies to further investigate effects on dyspepsia. Results A total 105 compounds, mainly flavonoids, alkaloids, organic acids cyclic peptides, identified. According five principles generic drug properties, 43 candidate compounds screened out. Their verified through gastric emptying intestinal propulsion experiments. Transcriptomic analysis revealed that primarily alleviated dyspepsia symptoms regulating secretion 8 key proteins pancreatic pathway. The differences microbiota, as identified 16S rRNA ITS2 sequencing, subsequently more pronounced than those observed bacterial model group. In total, 15 differential bacteria 16 fungi Targeted metabolomics SCFAs decrease valeric acid (VA), acetic (AA), isovaleric (IVA) levels group, restored corresponding after administration JWXS. Correlation VA, AA, IVA positively correlated with Lactobacillus Bacteroide s, negatively Aspergillus Candida . suggested might alleviate indigestion composition increasing variety quantity beneficial bacteria, reducing fungal contamination, body. Conclusion improved functional immature rats via involving regulation pathway amelioration flora disorders. Graphical

Language: Английский

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Preparation, Physicochemical Properties, and Specific Properties of the Gut Mycobiota Associated with the Anti-Hepatic Steatosis Benefit of Microcrystalline Propionylated Starch

Published: Jan. 1, 2025

Propionate-acylated resistant starch has garnered attention for its unique ability to infuse specific SCFAs in the distal colon. Here, MPS with an elevated level of was first prepared. Then, how affects hepatic steatosis and gut mycobiome investigated mice. Specifically, microcrystalline pea starch, serving as starting material, underwent esterification propionic anhydride produce MPS. With supplementation anhydride, novel characteristic peaks were observed relative crystallinity increased, according FT-IR XRD analysis, respectively. Moreover, content increased from 64.38% MPS1 (DS 0.0505) 93.26% MPS5 0.2511). Additionally, decreased intestinal dysfunction HFD-fed mice acid faeces mice, indicating that introduced propionyl groups successfully delivered colon improved lipid metabolism. Fungal‐specific internal transcribed spacer amplicon sequencing revealed modified composition increases Penicillium Colletotrichum, which are linked anti-hepatic benefit. Overall, can propionate, modulate mycobiome, benefits.

Language: Английский

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Lipidomics-based Plasma Signature of Alcohol-Related Hepatitis Linked to Short-Term Mortality

JHEP Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101367 - 101367

Published: March 1, 2025

Language: Английский

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Fatty acid composition in the vaginal tract of cis-gender women: canary in coal mines for reproductive health?

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 3, 2025

Abstract The vaginal tract of cis-gender women reproductive age is inhabited by communities bacteria generally dominated one four Lactobacillus species. These are important for the health and favor better outcomes, including fertility, pregnancy leading to term protection against infections. Past studies have focused on role carbohydrates in balance communities, fatty acids has been underestimated. However, small- long-chain present few properties that, combination with sugar metabolism, affect outcomes or disease within communities. Herein, we explore origins as well their roles bacterial life cycle this environment. We also detail putative impact FAs S. aureus , etiologic agents aerobic vaginitis. Finally, discuss potential prevention therapy age.

Language: Английский

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Microplastics Reduced the Natural Attenuation of Antibiotic Resistance Genes in Fertilized Soils

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126144 - 126144

Published: March 1, 2025

Language: Английский

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Activation of YAP/TAZ by gut microbiota via Wnt/β-catenin signaling in cancer development

Academia molecular biology and genomics., Journal Year: 2025, Volume and Issue: 2(2)

Published: April 1, 2025

This review examines the role of gut microbiota in activation Wnt/β-catenin signaling pathway and its impact on cancer progression via YAP/TAZ activation. Yes-associated protein, YAP, is a transcriptional coactivator involved regulating gene expression cell proliferation by interacting with TEA domain (TEAD) transcription factor Hippo pathway. The an evolutionarily conserved that important for development tissue homeostasis but was described as driving oncogenic processes through activity. In this regard, metabolites drove tumor activating onto increased evidence. discusses recent studies modulation effect further pursues effects treatment prevention.

Language: Английский

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Clostridium butyricum Ameliorates Post-Gastrectomy Insulin Resistance by Regulating the mTORC1 Signaling Pathway Through the Gut-Liver Axis

Microbiological Research, Journal Year: 2025, Volume and Issue: unknown, P. 128154 - 128154

Published: April 1, 2025

Language: Английский

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Opportunities in exploring chemical biology tools for better strategies against Candida albicans

Current Opinion in Chemical Biology, Journal Year: 2025, Volume and Issue: 86, P. 102595 - 102595

Published: April 6, 2025

Language: Английский

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