Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction

Neuroscience & Biobehavioral Reviews, Journal Year: 2007, Volume and Issue: 32(3), P. 581 - 597

Published: Dec. 5, 2007

Language: Английский

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Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

Pharmacology & Therapeutics, Journal Year: 2008, Volume and Issue: 120(2), P. 102 - 128

Published: Aug. 16, 2008

Language: Английский

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Natural rewards, neuroplasticity, and non-drug addictions

Neuropharmacology, Journal Year: 2011, Volume and Issue: 61(7), P. 1109 - 1122

Published: April 9, 2011

Language: Английский

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Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders

The Lancet Neurology, Journal Year: 2009, Volume and Issue: 8(12), P. 1140 - 1149

Published: Nov. 12, 2009

Language: Английский

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Sex differences in the neurobiology of drug addiction

Experimental Neurology, Journal Year: 2014, Volume and Issue: 259, P. 64 - 74

Published: Feb. 6, 2014

Language: Английский

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The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review)

International Journal of Molecular Medicine, Journal Year: 2017, Volume and Issue: 39(6), P. 1338 - 1346

Published: April 21, 2017

Signaling pathways are critical modulators of a variety physiological and pathological processes, the abnormal activation some signaling can contribute to disease progression in various conditions. As result, have emerged as an important tool through which occurrence development diseases be studied, may then lead novel drugs. Accumulating evidence supports key role for extracellular signal-regulated kinase 1/2 (ERK1/2) embryonic central nervous system (CNS) regulation adult brain function. ERK1/2, one most well characterized members mitogen-activated protein family, regulates range from metabolism, motility inflammation, cell death survival. In system, ERK1/2 synaptic plasticity, repair memory formation. is also potent effector neuronal neuroinflammation many CNS diseases. This review summarizes recent findings neurobiological research, with special emphasis on that clarify our understanding processes regulate plethora isoform-specific ERK functions under Finally, we suggest potential therapeutic strategies associated agents acting prevent or treat neurological

Language: Английский

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Cell Surface AMPA Receptors in the Rat Nucleus Accumbens Increase during Cocaine Withdrawal But Internalize after Cocaine Challenge in Association with Altered Activation of Mitogen-Activated Protein Kinases

Journal of Neuroscience, Journal Year: 2007, Volume and Issue: 27(39), P. 10621 - 10635

Published: Sept. 26, 2007

Although some studies report increased responsiveness of nucleus accumbens (NAc) AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others decreased plus challenge. Here we examine this apparent contradiction by quantifying cell surface and intracellular AMPAR subunits in the NAc before a challenge injection behaviorally sensitized rats. Because MAPKs (mitogen-activated protein kinases) regulate trafficking are implicated addiction, also evaluated phosphorylation extracellular signal-regulated kinase (ERK), c-Jun N-terminal (JNK), p38. Glutamate receptor 1 (GluR1) GluR2 surface/intracellular (S/I) ratios were 14 d rats but 24 h with (which elicited locomotor response) or saline conditioned locomotion). These findings suggested redistribution GluR1/2-containing receptors, possibility supported immunoprecipitation experiments indicating that most AMPARs GluR1/2 GluR2/3, few homomeric GluR1 GluR1/3 receptors. In rats, ERK during normalized JNK withdrawal, challenge, it was inversely related to S/I ratios. After p38 increased. summary, expression internalized single reexposure cocaine-related cues. paralleled expression. results complex, may be involved internalization respectively.

Language: Английский

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Cocaine‐induced neuroadaptations in glutamate transmission

Annals of the New York Academy of Sciences, Journal Year: 2010, Volume and Issue: 1187(1), P. 35 - 75

Published: Jan. 8, 2010

A growing body of evidence indicates that repeated exposure to cocaine leads profound changes in glutamate transmission limbic nuclei, particularly the nucleus accumbens. This review focuses on preclinical studies cocaine-induced behavioral plasticity, including sensitization, self-administration, and reinstatement seeking. Behavioral, pharmacological, neurochemical, electrophysiological, biochemical, molecular biological associated with plasticity systems are reviewed. The ultimate goal these lines research is identify novel targets for development therapies craving addiction. Therefore, we also outline progress prospects modulators treatment

Language: Английский

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Role of ventral medial prefrontal cortex in incubation of cocaine craving

Neuropharmacology, Journal Year: 2008, Volume and Issue: 56, P. 177 - 185

Published: May 9, 2008

Language: Английский

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The epigenetic landscape of addiction

Annals of the New York Academy of Sciences, Journal Year: 2011, Volume and Issue: 1216(1), P. 99 - 113

Published: Jan. 1, 2011

Drug‐induced alterations in gene expression throughout the reward circuitry of brain are likely components persistence drug‐addicted state. Recent studies examining molecular mechanisms controlling drug‐induced transcriptional, behavioral, and synaptic plasticity have indicated a direct role for chromatin remodeling regulation stability drug‐mediated neuronal programs, subsequent promulgation addictive behaviors. In this review, we discuss recent advances our understanding phenomena—or epigenetics, by one definition—that contribute to drug addiction, with hope that such mechanistic insights may aid development novel therapeutics future treatments addiction.

Language: Английский

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