MicroRNA Expression Changes during Interferon-Beta Treatment in the Peripheral Blood of Multiple Sclerosis Patients DOI Open Access
Michael Hecker, Madhan Thamilarasan, Dirk Koczan

et al.

International Journal of Molecular Sciences, Journal Year: 2013, Volume and Issue: 14(8), P. 16087 - 16110

Published: Aug. 5, 2013

MicroRNAs (miRNAs) are small non-coding RNA molecules acting as post-transcriptional regulators of gene expression. They involved in many biological processes, and their dysregulation is implicated various diseases, including multiple sclerosis (MS). Interferon-beta (IFN-beta) widely used a first-line immunomodulatory treatment MS patients. Here, we present the first longitudinal study on miRNA expression changes response to IFN-beta therapy. Peripheral blood mononuclear cells (PBMC) were obtained before initiation well after two days, four one month, from patients with clinically isolated syndrome (CIS) relapsing-remitting (RRMS). We measured 651 mature miRNAs about 19,000 mRNAs parallel using real-time PCR arrays Affymetrix microarrays. observed that up-regulation IFN-beta-responsive genes accompanied by down-regulation several miRNAs, members mir-29 family. These differentially expressed found be associated apoptotic processes IFN feedback loops. A network miRNA-mRNA target interactions was constructed integrating information different databases. Our results suggest miRNA-mediated regulation plays an important role mechanisms action IFN-beta, not only but also normal immune responses. levels may serve biomarker effects therapy predict individual disease activity progression.

Language: Английский

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review DOI
Mark J. Millan

Progress in Neurobiology, Journal Year: 2017, Volume and Issue: 156, P. 1 - 68

Published: March 18, 2017

Language: Английский

Citations

139
Blood Biomarkers for Stroke Diagnosis and Management DOI
Joseph Kamtchum‐Tatuene, Glen C. Jickling

NeuroMolecular Medicine, Journal Year: 2019, Volume and Issue: 21(4), P. 344 - 368

Published: March 4, 2019

Language: Английский

Citations

138
Epigenetics in Alzheimer’s Disease: Perspective of DNA Methylation DOI
Talal Jamil Qazi, Zhenzhen Quan, Asif Mir

et al.

Molecular Neurobiology, Journal Year: 2017, Volume and Issue: 55(2), P. 1026 - 1044

Published: Jan. 14, 2017

Language: Английский

Citations

135
Epigenetics of Early-Life Lead Exposure and Effects on Brain Development DOI

Marie-Claude Senut,

Pablo Cingolani, Arko Sen

et al.

Epigenomics, Journal Year: 2012, Volume and Issue: 4(6), P. 665 - 674

Published: Dec. 1, 2012

The epigenetic machinery plays a pivotal role in the control of many body's key cellular functions. It modulates an array pliable mechanisms that are readily and durably modified by intracellular or extracellular factors. In fast-moving field neuroepigenetics, it is emerging faulty gene regulation can have dramatic consequences on developing CNS last lifetime perhaps even affect future generations. Mounting evidence suggests environmental factors impact brain through these this report reviews examines effects one most common neurotoxic pollutants our environment, which believed to no safe level exposure during human development: lead.

Language: Английский

Citations

128
MicroRNA Expression Changes during Interferon-Beta Treatment in the Peripheral Blood of Multiple Sclerosis Patients DOI Open Access
Michael Hecker, Madhan Thamilarasan, Dirk Koczan

et al.

International Journal of Molecular Sciences, Journal Year: 2013, Volume and Issue: 14(8), P. 16087 - 16110

Published: Aug. 5, 2013

MicroRNAs (miRNAs) are small non-coding RNA molecules acting as post-transcriptional regulators of gene expression. They involved in many biological processes, and their dysregulation is implicated various diseases, including multiple sclerosis (MS). Interferon-beta (IFN-beta) widely used a first-line immunomodulatory treatment MS patients. Here, we present the first longitudinal study on miRNA expression changes response to IFN-beta therapy. Peripheral blood mononuclear cells (PBMC) were obtained before initiation well after two days, four one month, from patients with clinically isolated syndrome (CIS) relapsing-remitting (RRMS). We measured 651 mature miRNAs about 19,000 mRNAs parallel using real-time PCR arrays Affymetrix microarrays. observed that up-regulation IFN-beta-responsive genes accompanied by down-regulation several miRNAs, members mir-29 family. These differentially expressed found be associated apoptotic processes IFN feedback loops. A network miRNA-mRNA target interactions was constructed integrating information different databases. Our results suggest miRNA-mediated regulation plays an important role mechanisms action IFN-beta, not only but also normal immune responses. levels may serve biomarker effects therapy predict individual disease activity progression.

Language: Английский

Citations

124