Molecular Neurobiology,
Journal Year:
2022,
Volume and Issue:
59(6), P. 3913 - 3932
Published: April 18, 2022
Early
life
stress
(ELS)
is
known
to
modify
trajectories
of
brain
dopaminergic
development,
but
the
mechanisms
underlying
have
not
been
determined.
ELS
perturbs
immune
system
and
microglia
reactivity,
inflammation
influence
transmission
development.
Whether
mediate
effects
on
dopamine
(DA)
development
still
unknown.
We
explored
repeated
early
social
in
male
female
mice
through
histological,
electrophysiological,
transcriptomic
analyses.
Furthermore,
we
tested
whether
these
could
be
mediated
by
ELS-induced
altered
microglia/immune
activity
a
pharmacological
approach.
found
that
DA
neurons
morphology,
reduced
transporter
(DAT)
tyrosine
hydroxylase
expression,
lowered
DAT-mediated
currents
ventral
tegmental
area
substantia
nigra
only.
Notably,
stress-induced
alterations
were
prevented
minocycline,
an
inhibitor
activation.
Transcriptome
analysis
developing
revealed
caused
downregulation
alteration
hormonal
peptide
signaling
pathways.
Results
from
this
study
offer
new
insight
into
response
maturation
after
ELS,
providing
evidence
neuroimmune
interaction,
sex
differences,
regional
specificity.
FOCUS The Journal of Lifelong Learning in Psychiatry,
Journal Year:
2025,
Volume and Issue:
23(2), P. 163 - 172
Published: April 1, 2025
Anhedonia
is
a
key
psychiatric
symptom
that
has
seen
significant
advances
in
its
understanding
both
clinical
practice
and
research
over
the
past
few
decades.
Once
considered
primarily
feature
of
depression,
recent
studies
have
shown
anhedonia
also
core
element
other
disorders
contributes
to
considerable
morbidity,
mortality,
suicidality.
Emerging
models
psychopathology
illness
emphasize
transdiagnostic
relevance
anhedonia.
At
same
time,
neuroimaging
provided
deeper
insights
into
underlying
pathophysiology,
several
assessment
scales
with
strong
psychometric
properties
been
developed.
Various
treatment
strategies-including
psychopharmacology,
neuromodulation,
psychotherapy-have
demonstrated
varying
degrees
effectiveness.
This
review
discusses
evolving
anhedonia,
significance
as
diagnostic
marker,
prevalence,
pathophysiological
underpinnings.
Additionally,
authors
provide
an
overview
tools
explore
range
approaches
studied
date.
Translational Psychiatry,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: July 16, 2021
Abstract
Anhedonia
is
a
core
symptom
of
multiple
psychiatric
disorders
and
has
been
associated
with
alterations
in
brain
structure.
Genome-wide
association
studies
suggest
that
anhedonia
heritable,
polygenic
architecture,
but
few
have
explored
the
between
genetic
loading
for
anhedonia—indexed
by
risk
scores
(PRS-anhedonia)—and
structural
imaging
phenotypes.
Here,
we
investigated
how
PRS-anhedonia
were
structure
within
UK
Biobank
cohort.
Brain
measures
(including
total
grey/white
matter
volumes,
subcortical
cortical
thickness
(CT)
white
integrity)
analysed
using
linear
mixed
models
relation
to
19,592
participants
(9225
males;
mean
age
=
62.6
years,
SD
7.44).
We
found
state
was
significantly
reduced
grey
volume
(GMV);
increased
(WMV);
smaller
volumes
thalamus
nucleus
accumbens;
CT
paracentral
cortex,
opercular
part
inferior
frontal
gyrus,
precentral
insula
rostral
anterior
cingulate
cortex;
poorer
integrity
many
tracts.
GMV;
WMV;
integrity;
parahippocampal
superior
temporal
gyrus
insula.
Overall,
both
individual
differences
structures,
including
reward-related
circuits.
These
associations
may
represent
vulnerability
markers
psychopathology
relevant
range
disorders.
Molecular Neurobiology,
Journal Year:
2022,
Volume and Issue:
59(6), P. 3913 - 3932
Published: April 18, 2022
Early
life
stress
(ELS)
is
known
to
modify
trajectories
of
brain
dopaminergic
development,
but
the
mechanisms
underlying
have
not
been
determined.
ELS
perturbs
immune
system
and
microglia
reactivity,
inflammation
influence
transmission
development.
Whether
mediate
effects
on
dopamine
(DA)
development
still
unknown.
We
explored
repeated
early
social
in
male
female
mice
through
histological,
electrophysiological,
transcriptomic
analyses.
Furthermore,
we
tested
whether
these
could
be
mediated
by
ELS-induced
altered
microglia/immune
activity
a
pharmacological
approach.
found
that
DA
neurons
morphology,
reduced
transporter
(DAT)
tyrosine
hydroxylase
expression,
lowered
DAT-mediated
currents
ventral
tegmental
area
substantia
nigra
only.
Notably,
stress-induced
alterations
were
prevented
minocycline,
an
inhibitor
activation.
Transcriptome
analysis
developing
revealed
caused
downregulation
alteration
hormonal
peptide
signaling
pathways.
Results
from
this
study
offer
new
insight
into
response
maturation
after
ELS,
providing
evidence
neuroimmune
interaction,
sex
differences,
regional
specificity.
