A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(9), P. 1734 - 1744

Published: July 8, 2024

Language: Английский

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Rough is salient: a conserved vocal niche to hijack the brain’s salience system

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2025, Volume and Issue: 380(1923)

Published: April 3, 2025

The propensity to communicate extreme emotional states and arousal through salient, non-referential vocalizations is ubiquitous among mammals beyond. Screams, whether intended warn conspecifics or deter aggressors, require a rapid increase of air influx vocal folds induce nonlinear distortions the signal. These contain temporally patterned acoustic features in restricted range audible spectrum. may have biological significance, triggering fast behavioural responses receivers. We present converging neurophysiological evidence from humans animals supporting that properties emerging phenomena are ideally adapted efficient sensory, responses. argue these temporal —rough —modulations unlikely be an epiphenomenon production but rather result selective evolutionary pressure on warning signals promote communication. In this view, rough been selected conserved as trait recruit ancestral sensory salience pathways elicit optimal reactions receiver. By exploring impact at receiver’s end, we review perceptual, neural factors shaped evolve powerful communication tools. This article part theme issue ‘Nonlinear vertebrate vocalizations: mechanisms communicative functions’.

Language: Английский

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Robust and time-resolved estimation of cardiac sympathetic and parasympathetic indices

Royal Society Open Science, Journal Year: 2025, Volume and Issue: 12(1)

Published: Jan. 1, 2025

The time-resolved analysis of heart rate (HR) and variability (HRV) is crucial for the evaluation dynamic changes autonomic activity under different clinical behavioural conditions. Standard HRV performed in frequency domain because sympathetic activations tend to increase low-frequency oscillations, while parasympathetic ones high-frequency oscillations. However, a strict separation into bands may cause biased estimations, especially range. To overcome this limitation, we propose robust estimator that combines HR dynamics, based on correlation Poincaré plot descriptors interbeat intervals from electrocardiogram. validate our method, used electrocardiograms gathered open databases where standardized paradigms were applied elicit activity. Our proposal outperforms standard spectral approach estimation low- fluctuations HRV, its performance comparable with newer methods. method constitutes valuable, robust, cost-effective tool better understanding through healthy state potentially pathological

Language: Английский

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AgRP neurons: Regulators of feeding, energy expenditure, and behavior

FEBS Journal, Journal Year: 2021, Volume and Issue: 289(8), P. 2362 - 2381

Published: Sept. 1, 2021

Neurons in the hypothalamic arcuate nucleus (ARC) that express agouti‐related peptide (AgRP) govern a critical aspect of survival: drive to eat. Equally important survival is timing at which food consumed—seeking or eating alleviate hunger face more pressing threat, like risk predation, clearly maladaptive. To ensure optimal prioritization behaviors within given environment, therefore, AgRP neurons must integrate signals internal need states with contextual environmental cues. In this state‐of‐the‐art review, we highlight recent advances extend our understanding neurons, including neural circuits they engage regulate feeding, energy expenditure, and behavior. We also discuss key findings illustrate how both classical feedback anticipatory feedforward neuronal population integration these may be disrupted excess. Finally, examine technical conceptual challenges facing field moving forward.

Language: Английский

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Interoception as modeling, allostasis as control

Biological Psychology, Journal Year: 2021, Volume and Issue: 167, P. 108242 - 108242

Published: Dec. 20, 2021

Language: Английский

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