Neuromodulation for the treatment of Prader-Willi syndrome – A systematic review

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(3), P. e00339 - e00339

Published: March 2, 2024

Prader-Willi syndrome (PWS) is a complex, genetic disorder characterized by multisystem involvement, including hyperphagia, maladaptive behaviors and endocrinological derangements. Recent developments in advanced neuroimaging have led to growing understanding of PWS as neural circuit disorder, well subsequent interests the application neuromodulatory therapies. Various non-invasive invasive device-based neuromodulation methods, vagus nerve stimulation (VNS), transcranial direct current (tDCS), repetitive magnetic (rTMS), deep brain (DBS) all been reported be potentially promising treatments for addressing major symptoms PWS. In this systematic literature review, we summarize recent that investigated these therapies, discuss underlying circuits which may underpin symptom manifestations, cover future directions field. Through our comprehensive search, there were total 47 patients who had undergone therapy Two articles described VNS, 4 tDCS, 1 rTMS 2 DBS, targeting different PWS, aberrant behavior, hyperphagia weight. Multi-center multi-country efforts will required advance field given low prevalence Finally, vulnerable population, neuroethical considerations dialogue should guide

Language: Английский

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U-shaped convolutional transformer GAN with multi-resolution consistency loss for restoring brain functional time-series and dementia diagnosis

Frontiers in Computational Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 17, 2024

The blood oxygen level-dependent (BOLD) signal derived from functional neuroimaging is commonly used in brain network analysis and dementia diagnosis. Missing the BOLD may lead to bad performance misinterpretation of findings when analyzing neurological disease. Few studies have focused on restoration time-series data.

Language: Английский

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Engrams across diseases: Different pathologies – unifying mechanisms?

Neurobiology of Learning and Memory, Journal Year: 2025, Volume and Issue: unknown, P. 108036 - 108036

Published: Feb. 1, 2025

Language: Английский

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Development and Stability of a New Brain Phantom for Leachables Screening from Deep Brain Stimulations Probes

Advanced Materials Technologies, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Implantable medical devices must meet biocompatibility requirements before clinical use, making the profiling of extractables and leachables crucial for assessing risks. Although guidelines outline methods identifying extractables, they lack guidance on monitoring leachables. This study evaluates stability a brain phantom stored at 37 °C 180 days monitoring. White matter (WM) gray (GM) components, creating an emulsion‐gel with cholesterol, agar, carboxymethylcellulose, are separated. Homogeneity is assessed using polydispersity index (PDI), investigated Young's modulus (YM), rheological behavior, apparent diffusion coefficient water (ADCs) immediately after preparation storage. PDI values 0.258 ± 0.009 WM 0.362 0.008 GM. YM 2.32 0.14 kPa 1.11 0.11 Dynamic viscosities 16.62 6.36 s 5.99 2.79 GM 0.1 rad −1 . ADCs 1130 64 µm 2 1449 34 All parameters remain within physiological range during °C. Comparison data necessary to validate this medium leachable studies.

Language: Английский

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Disentangling Bradykinesia and Rigidity in Parkinson's Disease: Evidence from Short‐ and Long‐Term Subthalamic Nucleus Deep Brain Stimulation

Annals of Neurology, Journal Year: 2024, Volume and Issue: 96(2), P. 234 - 246

Published: May 9, 2024

Objective Bradykinesia and rigidity are considered closely related motor signs in Parkinson disease (PD), but recent neurophysiological findings suggest distinct pathophysiological mechanisms. This study aims to examine compare longitudinal changes bradykinesia PD patients treated with bilateral subthalamic nucleus deep brain stimulation (STN‐DBS). Methods In this retrospective cohort study, the clinical progression of appendicular axial was assessed up 15 years after STN‐DBS best treatment conditions (ON medication ON stimulation). The severity examined using ad hoc composite scores from specific subitems Unified Parkinson's Disease Rating Scale part (UPDRS‐III). Short‐ long‐term predictors were analyzed through linear regression analysis, considering various preoperative demographic data, including duration severity, phenotype, cognitive (eg, frontal score), medication. Results A total 301 before 1 year surgery. Among them, 101 56 individuals also evaluated at 10‐year 15‐year follow‐ups, respectively. significantly worsened surgery, especially segments ( p < 0.001). Conversely, showed sustained benefit, unchanged compared assessment > 0.05). Preoperative disability UPDRS‐III) predicted short‐ outcomes for both 0.01). Executive dysfunction specifically linked not Interpretation show divergent following associated independent factors, supporting hypothesis partially pathophysiology. ANN NEUROL 2024;96:234–246

Language: Английский

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Machine learning explains response variability of deep brain stimulation on Parkinson’s disease quality of life

npj Digital Medicine, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 2, 2024

Abstract Improving health-related quality of life (QoL) is crucial for managing Parkinson’s disease. However, QoL outcomes after deep brain stimulation (DBS) the subthalamic nucleus (STN) vary considerably. Current approaches lack integration demographic, patient-reported, neuroimaging, and neurophysiological data to understand this variability. This study used explainable machine learning analyze multimodal factors affecting changes, measured by Disease Questionnaire (PDQ-39) in 63 patients, quantified each variable’s contribution. Results showed that preoperative PDQ-39 scores upper beta band activity (>20 Hz) left STN were key predictors changes. Lower initial burden predicted worsening, while improvement was associated with higher activity. Additionally, electrode positions along superior-inferior axis, especially relative z = −7 coordinate standard space, influenced outcomes, improved worsened above below marker. emphasizes a tailored, data-informed approach optimize DBS treatment improve patient QoL.

Language: Английский

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A critical role of action-related functional networks in Gilles de la Tourette syndrome

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 16, 2024

Abstract Gilles de la Tourette Syndrome (GTS) is a chronic tic disorder, characterized by unwanted motor actions and vocalizations. While brain stimulation techniques show promise in reducing severity, optimal target networks are not well-defined. Here, we leverage datasets from two independent deep (DBS) cohorts cohort of tic-inducing lesions to infer critical for treatment occurrence tics mapping sites functional connectome derived 1,000 healthy participants. We find that greater reduction linked higher connectivity DBS (N = 37) with action-related resting-state networks, i.e., the cingulo-opercular (r 0.62; p < 0.001) somato-cognitive action 0.47; 0.002). Regions network best match profiles thalamic DBS. replicate significance targeting an 10). Finally, demonstrate 22) exhibit similar these networks. Collectively, results suggest role pathophysiology GTS.

Language: Английский

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Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract The ability to measure changes in neural activities using devices implanted the brain can be useful for recording signals assess specific risk factors, monitor development of diseases, and expand understanding circuitry. Here, a neuroimplantable interface is introduced that integrates biomaterials with an advanced structural design facilitate monitoring electrophysiological responses widespread regions. uses biocompatible photopatternable materials create ultrathin, homogeneous encapsulant/substrate laminates. Comprehensive vitro tests laminin‐enveloped demonstrate efficacy relieving inflammation via biomimetic strategy by diminishing microglia astrocyte aggregation near sites, enhancing periodic signal acquisition. performance evaluated injecting acetylcholine receptor agonist into mouse brains. This approach enables real‐time changes, gain insights network dynamics assessing stimulus‐evoked signaling at identify patterns hippocampal synaptic connections. Additionally, Parkinson's disease model, deep stimulation performed are recorded confirm symptom amelioration, offering biomedical device approach. key highlights intact electrodes biocompatible, mechanically compliant conferring compact bioelectronic functionalities, high neuronal microenvironment compatibility, pathological system recognition.

Language: Английский

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Surgical Treatments of Parkinson’s Disease

Neurologic Clinics, Journal Year: 2025, Volume and Issue: 43(2), P. 383 - 397

Published: Jan. 22, 2025

Language: Английский

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Long‐Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients

Movement Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Background Subthalamic beta oscillations are a biomarker for bradykinesia and rigidity in Parkinson's disease (PD), incorporated as feedback signal adaptive deep brain stimulation with potential guiding electrode contact selection. Understanding their longitudinal stability is essential successful clinical implementation. Objectives We aimed to analyze the long‐term dynamics of peak parameters power distribution along electrodes. Methods recorded local field potentials from 12 channels per hemisphere 33 PD patients at rest, therapy‐off state two four sessions (0, 3, 12, 18–44 months) post‐surgery. analyzed bipolar (13–35 Hz) estimated monopolar subgroups consistent recordings. Results During initial 3 months, increased ( P < 0.0001). While detection high‐beta peaks was more consistent, low‐ frequencies shifted substantially some hemispheres during all periods. Spatial correlated over time. Maximal across segmented levels directions significantly stable compared chance Active contacts therapeutic showed consistently higher normalized than inactive Conclusions Our findings indicate that chronic usable beta‐guided programming. For stimulation, might be reliable Greater power, center frequency, spatial beyond an stabilization period suggests microlesional effect impacts neuronal oscillations, which should considered routine practice when using activity automated programming algorithms. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf International Parkinson Disorder Society.

Language: Английский

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