Annual Review of Neuroscience,
Journal Year:
2024,
Volume and Issue:
47(1), P. 63 - 83
Published: March 1, 2024
Deep
brain
stimulation
(DBS),
a
method
in
which
electrical
is
delivered
to
specific
areas
of
the
brain,
an
effective
treatment
for
managing
symptoms
number
neurological
and
neuropsychiatric
disorders.
Clinical
access
neural
circuits
during
DBS
provides
opportunity
study
functional
link
between
behavior.
This
review
discusses
how
use
Parkinson's
disease
dystonia
has
provided
insights
into
networks
physiological
mechanisms
that
underlie
motor
control.
In
parallel,
from
basic
science
about
patterns
impact
plasticity
communication
within
are
transforming
therapy
treating
circuits,
with
goal
training
out
its
diseased
state.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 26, 2025
Abstract
Finely
tuned
gamma
(FTG)
oscillations
from
the
subthalamic
nucleus
(STN)
and
cortex
in
Parkinson’s
disease
(PD)
patients
undergoing
deep
brain
stimulation
(DBS)
are
often
associated
with
dyskinesia.
Recently
it
was
shown
that
DBS
entrains
activity
at
1:2
of
frequency;
however,
functional
role
this
signal
is
not
yet
fully
understood.
We
recorded
local
field
potentials
STN
19
chronically
implanted
PD
on
dopaminergic
medication
during
DBS,
rest,
repetitive
movements.
Here
we
show
high-frequency
induced
entrainment
15/19
patients.
Spontaneous
FTG
present
8
patients;
five
these
dyskinesia
occurred
or
were
enhanced
entrained
stimulation.
Further,
there
a
significant
increase
power
movement
comparison
to
while
had
faster
movements
compared
those
without.
These
findings
argue
for
relevance
stimulation-induced
as
prokinetic
that,
necessarily
promoting
DBS-induced
can
be
promising
neurophysiological
biomarker
identifying
optimal
amplitude
closed-loop
DBS.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 15, 2025
Abstract
Deep
brain
stimulation
is
a
circuit
intervention
that
can
modulate
distinct
neural
pathways
for
the
alleviation
of
neurological
symptoms
in
patients
with
disorders.
In
Parkinson’s
disease,
subthalamic
deep
clinically
mimics
effect
dopaminergic
drug
treatment,
but
shared
pathway
mechanisms
on
cortex
–
basal
ganglia
networks
are
unknown.
To
address
this
critical
knowledge
gap,
we
combined
fully
invasive
multisite
recordings
undergoing
surgery
normative
MRI-based
whole-brain
connectomics.
Our
findings
demonstrate
dopamine
and
exert
mesoscale
effects
through
modulation
local
population
activity.
contrast,
at
macroscale,
its
suppression
excessive
interregional
network
synchrony
associated
indirect
hyperdirect
pathways.
results
provide
better
understanding
stimulation,
laying
foundation
advanced
closed-loop
neurostimulation
therapies.
npj Parkinson s Disease,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: April 16, 2025
Abstract
Many
drug
targets
in
ongoing
Parkinson’s
disease
(PD)
clinical
trials
have
strong
genetic
links.
While
genome-wide
association
studies
(GWAS)
nominate
regions
associated
with
disease,
pinpointing
causal
genes
is
challenging.
Our
aim
was
to
prioritize
additional
druggable
underlying
PD
GWAS
signals.
The
polygenic
priority
score
(PoPS)
integrates
information
from
MAGMA
gene-level
associations
and
over
57,000
features.
We
applied
PoPS
East
Asian
European
data
prioritized
based
on
PoPS,
distance
the
signal,
non-synonymous
credible
set
variants.
46
genes,
including
well-established
(
SNCA
,
LRRK2
GBA1
TMEM175
VPS13C
),
literature
evidence
supporting
a
mechanistic
link
RIT2,
BAG3
SCARB2,
FYN,
DYRK1A,
NOD2,
CTSB,
SV2C,
ITPKB
relatively
unexplored
PD.
hold
potential
for
repurposing
or
development.
high-confidence
links
pathogenesis
that
may
represent
our
next-best
candidates
developing
disease-modifying
therapeutics.
European Journal of Neuroscience,
Journal Year:
2025,
Volume and Issue:
61(9)
Published: May 1, 2025
ABSTRACT
Deep
brain
stimulation
(DBS)
within
the
basal
ganglia
is
a
widely
used
therapeutic
intervention
for
neurological
disorders;
however,
its
precise
mechanisms
of
action
remain
unclear.
This
study
investigates
how
DBS
may
affect
decision‐making
processes
through
computational
modeling
ganglia.
A
rate‐coded
model
incorporating
direct,
indirect,
and
hyperdirect
pathways
was
utilized
alongside
cortico‐thalamic
shortcut
known
promoting
habitual
behavior.
Simulations
two‐choice
reward
reversal
learning
task
were
conducted
to
replicate
data
from
patients
with
dystonia
in
ON
OFF
conditions.
We
demonstrate
that
plasticity
shortcut,
which
bypasses
ganglia,
crucial
reproducing
patients'
behavioral
data,
emphasizing
role
habit
formation.
Simulated
increased
behavior
following
reversal.
Integrating
different
revealed
suppression
stimulated
neurons,
efferent
axons,
combined
variant
promoted
Analyses
thalamic
inputs
showed
that,
despite
differing
effects
on
model's
activity
plasticity,
these
variants
consistently
reduced
influence
while
enhancing
shortcut.
Notably,
distinguishable
by
their
divergent
discontinued
stimulation.
These
findings
underscore
potential
multifaceted
processes.
In
particular,
our
proposes
modulates
balance
between
reward‐guided
Annual Review of Neuroscience,
Journal Year:
2024,
Volume and Issue:
47(1), P. 63 - 83
Published: March 1, 2024
Deep
brain
stimulation
(DBS),
a
method
in
which
electrical
is
delivered
to
specific
areas
of
the
brain,
an
effective
treatment
for
managing
symptoms
number
neurological
and
neuropsychiatric
disorders.
Clinical
access
neural
circuits
during
DBS
provides
opportunity
study
functional
link
between
behavior.
This
review
discusses
how
use
Parkinson's
disease
dystonia
has
provided
insights
into
networks
physiological
mechanisms
that
underlie
motor
control.
In
parallel,
from
basic
science
about
patterns
impact
plasticity
communication
within
are
transforming
therapy
treating
circuits,
with
goal
training
out
its
diseased
state.
