Severity Classification of Parkinson’s Disease via Synthesis of Energy Skeleton Images from Videos Produced in Uncontrolled Environments DOI Creative Commons
Nejib Ben Hadj-Alouane,

Arav Dhoot,

M. Turki-Hadj Alouane

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2685 - 2685

Published: Nov. 28, 2024

Parkinson's Disease is a prevalent neurodegenerative disorder affecting millions worldwide, primarily marked by motor and non-motor symptoms due to the degeneration of dopamine-producing neurons. Despite absence cure, current treatments focus on symptom management, often relying pharmacotherapy surgical interventions. Early diagnosis remains critical challenge, particularly in underserved areas, as existing diagnostic protocols lack standardization accessibility. This paper proposes novel framework for severity classification PD using video data captured uncontrolled environments.

Language: Английский

Consequences of eye movements for spatial selectivity DOI
Janis Intoy,

Yuanhao H. Li,

Norick R. Bowers

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(14), P. 3265 - 3272.e4

Published: July 1, 2024

Language: Английский

Citations

4
A Geometric Attention Mechanism to Classify Parkinsonism Smooth Pursuit Patterns DOI

L. Elisa Celis,

Juan Olmos, Fabio Martínez

et al.

Lecture notes in computer science, Journal Year: 2025, Volume and Issue: unknown, P. 99 - 109

Published: Jan. 1, 2025

Language: Английский

Citations

0
Eye Tracking in Parkinson’s Disease: A Review of Oculomotor Markers and Clinical Applications DOI Creative Commons
Pierluigi Diotaiuti, Giorgio Marotta,

Francesco Di Siena

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(4), P. 362 - 362

Published: March 31, 2025

(1) Background. Eye movement abnormalities are increasingly recognized as early biomarkers of Parkinson's disease (PD), reflecting both motor and cognitive dysfunction. Advances in eye-tracking technology provide objective, quantifiable measures saccadic impairments, fixation instability, smooth pursuit deficits, pupillary changes. These advances offer new opportunities for diagnosis, monitoring, neurorehabilitation. (2) Objective. This narrative review explores the relationship between oculomotor dysfunction PD pathophysiology, highlighting potential applications eye tracking clinical research settings. (3) Methods. A comprehensive literature was conducted, focusing on peer-reviewed studies examining PD. Relevant publications were identified through PubMed, Scopus, Web Science, using key terms, such "eye movements disease", "saccadic control neurodegeneration", "fixation instability PD", "eye-tracking assessment". Studies integrating machine learning (ML) models VR-based interventions also included. (4) Results. Patients with exhibit distinct abnormalities, including hypometric saccades, prolonged latency, increased anti-saccade errors. impairments correlate executive progression. Fixation altered responses further support role metrics non-invasive biomarkers. Emerging AI-driven show promise automated diagnosis progression tracking. (5) Conclusions. provides a reliable, cost-effective tool detection, assessment, rehabilitation. Future should focus standardizing protocols, validating predictive AI models, into multimodal treatment strategies.

Language: Английский

Citations

0
Eye movements during the Iowa Gambling Task in Parkinson’s disease: a brief report DOI Creative Commons

Kirby Doshier,

Anthony J. Ryals, Vicki A. Nejtek

et al.

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Parkinson’s disease (PD) is characterized by motor and cognitive impairments. Subtle impairment may precede impairment. There a substantial need for innovative assessments, such as those involving decision-making, to detect PD in the premotor phase. Evidence suggests executive dysfunction can impede strategic decision-making relying on learning applying feedback. The Iowa Gambling Task (IGT), when combined with eye-tracking, be valuable synergistic strategy predicting impaired therapeutic non-compliance. Participants matched healthy controls completed Movement Disorders Society’s modified Unified Disease Rating Scale (UPDRS-MDS), 6-min Walk Test (6MWT), Timed Up Go (TUG), Trail Making A B (TMT B), Controlled Oral Word Association (COWAT), Barratt Impulsiveness (BIS). Eye tracking was recorded during IGT. group scored significantly higher UPDRS subscales travelled less distance 6MWT despite equivalent performance TUG. also had longer completion times TMT more errors B. Overall IGT winning scores were marginally worse PD. However, analyzed function of over time, performed task end, thus suggesting decision-making. participants exhibited 72% reduction blinks outcomes other eye-movements. Combined established tests, inclusion eye-tracking represent powerful combination noninvasive methods monitor early progression.

Language: Английский

Citations

0
Multimodality in the Collicular Pathway: Towards Compensatory Visual Processes DOI Creative Commons
Dario Rusciano, Paola Bagnoli

Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 635 - 635

Published: April 25, 2025

The integration of multisensory inputs plays a crucial role in shaping perception and behavior, particularly the visual system. collicular pathway, encompassing optic tectum non-mammalian vertebrates superior colliculus (SC) mammals, is key hub for integrating sensory information mediating adaptive motor responses. Comparative studies across species reveal evolutionary adaptations that enhance processing contribute to compensatory mechanisms following neuronal injury. present review outlines structure function pathways, emphasizing retinocollicular projections, their integration, which depends on synaptic convergence afferents conveying from different modalities. cellular underlying multimodal remain be fully clarified, further investigations are needed clarify link between activity response stimulation behavioral involving activity. By exploring interplay fundamental neuroscience translational applications, we aim address as pivotal target its potential rehabilitation strategies.

Language: Английский

Citations

0
Noradrenergic modulation of saccades in Parkinson’s disease DOI Creative Commons
Isabella F. Orlando, Frank H. Hezemans, Rong Ye

et al.

Brain Communications, Journal Year: 2024, Volume and Issue: 6(5)

Published: Jan. 1, 2024

Noradrenaline is a powerful modulator of cognitive processes, including action decisions underlying saccadic control. Changes in eye movements are common across neurodegenerative diseases ageing, Parkinson's disease. With growing interest noradrenergic treatment potential for non-motor symptoms disease, the temporal precision oculomotor function advantageous to assess effects this modulation. Here, we studied effect 40 mg atomoxetine, noradrenaline reuptake inhibitor, 19 people with idiopathic disease using single dose, randomized double-blind, crossover, placebo-controlled design. Twenty-five healthy adult participants completed assessments provide normative data. Participants performed prosaccade and antisaccade tasks. The latency, velocity accuracy saccades, resting pupil diameter, were measured. Increased diameter on drug confirmed its expected locus coeruleus ascending arousal system. Atomoxetine altered key aspects saccade performance: latencies faster main sequence was normalized. These changes accompanied by increased error rates drug. Together, these findings suggest shift speed-accuracy trade-off visuomotor response treatment. Our results new evidence substantiate role modulation based known circuitry, advance hypothesis that reflects at level coeruleus-superior colliculus pathway. Given related conditions, system can support assessment without limb-motor confounds task performance.

Language: Английский

Citations

2
The antisaccadic paradigm: A complementary neuropsychological tool in basal ganglia disorders DOI
Lenka Hapáková, Ján Necpál, Zuzana Košutzká

et al.

Cortex, Journal Year: 2024, Volume and Issue: 178, P. 116 - 140

Published: June 22, 2024

Language: Английский

Citations

1
Eyes as a window to brain pathology in parkinson’s disease: a narrative review DOI
Marie Vidailhet

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(10), P. 1155 - 1158

Published: Aug. 24, 2024

Language: Английский

Citations

1
Modeling of Consumers' Visual Behavior by Using Artificial Intelligence DOI Creative Commons

Davoud Sadeh,

Kambiz Heidarzadeh

The Neuroscience Journal of Shefaye Khatam, Journal Year: 2024, Volume and Issue: 12(2), P. 10 - 20

Published: March 1, 2024

Language: Английский

Citations

1
Naturalistic Eye Movement Tasks in Parkinson’s Disease: A Systematic Review DOI Creative Commons

Melissa C. Gibbs,

Jenna Huxley,

Megan Rose Readman

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(7), P. 1369 - 1386

Published: Oct. 15, 2024

Eye tracking assessments in the laboratory have previously highlighted clear differences eye movements between Parkinson's disease (PD) and healthy aging. However, laboratory-based movement tasks are artificial limit ecological validity of observed results. utilizing more naturalistic scenarios may provide accurate insight into cognitive function but research this area is limited.

Language: Английский

Citations

1