An integrated transcriptomic analysis of brain aging and strategies for healthy aging DOI Creative Commons
Haiying Liu, Xin Nie, Fengwei Wang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 5, 2024

Background It is been noted that the expression levels of numerous genes undergo changes as individuals age, and aging stands a primary factor contributing to age-related diseases. Nevertheless, it remains uncertain whether there are common across organs or tissues, these play pivotal role in development Methods In this study, we screened for using RNAseq data 32 human tissues from GTEx. datasets GEO were used study drives diseases, anti-aging solutions could reverse gene expression. Results Aging transcriptome alterations showed brain differ significantly rest body, furthermore, divided into four group according their alterations. Numerous downregulated during aging, with functions enriched synaptic function, ubiquitination, mitochondrial translation autophagy. Transcriptome analysis diseases retarding hippocampus further downregulation Alzheimer’s disease but effectively reversed by high physical activity. Furthermore, neuron loss observed was Conclusion The many major contributor neurodegeneration. High activity have shown reactivate genes, making promising strategy slow aging.

Language: Английский

Innate immune sensors and regulators at the blood brain barrier: focus on toll-like receptors and inflammasomes as mediators of neuro-immune crosstalk and inflammation DOI Creative Commons
Çiğdem Acıoğlu, Stella Elkabes

Journal of Neuroinflammation, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 15, 2025

Cerebral endothelial cells (CEC) that form the brain capillaries are principal constituents of blood barrier (BBB), main active interface between and which plays a protective role by restricting infiltration pathogens, harmful substances immune into while allowing entry essential nutrients. Aberrant CEC function often leads to increased permeability BBB altering bidirectional communication bloodstream facilitating extravasation brain. In addition their as gatekeepers BBB, exhibit cell properties they can receive transmit signals partly via release inflammatory effectors in pathological conditions. express innate receptors, including toll like receptors (TLRs) inflammasomes first sensors exogenous or endogenous dangers initiators responses drive neural dysfunction degeneration. Accumulating evidence indicates activation TLRs compromises integrity, promotes aberrant neuroimmune interactions modulates both systemic neuroinflammation, common features neurodegenerative psychiatric diseases central nervous system (CNS) infections injuries. The goal present review is provide an overview pivotal roles played discuss molecular cellular mechanisms contribute disruption neuroinflammation especially context traumatic ischemic injuries infections. We will focus on most recent advances literature reports field highlight knowledge gaps. future research directions advance our understanding contribution potential at promising therapeutic targets wide variety conditions

Language: Английский

Citations

3
Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence DOI
Hao Yang, Tongyao Wang,

C.-W. Qian

et al.

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

0
Regulation of Postoperative Cognitive Dysfunction by Glutathione Under Various Pathways: A Narrative Review DOI Open Access

Yan He,

Ying Zhang, Qing Liu

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(2)

Published: Feb. 1, 2025

Postoperative cognitive dysfunction (POCD) is a common neurological complication after surgery and general anesthesia, the incidence increases with age. Will have negative impact on patients, family society. At present, neuroinflammation oxidative stress are main recognized mechanisms. Glutathione (GSH) powerful reducing agent may be related to POCD. Using medical search engines such as PubMed, Web of Science, we analyzed articles topics as: POCD, GSH, microglia, astrocyte, oligodendrocyte, ferroptosis, BDNF, Neuroinflammation, stress. The above searched in databases using Boolean operations. We included original articles, reviews other article types books. According reviewed literature, GSH treatment for Specific targeted therapies POCD still sparse, therefore, implementation preventive strategies appears remain optimal attitude. Further research needed better understanding

Language: Английский

Citations

0
Advances in the mechanistic understanding, biological consequences, and measurement of DNA adducts induced by tobacco smoke and e-cigarette aerosol: A review DOI

Xinyun Zhang,

Jiapeng Leng,

Ling Lv

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141574 - 141574

Published: Feb. 27, 2025

Language: Английский

Citations

0
Anesthetic sensitivity and resilience in the aging brain: implications for perioperative neurocognitive disorders DOI Creative Commons

Mariana Thedim,

Susana Vacas

Anesthesiology and Perioperative Science, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 3, 2025

Language: Английский

Citations

0
Research progress of cycloartane triterpenoids and pharmacological activities DOI Open Access
Chen Wang, Xiaodong Mu, Jingyong Sun

et al.

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Cycloartane triterpenoids are widely distributed in the plant kingdom, and there have been reports of hundreds families containing cycloartane triterpenoids. But types content different among various plants. In recent years, a large amount extracted studied from plants, some exhibit great pharmacological activities terms antiaging, antioxidant, anti‐inflammatory, anticancer, antiarrhythmic effects, so on. Herein, we systematically reviewed these research on structure naturally occurring, synthetic, semisynthetic triterpenoids, with particular emphasis their activities.

Language: Английский

Citations

0
Intermittent fasting attenuates CNS inflammaging - rebalancing the transposonome DOI Creative Commons
Mitchell J Cummins, Ethan T Cresswell, Doug W. Smith

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Abstract A hallmark of CNS aging is sterile, chronic, low-grade neuroinflammation. Understanding how the develops chronic inflammation necessary to achieve extended healthspan. Characterisation neuroinflammatory molecular triggers remains limited. Interventions that reduce neuroinflammation and extend health lifespan could be useful in this regard. One such intervention intermittent fasting (IF), but IF impacts insufficiently understood. To address this, we performed deep RNA-sequencing on young, middle-aged, old, mouse regions. Additionally, sequenced spinal cord animals subject adult lifelong IF. We found most differentially expressed genes (DEGs) at middle age were region specific (~ 50–84%), whilst effect weakened 18–72%) old age, suggesting emergence a more general global profile. DEGs from all regions enriched for inflammatory immune ontologies. Surprisingly, SC was aging- neuroinflammation-impacted both ages, with by far highest number DEGs, largest net increase expression transposable elements (TEs), greatest enrichment immune-related ontologies, generally larger increases gene expression. Overall, normal upregulation sensors non-self, DNA/RNA, activation inflammasomes, cGAS-STING1 interferon response genes, across CNS. Whilst still developed an profile SC, average lower ~ 50% compared age-matched controls. IF-specific apparent, also acts separate, potentially targetable, pathways those impacted aging. Expression disease associated microglia, phagocytic exhaustion, STING1, inflammasome decreased Significantly, TE reversed decrease. In summary, find hotspot, attenuates neuroinflammaging rebalancing transposonome.

Language: Английский

Citations

0
Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis DOI Creative Commons

Shafie Fazel,

Massimo Carollo, Lisanne Tap

et al.

Drugs & Aging, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Cognitive impairment poses significant challenges for aging populations. Systemic inflammation, a hallmark of rheumatoid arthritis (RA), has been implicated in neurodegeneration through mechanisms including blood–brain barrier disruption, microglial activation, and cytokine-mediated neuronal damage. This review examines the potential impact disease-modifying antirheumatic drugs (DMARDs) on cognitive function RA, focusing inflammatory pathways linking systemic inflammation to neuroinflammation decline. DMARDs, categorized into conventional synthetic (csDMARDs), biologic (bDMARDs), targeted (tsDMARDs) classes, modulate immune responses distinct mechanisms. Evidence suggests that particularly bDMARDs targeting proinflammatory cytokines such as TNF-α IL-6, may mitigate neuroinflammatory processes preserve function. However, csDMARDs methotrexate is complex, with conflicting reports regarding its role vascular dementia. Emerging therapies Janus kinase inhibitors (JAK-i) offer promise modulating central though clinical evidence remains limited. While some studies highlight protective effects DMARDs against dementia, findings are inconsistent, hindered by heterogeneity study design, patient demographics, assessment methods. underscores need personalized treatment strategies, integrating RA management health considerations. Future research should prioritize robust, prospective long-term follow-up, incorporating neuroimaging biomarker analysis elucidate underpinning DMARD-associated outcomes. A better understanding involved could lead improved therapeutic approaches, enhancing quality life patients potentially benefiting broader strategies preventing or treating

Language: Английский

Citations

0
Cell-based regenerative and rejuvenation strategies for treating neurodegenerative diseases DOI Creative Commons
Siyuan Deng, Huangfan Xie, Bingqing Xie

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 6, 2025

Neurodegenerative diseases including Alzheimer's and Parkinson's disease are age-related disorders which severely impact quality of life impose significant societal burdens. Cellular senescence is a critical factor in these disorders, contributing to their onset progression by promoting permanent cell cycle arrest reducing cellular function, affecting various types cells brain. Recent advancements regenerative medicine have highlighted "R3" strategies-rejuvenation, regeneration, replacement-as promising therapeutic approaches for neurodegeneration. This review aims critically analyze the role neurodegenerative organizes within R3 paradigm. Specifically, we examine stem therapy, direct lineage reprogramming, partial reprogramming context R3, emphasizing how interventions mitigate counteracting aging-related Ultimately, this seeks provide insights into complex interplay between neurodegeneration while highlighting promise cell-based strategies address debilitating conditions.

Language: Английский

Citations

0
Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects DOI Creative Commons

Yingshuo Bei,

Ting Wang, Shuwen Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 450 - 450

Published: April 9, 2025

Aging is a process of gradual functional decline in complex physiological systems and closely related to the occurrence various diseases. Berberine, bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as promising candidate for anti-aging interventions. This study comprehensively investigated lifespan-extending effects molecular mechanisms berberine C. elegans through integrated approaches including lifespan assays, locomotor activity analysis, oxidative stress challenges, transcriptomic profiling. Furthermore, genetic models mutant transgenic worms were employed delineate their interactions with insulin/IGF-1 signaling (IIS) pathway. Our results demonstrate that extended mean wild-type by 27%. By activating transcription factors such DAF-16/FOXO, HSF-1, SKN-1/NRF2, upregulated antioxidant enzyme expression, reduced lipofuscin accumulation, improved resistance. Transcriptomic analysis revealed significant changes lipid metabolism-related genes, particularly pathways involving fatty acid synthesis, degradation, sphingolipid metabolism. These findings establish exerts multi-target coordinated activation stress-responsive metabolic optimization, providing mechanistic insights developing natural product-based geroprotective strategies.

Language: Английский

Citations

0