An integrated transcriptomic analysis of brain aging and strategies for healthy aging DOI Creative Commons
Haiying Liu, Xin Nie, Fengwei Wang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 5, 2024

Background It is been noted that the expression levels of numerous genes undergo changes as individuals age, and aging stands a primary factor contributing to age-related diseases. Nevertheless, it remains uncertain whether there are common across organs or tissues, these play pivotal role in development Methods In this study, we screened for using RNAseq data 32 human tissues from GTEx. datasets GEO were used study drives diseases, anti-aging solutions could reverse gene expression. Results Aging transcriptome alterations showed brain differ significantly rest body, furthermore, divided into four group according their alterations. Numerous downregulated during aging, with functions enriched synaptic function, ubiquitination, mitochondrial translation autophagy. Transcriptome analysis diseases retarding hippocampus further downregulation Alzheimer’s disease but effectively reversed by high physical activity. Furthermore, neuron loss observed was Conclusion The many major contributor neurodegeneration. High activity have shown reactivate genes, making promising strategy slow aging.

Language: Английский

An integrated transcriptomic analysis of brain aging and strategies for healthy aging DOI Creative Commons
Haiying Liu, Xin Nie, Fengwei Wang

et al.

Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16

Published: Dec. 5, 2024

Background It is been noted that the expression levels of numerous genes undergo changes as individuals age, and aging stands a primary factor contributing to age-related diseases. Nevertheless, it remains uncertain whether there are common across organs or tissues, these play pivotal role in development Methods In this study, we screened for using RNAseq data 32 human tissues from GTEx. datasets GEO were used study drives diseases, anti-aging solutions could reverse gene expression. Results Aging transcriptome alterations showed brain differ significantly rest body, furthermore, divided into four group according their alterations. Numerous downregulated during aging, with functions enriched synaptic function, ubiquitination, mitochondrial translation autophagy. Transcriptome analysis diseases retarding hippocampus further downregulation Alzheimer’s disease but effectively reversed by high physical activity. Furthermore, neuron loss observed was Conclusion The many major contributor neurodegeneration. High activity have shown reactivate genes, making promising strategy slow aging.

Language: Английский

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