Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development DOI Open Access
Sarmin Ummey Habiba,

Ho Jin Choi,

Yeasmin Akter Munni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12701 - 12701

Published: Nov. 26, 2024

Foeniculum vulgare Mill, commonly known as fennel, is an aromatic herb traditionally used for culinary and medicinal purposes, with potential therapeutic effects on neurological disorders. However, limited research has focused its neurotrophic impact, particularly neuronal maturation synaptic development. This study investigates the of F. ethanol extracts (FVSE) rat primary hippocampal neurons. Results show that FVSE prominent component, anethole, significantly promote neurite outgrowth in a dose-dependent manner. Optimal axonal dendritic growth occurred at concentrations 40 µg/mL 20 µM respectively, without causing cytotoxicity, underscoring safety health. Additionally, enhances formation synapses, essential communication. Network pharmacology analysis revealed components influence critical pathways, including PI3K-AKT Alzheimer’s disease pathways. Specifically, modulates key proteins, tropomyosin receptor kinase (Trk), glycogen synthase 3 (GSK3βser9), phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated protein (Erk1/2). Anethole was found to play role regulating these which confirmed by immunocytochemistry experiments demonstrating effect promoting In conclusion, this highlights properties FVSE, anethole emerging bioactive compound. These findings provide valuable insights into fennel treating disorders, offering basis future interventions survival.

Language: Английский

Deciphering the genetic underpinnings of neuroticism: A Mendelian randomization study of druggable gene targets DOI
Yanggang Hong, Yi Wang,

Wanyi Shu

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 370, P. 147 - 158

Published: Nov. 2, 2024

Language: Английский

Citations

6
APOE4 exacerbates glucocorticoid stress hormone-induced tau pathology via mitochondrial dysfunction DOI Creative Commons
Qing Yu, Fang Du, Jeffrey H. Goodman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract APOE4 is the leading genetic risk factor for Alzheimer’s disease, and chronic stress a environmental factor. Studies suggest that confers vulnerability to behavioral neuropathological effects of stress, representing potential mechanism by which this variant accelerates onset progression. Whether how -mediated manifests in neurons hippocampus, brain region particularly susceptible pathology, remains unexplored. Using combination vivo vitro experiments humanized APOE3 knockin mice primary hippocampal from these animals, we investigate whether sensitivity glucocorticoids, main hormones. We find major hallmark stress/glucocorticoid-induced damage, tau pathology (i.e., accumulation, hyperphosphorylation, spreading) exacerbated versus mice. Moreover, animals exhibit underlying mitochondrial dysfunction enhanced glucocorticoid receptor activation factors likely contribute pathogenesis both presence absence stress/glucocorticoids. Supporting concept, show opening permeability transition pore drives mice, pharmacological inhibition protective against ApoE4-mediated phosphorylation spreading, downstream synapse loss. These findings shed light on mechanisms carriers identify as therapeutic target ameliorating population.

Language: Английский

Citations

0
Impact of corticoid receptors on Alzheimer’s disease: a neuroendocrine perspective DOI
Falguni Goel,

Daksh Kumar,

Anushka Sharma

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

Citations

0
Dexmedetomidine Reduces Chronic Stress–Related Thrombosis in a Mouse FeCl3 Model DOI Creative Commons
Huazhen Wang, Meiping Zhang,

Minglong Xin

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(9)

Published: April 30, 2025

ABSTRACT Chronic psychological stress (CPS) is a significant risk factor for thrombotic cardio‐cerebrovascular diseases (TCVDs). Clinical data suggest that the α 2 ‐adrenergic receptor (AdR‐α ) agonist dexmedetomidine (Dex) can influence coagulation in stress‐exposed intensive care unit patients. Given important role of protease‐activated receptor‐2 (PAR‐2) vascular pathobiology, we aimed to investigate potential effects Dex on stress‐related thrombus formation, focusing PAR‐2 signaling pathway. Eight‐week‐old male mice underwent non‐stress and immobilization with treatment weeks were then subjected carotid artery thrombosis induction using ferric chloride (FeCl 3 ). On Day 14 post‐stress, exhibited increased weight length, along harmful alterations plasma levels von Willebrand metalloproteinase thrombospondin Type 13 motifs. Additionally, arterial protein and/or mRNA PAR‐2, p‐Akt, Bcl‐2, cleaved caspase‐3, cytochrome c , gp91 phox TNF‐α, MCP‐1, ICAM‐1, VCAM‐1, TLR‐4 altered, accompanied by endothelial loss. reversed these changes. Conversely, AdR‐α2 blockage yohimbine diminished benefits Dex. In vitro, reduced serum‐induced reactive oxygen species production apoptosis, beneficial levels. Yohimbine effects. Thus, activation appeared mitigate formation undergoing FeCl ‐induced surgery, possibly negatively regulating signaling. These findings therapeutic strategy CPS‐related events patients TCVDs.

Language: Английский

Citations

0
How can early stress influence later Alzheimer risk? Possible mediators and underlying mechanisms. DOI Creative Commons
Paul J. Lucassen, Anikó Kőrösi, Susanne R. de Rooij

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

1
Hippocampal Synaptic Plasticity: Integrating Memory and Anxiety Impairments in the Early Stages of Alzheimer’s Disease DOI
Mark Good, David M. Bannerman

Current topics in behavioral neurosciences, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Ketamine reverses chronic stress-induced behavioral changes via the expression of Ca2+-permeable AMPA receptors in mice DOI Open Access

Joshua C. Flowers,

Paige E. Vetter,

McKennon J Wiles

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 7, 2024

Abstract Background and Purpose Chronic stress affects brain functions leading to the development of mental disorders like anxiety depression, as well cognitive decline social dysfunction. Among many biological changes in chronically stressed brains, disruptions AMPA Receptor (AMPAR)-mediated synaptic transmission hippocampus are associated with responses. We have revealed that low-dose ketamine rapidly induces expression GluA1-containing, GluA2-lacking Ca 2+ -Permeable AMPARs (CP-AMPARs), which enhances glutamatergic strength hippocampal neurons. Additionally, subanesthetic decreases anxiety– depression-like behaviors naïve animals. In addition reducing some research indicates may protective effects against chronic both humans However, role CP-AMPARs actions ketamine’s antistress is largely unknown. Experimental Approach use whole-cell patch-clamp recordings from CA1 pyramidal neurons female male slices multiple behavioral assays including reciprocal interaction, contextual fear conditioning, tail suspension test. Key Results demonstrate treatment reverses restraint (CRS)-induced dysfunction, hippocampus-dependent memory loss, behavior mice. Furthermore, we show ketamine-induced on these dependent CP-AMPAR expression. Conclusion Implications Our findings suggest triggers hippocampus, antidepressant effects.

Language: Английский

Citations

0
Neurotrophic Effects of Foeniculum vulgare Ethanol Extracts on Hippocampal Neurons: Role of Anethole in Neurite Outgrowth and Synaptic Development DOI Open Access
Sarmin Ummey Habiba,

Ho Jin Choi,

Yeasmin Akter Munni

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12701 - 12701

Published: Nov. 26, 2024

Foeniculum vulgare Mill, commonly known as fennel, is an aromatic herb traditionally used for culinary and medicinal purposes, with potential therapeutic effects on neurological disorders. However, limited research has focused its neurotrophic impact, particularly neuronal maturation synaptic development. This study investigates the of F. ethanol extracts (FVSE) rat primary hippocampal neurons. Results show that FVSE prominent component, anethole, significantly promote neurite outgrowth in a dose-dependent manner. Optimal axonal dendritic growth occurred at concentrations 40 µg/mL 20 µM respectively, without causing cytotoxicity, underscoring safety health. Additionally, enhances formation synapses, essential communication. Network pharmacology analysis revealed components influence critical pathways, including PI3K-AKT Alzheimer’s disease pathways. Specifically, modulates key proteins, tropomyosin receptor kinase (Trk), glycogen synthase 3 (GSK3βser9), phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated protein (Erk1/2). Anethole was found to play role regulating these which confirmed by immunocytochemistry experiments demonstrating effect promoting In conclusion, this highlights properties FVSE, anethole emerging bioactive compound. These findings provide valuable insights into fennel treating disorders, offering basis future interventions survival.

Language: Английский

Citations

0