Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons DOI Creative Commons
Frank Raven, Alexis Vega-Medina,

Kailynn Schmidt

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Study objectives Brief sleep loss alters cognition and synaptic structures of principal neurons in hippocampus neocortex. However, while vivo recording bioinformatic data suggest that inhibitory interneurons are more strongly affected by loss, it is unclear how deprivation affect interneurons’ synapses. Disruption the SST+ interneuron population seems to be a critical early sign neuropathology Alzheimer’s dementia, schizophrenia, bipolar disorder - risk developing all three increased habitual loss. We aimed test various brain regions brief disruption. Methods used Brainbow 3.0 label dorsal hippocampus, prefrontal cortex, visual cortex male SST-CRE transgenic mice, then compared labeled after 6-h period ad lib sleep, or gentle handling (SD) starting at lights on. Results Dendritic spine density among both neocortex was altered subregion-specific manner, with overall thin CA1, dramatic increases volume surface area CA3, small but significant changes (primarily decreases) size PFC V1. Conclusions Our connectivity significantly region-specific manner few hours This suggests cell type-specific mechanism which disrupts excitatory-inhibitory balance networks. Significance Statement Changes function somatostatin-expressing (SST+) have been implicated etiology psychiatric neurological disorders behavior affected. Here, we measure effects very experimental on neocortex, for sleep-dependent memory processing. find only six restructures dendritic spines, causing widespread size. These potential dramatically alter across these networks, leading cognitive disruptions commonly associated

Language: Английский

Somatostatin neurons detect stimulus-reward contingencies to reduce neocortical inhibition during learning DOI
Eunsol Park, Dika Kuljis,

Rachel A Swindell

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115606 - 115606

Published: April 20, 2025

Language: Английский

Citations

0
Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons DOI Creative Commons
Frank Raven, Alexis Vega-Medina,

Kailynn Schmidt

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Study objectives Brief sleep loss alters cognition and synaptic structures of principal neurons in hippocampus neocortex. However, while vivo recording bioinformatic data suggest that inhibitory interneurons are more strongly affected by loss, it is unclear how deprivation affect interneurons’ synapses. Disruption the SST+ interneuron population seems to be a critical early sign neuropathology Alzheimer’s dementia, schizophrenia, bipolar disorder - risk developing all three increased habitual loss. We aimed test various brain regions brief disruption. Methods used Brainbow 3.0 label dorsal hippocampus, prefrontal cortex, visual cortex male SST-CRE transgenic mice, then compared labeled after 6-h period ad lib sleep, or gentle handling (SD) starting at lights on. Results Dendritic spine density among both neocortex was altered subregion-specific manner, with overall thin CA1, dramatic increases volume surface area CA3, small but significant changes (primarily decreases) size PFC V1. Conclusions Our connectivity significantly region-specific manner few hours This suggests cell type-specific mechanism which disrupts excitatory-inhibitory balance networks. Significance Statement Changes function somatostatin-expressing (SST+) have been implicated etiology psychiatric neurological disorders behavior affected. Here, we measure effects very experimental on neocortex, for sleep-dependent memory processing. find only six restructures dendritic spines, causing widespread size. These potential dramatically alter across these networks, leading cognitive disruptions commonly associated

Language: Английский

Citations

1