HMGB2-induced calreticulin translocation required for immunogenic cell death and ferroptosis of cancer cells are controlled by the nuclear exporter XPO1

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 1, 2024

Language: Английский

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Ferrostatin-1 mitigates cellular damage in a ferroptosis-like environment in Caenorhabditis elegans

Toxicological Sciences, Journal Year: 2024, Volume and Issue: 200(2), P. 357 - 368

Published: May 15, 2024

Although iron (Fe) is the most biologically abundant transition metal, it highly toxic when accumulates as Fe2+, forming a labile Fe pool and favoring Fenton reaction. This oxidative scenario leads to type of caspase-independent programmed cell death, referred ferroptosis, where following processes take place: (i) Fe2+ overload, (ii) glutathione peroxidase 4 inactivation, (iii) lipid peroxidation, (iv) depletion. The present study sought evaluate consequences administration on ferroptosis induction in Caenorhabditis elegans. We demonstrated higher mortality, increased reduced activity, morphological damage dopaminergic neurons upon overload. Pharmacological intervention at level peroxidation with ferrostatin-1 (250 μM) mitigated returned biochemical parameters basal levels, revealing potential this therapeutical approach. Finally, assess relationship between dopamine Parkinsonian background, we evaluated UA44 worm strain which overexpresses alpha-synuclein protein cherry-labeled neurons. that lethality associated similar alterations wild-type animals. These experiments provide mechanistic-based evidence efficacy pharmacological approach mitigate physiological, biochemical, At same time, they encourage further research impact combined effects resulting from genetic background signaling phenotype.

Language: Английский

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Ferroptosis in Neurons: A Bibliometric Analysis of Research Trends, Key Contributions, and Emerging Directions

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Background Neurons are the fundamental structural and functional units of nervous system, serving as core cells for information transmission regulation. They closely associated with various neurological diseases. Recent studies have shown significant advancements in research on ferroptosis neurons; however, there has been a lack bibliometric analysis this field. This study aims to provide comprehensive overview knowledge structure related neurons through methods, identify current trends hotspots, predict potential future directions. Methods We conducted search publications from 2014 2024 Web Science Core Collection (WoSCC) database. Bibliometric methods were employed analyze authors, institutions, countries, journals, references using VOSviewer, CiteSpace, R package "bibliometrix". Results included 685 articles 50 China United States being leading contributors. The number year-on-year increase. primary institutions Central South University, Harbin Medical University Melbourne. Free Radical Biology Medicine is most popular journal field, while Cell highest citation count. A total 4,673 authors contributed research, David Devos Ashley I. Bush having publications, Scott J. Dixon had co-citations. Keyword revealed that molecular mechanisms its application diseases focuses Conclusion first summarizing developments neurons. outlines predicts global hotspots trends, providing valuable scholars studying ferroptosis.

Language: Английский

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Synthesis and Bio-evaluation of Aminoferrocene-Based Anticancer Prodrugs as Potent Ferroptosis Inducers

Inorganic Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Novel ROS-responsive N -alkylaminoferrocene (NAAF)-appended GPX4 inhibitors have been designed and prepared as potent ferroptosis-inducing prodrugs.

Language: Английский

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Arginine tagged liposomal carrier for the delivery of celastrol for ferroptosis-induced hepatocellular carcinoma therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 250, P. 114546 - 114546

Published: Feb. 3, 2025

Language: Английский

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