Yinling Qushi Granule as a therapeutic agent for metabolic syndrome: pharmacological, molecular targets, and pharmacokinetic insights DOI Creative Commons
Linlin Jin,

Shaoqin Lin,

He Yan

et al.

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(2)

Published: May 30, 2025

Abstract Metabolic Syndrome (MetS) is a globally prevalent condition with unclear underlying mechanisms. Current treatments primarily focus on alleviating individual symptoms, lacking long-term therapeutic strategies that target the disease’s endotypes. In this study, we found Yinling Qushi Granule (YLQSG), formulated prescription for treating Dampness (DS) in Traditional Chinese Medicine (TCM), effectively attenuated hypertension associated MetS. After 12 weeks of YLQSG treatment, MetS patients showed significant reduction systolic and diastolic blood pressure, body mass index (BMI) glycated hemoglobin (HbA1c). Chemical analysis has identified total 96 components YLQSG, alongside 27 serum absorbed prototypes 13 metabolites. vivo metabolic profiling revealed critical Phase I metabolism including dehydration, demethylation, oxidation. By integrating network pharmacology molecular docking, proposed 11 triterpenoids from sovereign herb Poria cocos (Schw.) Wolf as active constituents YLQSG. These potent binding affinities AGTR1 11β-HSD1, two crucial druggable targets renin–angiotensin–aldosterone system. Pharmacokinetics these lanosterol-type rat indicated their good drug likeness properties. summary, our findings highlight potential MetS, particularly hypertension, identify its compounds targets, offering promising alternative strategy management Trial registration ChiCTR, ChiCTR2200063506. Registered 9 September 2022, https://www.chictr.org.cn/showproj.html?proj=174653 .

Language: Английский

One Novel Nortriterpenoid from the Mastic (<i>Pistacia lentiscus</i>) and Its Anti-Inflammatory Activity DOI Open Access
Yue Wu,

Xuerui An,

Haofan Lv

et al.

Phyton, Journal Year: 2025, Volume and Issue: 0(0), P. 1 - 10

Published: Jan. 1, 2025

A novel pair of oleanane nor-triterpenes, with compound 1 featuring a unique 18α-H structure, was isolated from mastic, and this represents noteworthy new entity not previously reported in the literature.The absolute configurations their structures were further determined using combination different analytical methods such as NMR, high-resolution mass spectrometry (HR-MS), ultraviolet (UV), infrared (IR) single-crystal X-ray diffraction (SXRD).The actively mitigated inflammations by efficiently quenching nitric oxide (NO) synthesis within an ex vivo system lipopolysaccharide activated murine macrophage RAW264.7 cells.Moreover, exhibit better IC 50 concentration 11.69 ± 1.39 µM, surpassing efficacy positive control dexamethasone, which exhibited 23.21 1.17 μM.While 2 also demonstrated inhibitory activity, its potency comparatively weaker, 26.18 2.66 μM.

Language: Английский

Citations

0
Salicylic acid-induced upregulation of AtAACT and AtMVD expression enhances triterpene biosynthesis in Athelia termitophila DOI
Fangcheng Hu,

Y. Fang,

Lianxi Xing

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(3)

Published: Feb. 27, 2025

Language: Английский

Citations

0
Biosynthesis of triterpenoids in plants: Pathways, regulation, and biological functions DOI
Huan Dong, Xiaoquan Qi

Current Opinion in Plant Biology, Journal Year: 2025, Volume and Issue: 85, P. 102701 - 102701

Published: March 20, 2025

Language: Английский

Citations

0
A Direct Relationship Between ‘Blood Stasis’ and Fibrinaloid Microclots in Chronic, Inflammatory, and Vascular Diseases, and Some Traditional Natural Products Approaches to Treatment DOI Creative Commons
Douglas B. Kell, Etheresia Pretorius, Huihui Zhao

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(5), P. 712 - 712

Published: May 12, 2025

'Blood stasis' (syndrome) (BSS) is a fundamental concept in Traditional Chinese Medicine (TCM), where it known as Xue Yu (). Similar concepts exist Korean ('Eohyul') and Japanese Kampo medicine (Oketsu). Blood stasis considered to underpin large variety of inflammatory diseases, though an exact equivalent Western systems yet be described. Some time ago we discovered that blood can clot into anomalous amyloid form, creating what have referred fibrinaloid microclots. These microclots occur great many chronic, diseases are comparatively resistant fibrinolysis, thus the ability block microcapillaries hence lower oxygen transfer tissues, with multiple pathological consequences. We here develop idea precisely relate to, largely mechanistically responsible for, traditional (a term also used by Virchow). First, associated all stasis. Secondly, blocking red cell transport, provide simple mechanistic explanation for physical slowing down ('stasis') flow. Thirdly, herbal formulae proposed treat these especially Fu Zhu its derivatives, anticoagulatory anti-inflammatory, consistent they actually helping levels microclots, plausibly part catalysis polymerization fibrinogen form. rehearse some actions constituent herbs specific bioactive molecules contain. Consequently, such formulations (and their components), which little science medicine, would seem offer opportunity novel, safe, useful treatments chronic display including Myalgic Encephalopathy/Chronic Fatigue Syndrome, long COVID, even ischemic stroke.

Language: Английский

Citations

0
Malbrumpenoids A-N, unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16 DOI
Shuqi Wu, Xinying Zhu, Fang-Yu Yuan

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111336 - 111336

Published: May 1, 2025

Language: Английский

Citations

0
Yinling Qushi Granule as a therapeutic agent for metabolic syndrome: pharmacological, molecular targets, and pharmacokinetic insights DOI Creative Commons
Linlin Jin,

Shaoqin Lin,

He Yan

et al.

Advanced Biotechnology, Journal Year: 2025, Volume and Issue: 3(2)

Published: May 30, 2025

Abstract Metabolic Syndrome (MetS) is a globally prevalent condition with unclear underlying mechanisms. Current treatments primarily focus on alleviating individual symptoms, lacking long-term therapeutic strategies that target the disease’s endotypes. In this study, we found Yinling Qushi Granule (YLQSG), formulated prescription for treating Dampness (DS) in Traditional Chinese Medicine (TCM), effectively attenuated hypertension associated MetS. After 12 weeks of YLQSG treatment, MetS patients showed significant reduction systolic and diastolic blood pressure, body mass index (BMI) glycated hemoglobin (HbA1c). Chemical analysis has identified total 96 components YLQSG, alongside 27 serum absorbed prototypes 13 metabolites. vivo metabolic profiling revealed critical Phase I metabolism including dehydration, demethylation, oxidation. By integrating network pharmacology molecular docking, proposed 11 triterpenoids from sovereign herb Poria cocos (Schw.) Wolf as active constituents YLQSG. These potent binding affinities AGTR1 11β-HSD1, two crucial druggable targets renin–angiotensin–aldosterone system. Pharmacokinetics these lanosterol-type rat indicated their good drug likeness properties. summary, our findings highlight potential MetS, particularly hypertension, identify its compounds targets, offering promising alternative strategy management Trial registration ChiCTR, ChiCTR2200063506. Registered 9 September 2022, https://www.chictr.org.cn/showproj.html?proj=174653 .

Language: Английский

Citations

0