The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 195 - 195
Published: Feb. 14, 2025
Most
brain
development
occurs
in
the
"first
1000
days",
a
critical
period
from
conception
to
child's
second
birthday.
Critical
processes
that
occur
during
this
time
include
synaptogenesis,
myelination,
neural
pruning,
and
formation
of
functioning
neuronal
circuits.
Perturbations
first
days
likely
contribute
later-life
neurodegenerative
disease,
including
sporadic
amyotrophic
lateral
sclerosis
(ALS).
Neurodevelopment
is
determined
by
many
events,
maturation
colonization
infant
microbiome
its
metabolites,
specifically
neurotransmitters,
immune
modulators,
vitamins,
short-chain
fatty
acids.
Successful
gut-brain
axis
function
depend
on
maternal
factors
(stress
exposure
toxins
pregnancy),
mode
delivery,
quality
postnatal
environment,
diet
after
weaning
breast
milk,
nutritional
deficiencies.
While
neonatal
highly
plastic,
it
remains
prone
dysbiosis
which,
once
established,
may
persist
into
adulthood,
thereby
inducing
chronic
inflammation
abnormal
excitatory/inhibitory
balance,
resulting
excitation.
Both
are
recognized
as
key
pathophysiological
ALS.
Language: Английский
Gut microbiota in colorectal cancer: a review of its influence on tumor immune surveillance and therapeutic response
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
15
Published: March 5, 2025
Colorectal
cancer
(CRC)
poses
a
significant
global
health
burden,
with
gut
microbiota
emerging
as
crucial
modulator
of
CRC
pathogenesis
and
therapeutic
outcomes.
This
review
synthesizes
current
evidence
on
the
influence
tumor
immune
surveillance
responses
to
immunotherapies
chemotherapy
in
CRC.
We
highlight
role
specific
microbial
taxa
promoting
or
inhibiting
growth
potential
microbiota-based
biomarkers
for
predicting
treatment
efficacy.
The
also
discusses
implications
modulation
strategies,
including
diet,
probiotics,
fecal
transplantation,
personalized
management.
By
critically
evaluating
literature,
we
aim
provide
comprehensive
understanding
microbiota’s
dual
inform
future
research
directions
this
field.
Language: Английский