Bibliometric analysis of metformin as an immunomodulator (2013–2024)

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 8, 2025

Metformin, the frontline treatment for diabetes, has considerable potential as an immunomodulator; however, detailed bibliometric analyses on this subject are limited. This study extracted 640 relevant articles from Web of Science (WOS) Core Collection and conducted visual using Microsoft Excel, VOSviewer, CiteSpace. The findings showed that research immunomodulatory function metformin grown steadily since 2017, with China United States being leading contributors. These studies have mostly been published in journals such International Journal Molecular Sciences, Cancers, Frontiers Immunology, Scientific Reports. Keyword co-occurrence analysis highlighted metformin's role immunomodulator, particularly context tumor immune microenvironment, immunosuppressive checkpoints, derivatives. Recent application aging, autoimmune diseases, COVID-19, tuberculosis. Additionally, its regulating inflammation gut microbiota is also investigated. Overall, effects were investigated anti-tumor, antiviral, anti-aging, disease research. highlights scope use these fields, while significantly enhancing clinical value a repurposed drug.

Language: Английский

Exploring the Immunological Aspects and Treatments of Recurrent Pregnancy Loss and Recurrent Implantation Failure

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1295 - 1295

Published: Feb. 3, 2025

Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more consecutive losses before 24 weeks gestation. It affects 3-5% women who are attempting to conceive. RPL can stem from a variety causes and frequently associated with psychological distress diminished quality life. By contrast, recurrent implantation failure (RIF) refers inability achieve successful after three high-quality embryo transfers at least instances egg donation. RIF shares several causative factors RPL. The immunological underpinnings these conditions involve alterations in uterine NK cells, reductions M2 macrophages myeloid-derived suppressor an increased Th1/Th2 ratio, decreased Treg/Th17 presence shared ≥3 HLA alleles between partners, autoimmune disorders. Various therapeutic approaches have been employed address concerns, achieving varying degrees success, although some therapies remain contentious within medical community. This review intends explore implicated analyze treatments for conditions, which may include steroids, intravenous immunoglobulins, calcineurin inhibitors, anti-TNF antibodies, intralipid infusions, granulocyte colony-stimulating factor, lymphocyte immunotherapy.

Language: Английский

Therapeutic potential of isoniazid carbohydrazide derivatives as a promising anti-inflammatory and anti-diabetic drug via synthesis, characterization, biological screening, and computational studies

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141106 - 141106

Published: Dec. 1, 2024

Language: Английский