Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver DOI Creative Commons
Merve Çebi, Yusuf Yılmaz

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

In recent years, the prevalence of chronic liver diseases, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), has increased significantly. This upward trend is largely associated with lifestyle-related factors such as unhealthy dietary habits, physical inactivity, and various environmental influences. Among key elements contributing to pathogenesis MASLD, integrity intestinal epithelial barrier emerges a critical determinant, given its central role in maintaining immune homeostasis along gut-liver axis. Disruption this barrier, often driven by excessive consumption saturated fats refined carbohydrates combination low fiber intake, can lead microbial dysbiosis. imbalance gut microbiota triggers dysregulation promotes systemic inflammation, thereby exacerbating hepatic injury. review discusses contribution dysfunction development progression particular focus on how permeability may initiate sustain inflammation. Additionally, influence integrity, responses, inflammatory cascade addressed. A better understanding complex interplay between impairment, modulation, pathology offer valuable insights into MASLD pathophysiology contribute more targeted therapeutic strategies.

Language: Английский

Omega-3 Polyunsaturated Fatty Acids: A Clinical Perspective on Gut Microbiota, Major Depressive Disorder, and Obesity DOI
Jane Pei‐Chen Chang, Suet‐Kei Wu, Lucile Capuron

et al.

Psychiatric Annals, Journal Year: 2025, Volume and Issue: 55(2)

Published: Feb. 1, 2025

Major depressive disorder (MDD) and obesity are significant global health concerns with a strong bidirectional relationship. Gut microbiota dysbiosis has been implicated in both MDD obesity, characterized by alterations microbial diversity its metabolites. Omega-3 polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA), docosahexaenoic (DHA) have shown promise alleviating symptoms improving metabolic health. Diet plays crucial role shaping gut microbiota, omega-3 PUFAs emerging as potential therapeutic target. By modulating reducing inflammation, influencing neurotransmitter systems, may offer novel approach to treating obesity. This article will investigate the of relationship between depression via microbiome inflammation. Further investigation is needed establish optimal dosage supplementation for individuals comorbid [ Psychiatr Ann . 2025;55(2):e34–e39.]

Language: Английский

Citations

1
Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver DOI Creative Commons
Merve Çebi, Yusuf Yılmaz

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 14, 2025

In recent years, the prevalence of chronic liver diseases, particularly Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), has increased significantly. This upward trend is largely associated with lifestyle-related factors such as unhealthy dietary habits, physical inactivity, and various environmental influences. Among key elements contributing to pathogenesis MASLD, integrity intestinal epithelial barrier emerges a critical determinant, given its central role in maintaining immune homeostasis along gut-liver axis. Disruption this barrier, often driven by excessive consumption saturated fats refined carbohydrates combination low fiber intake, can lead microbial dysbiosis. imbalance gut microbiota triggers dysregulation promotes systemic inflammation, thereby exacerbating hepatic injury. review discusses contribution dysfunction development progression particular focus on how permeability may initiate sustain inflammation. Additionally, influence integrity, responses, inflammatory cascade addressed. A better understanding complex interplay between impairment, modulation, pathology offer valuable insights into MASLD pathophysiology contribute more targeted therapeutic strategies.

Language: Английский

Citations

0