The regulatory effects and mechanisms of plant food-derived bioactive components on gut barrier function and intestinal homeostasis: a comprehensive review DOI

Peichun Xie,

Zeliang Ma,

Xiaoshuang Yang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

The gut barrier, composed of physical, secretory, immunological, and biological components, serves as the first line defense against external threats. commensal microbiota not only functions a barrier to maintain intestinal homeostasis but also produces metabolites that regulate integrity. Increasing evidence suggests dysfunction is linked gastrointestinal diseases, autoimmune disorders, neurological conditions. Plant food-derived bioactive components exhibit diverse bioactivities, including ability modulate improve function, potentially preventing chronic diseases. This review explores mechanisms underlying disruption caused by drugs, diet, pathogenic infections, alcohol. Additionally, it provides comprehensive summary beneficial effects specific plant on function homeostasis, along with their mechanisms. By elucidating these interactions, this offers valuable insights for developing safer, more effective, affordable plant-based strategies prevent or mitigate dysfunction. Understanding role compounds in health may contribute novel dietary interventions aimed at strengthening defenses reducing risk diseases associated impairment.

Language: Английский

The regulatory effects and mechanisms of plant food-derived bioactive components on gut barrier function and intestinal homeostasis: a comprehensive review DOI

Peichun Xie,

Zeliang Ma,

Xiaoshuang Yang

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 27, 2025

The gut barrier, composed of physical, secretory, immunological, and biological components, serves as the first line defense against external threats. commensal microbiota not only functions a barrier to maintain intestinal homeostasis but also produces metabolites that regulate integrity. Increasing evidence suggests dysfunction is linked gastrointestinal diseases, autoimmune disorders, neurological conditions. Plant food-derived bioactive components exhibit diverse bioactivities, including ability modulate improve function, potentially preventing chronic diseases. This review explores mechanisms underlying disruption caused by drugs, diet, pathogenic infections, alcohol. Additionally, it provides comprehensive summary beneficial effects specific plant on function homeostasis, along with their mechanisms. By elucidating these interactions, this offers valuable insights for developing safer, more effective, affordable plant-based strategies prevent or mitigate dysfunction. Understanding role compounds in health may contribute novel dietary interventions aimed at strengthening defenses reducing risk diseases associated impairment.

Language: Английский

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