
Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 210 - 212
Published: March 1, 2025
Language: Английский
Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 210 - 212
Published: March 1, 2025
Language: Английский
Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(1), P. 8 - 10
Published: Jan. 1, 2025
Language: Английский
Citations
2Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(1), P. 6 - 7
Published: Jan. 1, 2025
Language: Английский
Citations
0Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 230 - 238
Published: March 1, 2025
Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production estrogen) without another pathological or physiological cause becomes one the most health issues in world. Vasomotor symptoms (VMS) is a hallmark menopause, occurring up 80 % women experiencing and persisting for over seven years with significant negative impacts on physical, psychological, social, overall wellbeing. Conventionally, menopause hormone therapy (MHT) considered effective therapeutic opinion many based fact as "deficiency estrogen"; however, ratio benefits risk highly debated always concern. Therefore, non-MHT agent focusing underlying pathophysiology VMS, such hypothalamus-pituitary-ovary axis becoming attractive. Based this concept, hypothalamus neural construct containing Kisspeptin (Kp) neurons median pre-optic area (POA) Kp-neurokinin B (NKB)-dynorphin (DYN) (KNDy neurons) infundibular nucleus identified thermoregulatory circultry involve normal reproduction menopause-associated VMS. The neurokinin 3 receptor (NK3R) antagonists applied VMS are enthusiasm big success. Fezolinetant best breakthroughs. Recent three randomized clinical trials (RCTs), including SKYLIGHT 1,2, 4 confirmed safety efficacy treating moderate-to-severe women. By contrast, MONGLIGHT RCTs East Asia population seemed controversial effect treatment, but there no doubt that issue also satisfied, contributing need more validate its diverse population. current review will summary recent advance new landscape management particularly focus fezolinetant product.
Language: Английский
Citations
0Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2025, Volume and Issue: 64(2), P. 210 - 212
Published: March 1, 2025
Language: Английский
Citations
0