Impact of ischemic preconditioning combined with aerobic exercise on 24-h ambulatory blood pressure in men with prehypertension and stage 1 hypertension DOI Creative Commons

Min-Hyeok Jang,

Daehwan Kim, Jean-Hee Han

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

Introduction A single bout of aerobic exercise is known to induce a temporary reduction in post-exercise blood pressure termed hypotension (PEH). Meanwhile, an ischemic preconditioning (IPC), series short ischemia-reperfusion intervention, has also shown antihypertensive effects showing potential nonpharmacologic intervention for hypertension. While the acute BP and IPC are individually well-investigated, it remains unclear if combining both interventions additive effect on PEH. Methods total twelve pre- or hypertensive men (six prehypertension, six stage 1 hypertension) underwent either 30 min at 50% VO 2peak (CON) before exercise, counterbalanced order. involved inflating cuffs thighs 200 mmHg 5 min, alternating between right left three cycles, totaling min. Brachial was measured during 1-h recovery whereas muscle oxygen saturation (SmO 2 ) from rectus femoris monitored using NIRs recovery. Heart rate variability (HRV) baroreflex sensitivity (BRS) together with head-up tilt test (at 0 50°) were pre-test, post-test, 24-h post-test. After completion each experiment, ambulatory (ABP) assess within window. Results heart responses did not differ conditions while SmO significantly elevated ( p = 0.004). There no difference HRV supine BRS. However, reduced titled BRS after found CON preserved similar pre-exercise value, extending post period 0.047). ABP monitoring revealed significant systolic sleep compared 0.046). Conclusion The present findings suggest that session results notable decrease ABP, particularly sleep, alone. This supplementary associated sustained BRS, persisting up 24 h contrast observed CON. Future studies warranted investigate long-term adaptations IPC.

Language: Английский

Remote ischemic preconditioning prevents high‐altitude cerebral edema by enhancing glucose metabolic reprogramming DOI Creative Commons
Rongrong Han,

Xiaoyan Yang,

Xunming Ji

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(9)

Published: Sept. 1, 2024

Abstract Aims Incidence of acute mountain sickness (AMS) ranges from 40%–90%, with high‐altitude cerebral edema (HACE) representing a life‐threatening end stage severe AMS. However, practical and convenient preventive strategies for HACE are lacking. Remote ischemic preconditioning (RIPC) has demonstrated effects on ischemia‐ or hypoxia‐induced cardiovascular cerebrovascular diseases. This study aimed to investigate the potential molecular mechanism application RIPC in preventing onset. Methods A hypobaric hypoxia chamber was used simulate environment 7000 meters. Metabolomics metabolic flux analysis were employed assay metabolite levels. Transcriptomics quantitative real‐time PCR (q‐PCR) gene expression Immunofluorescence staining performed neurons label cellular proteins. The fluorescent probes Mito‐Dendra2, iATPSnFR1.0, CMTMRos observe mitochondria, ATP, membrane cultured neurons, respectively. TUNEL detect quantify apoptotic cell death. Hematoxylin eosin (H&E) utilized analyze pathological changes, such as tissue swelling cortex samples. Rotarod test assess motor coordination balance rats. Oxygen–glucose deprivation (OGD) cells an vitro model hypoglycemia induced by animal experiments. Results We revealed causative perturbation glucose metabolism brain preceding edema. Ischemic treatment significantly reprograms metabolism, ameliorating apoptosis energy deprivation. Notably, improves mitochondrial ATP production through enhanced glucose‐coupled metabolism. In vivo studies confirm that alleviates edema, reduces hypoxia, dysfunction resulting Conclusions Our elucidates basis pathogenesis. provides new strategy reprogramming highlighting targeting neuroprotective interventions neurological diseases caused ischemia hypoxia.

Language: Английский

Citations

6
Mechanism, prevention and treatment of cognitive impairment caused by high altitude exposure DOI Creative Commons
Xin Chen, J K Zhang, Yuan Lin

et al.

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 4, 2023

Hypobaric hypoxia (HH) characteristics induce impaired cognitive function, reduced concentration, and memory. In recent years, an increasing number of people have migrated to high-altitude areas for work study. Headache, sleep disturbance, impairment from HH, severely challenges the physical mental health affects their quality life efficiency. This review summarizes manifestations, mechanisms, preventive therapeutic methods HH environment affecting function provides theoretical references exploring treating high altitude-induced impairment.

Language: Английский

Citations

13
Aerobic exercise training improves learning and memory performance in hypoxic-exposed rats by activating the hippocampal PKA–CREB–BDNF signaling pathway DOI Creative Commons
Siyang Luo, Lei Shi, Tong Liu

et al.

BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 21, 2025

Abstract Background This study aims to investigate the effects of aerobic exercise training on learning and memory (L&M) performance in rats exposed altitude hypoxia its relationship with hippocampal plasticity PKA–CREB–BDNF signaling pathway. Methods Male Sprague–Dawley were 14.2% or without 60 min non-weight-bearing swimming for 8 weeks. The L&M was evaluated using Morris water maze, mRNA expression PSD95, SYP, PKA, CREB, CBP, BDNF hippocampus detected. Results Chronic exposure significantly impaired reduced BDNF. Aerobic effectively reversed these changes by enhancing synaptic through activation Conclusion can alleviate decline caused exposure, possibly

Language: Английский

Citations

0
Hypoxic preacclimatization combining intermittent hypoxia exposure with physical exercise significantly promotes the tolerance to acute hypoxia DOI Creative Commons
Jiaxin Xie,

Shenwei Xie,

Zhifeng Zhong

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: April 3, 2024

Background: Both hypoxia exposure and physical exercise before ascending have been proved to promote high altitude acclimatization, whether the combination of these two methods can bring about a better effect remains uncertain. Therefore, we designed this study evaluate hypoxic preacclimatization combining intermittent (IHE) on tolerance acute screen optimal scheme among lowlanders. Methods: A total 120 Han Chinese young men were enrolled randomly assigned into four groups, including control group three experimental groups with 5-day rest, exercise, 3-day in hypobaric chamber, respectively. Main parameters for AMS incidence, mental capacity measured each participant chamber simulated 4500 m evaluation stage. The was compared between different schemes. Results: During stage, SpO 2 rest significantly higher than that ( p = 0.001 0.006, respectively). participants had lower HR controls 0.018). No significant differences incidence found while proportion headache symptom (moderate severe vs. mild) 0.002). VO max, other 0.033, < 0.001, 0.023, also digital symbol pursuit aiming test scores, shorter color selection reaction time 0.005, 0.004, Conclusion: Hypoxic IHE appears be efficient promoting hypoxia. Hypoxia duration moderate intensity are helpful improvement HR, relief symptoms, enhancement operation capacity.

Language: Английский

Citations

1
Gastrointestinal syndrome encountered during a train voyage to high altitudes: A 14-day survey of 69 passengers in China DOI Creative Commons
Yihui Chen, Xiaoqi Tang,

Zeng Xiong

et al.

Travel Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 59, P. 102718 - 102718

Published: April 5, 2024

The diagnosis and evaluation of the severity acute mountain sickness (AMS) continue to be problematic due a lack consensus on inclusion symptoms in scoring system. Recent investigations highlight significance gastrointestinal identifying this condition. However, specific associated with AMS have not been thoroughly elucidated previous studies, underlying risk factors remain inadequately comprehended.

Language: Английский

Citations

1
Assessment of Acute Mountain Sickness: Comparing the Chinese AMS Score to the Lake Louise Score DOI
Yu Wu, Wenqi Zhao, Bao Liu

et al.

High Altitude Medicine & Biology, Journal Year: 2024, Volume and Issue: 25(3), P. 164 - 173

Published: April 11, 2024

Wu, Yu, Wenqi Zhao, Bao Liu, Jianyang Zhang, Zhifeng Zhong, Simin Zhou, Jiaxin Xie, Yuqi Gao, Peng Li, and Jian Chen. Assessment of Acute Mountain Sickness: Comparing the Chinese Ams Score to Lake Louise Score.

Language: Английский

Citations

1
Ischämische Präkonditionierung verbessert Symptome bei akuter Höhenkrankheit DOI

Maddalena Angela Di Lellis

Deleted Journal, Journal Year: 2024, Volume and Issue: 01(01), P. 8 - 9

Published: Feb. 1, 2024

Eine ischämische Präkonditionierung unter ischämischen oder hypoxischen Bedingungen kann kardiovaskuläre und zerebrovaskuläre Erkrankungen verhindern. Die Rolle bei der Verbesserung Akklimatisierung Vorbeugung akuten Höhenkrankheit in großer Höhe ist jedoch noch unklar. Wu et al. untersuchten die Wirkung entfernten auf von Personen, einer großen ausgesetzt sind.

Citations

0
Preoperative hypoxic biomarkers and postoperative delirium in patients with obstructive sleep apnea DOI Creative Commons

Martin Breitkopf,

Elena Ahrens, Matthias Herrmann

et al.

Journal of Anesthesia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Purpose Postoperative delirium (POD) in patients with obstructive sleep apnea (OSA) is associated increased mortality and healthcare costs. In this study, we investigated the association of OSA risk, serum biomarkers for central nervous ischemia (S100B NSE), POD. Methods After research ethics approval, completed STOP BANG assessment before undergoing elective surgery. Blood was drawn S100B NSE measurement, cognitive performance tested using Montreal Cognitive Assessment (MoCA) at study admission postoperatively discharge. Delirium performed Nursing Screening Scale (NuDESC) Confusion Method (CAM). Results One hundred twenty-four enrolled were separated into three OSA-risk groups based on score testing (low n = 22; intermediate 67; high 35). Preoperative values risk (NSE ng/ml; mean [range]; low risk: 15.6 [9.2–44.3]; 21.8 [7.6–114.1]; 29.2 [10.1–151]; p 0.039). MoCA NuDESC assessments not different between groups. We found a decreasing incidence POD increasing (positive CAM: 18.1%, 12.0%; 11.5%, 0.043). However, no longer detectable complete case analysis. POD, postoperative ischemic biomarker Conclusion trend which robust Our results possibly support phenomenon hypoxic preconditioning.

Language: Английский

Citations

0
Impact of ischemic preconditioning combined with aerobic exercise on 24-h ambulatory blood pressure in men with prehypertension and stage 1 hypertension DOI Creative Commons

Min-Hyeok Jang,

Daehwan Kim, Jean-Hee Han

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 7, 2024

Introduction A single bout of aerobic exercise is known to induce a temporary reduction in post-exercise blood pressure termed hypotension (PEH). Meanwhile, an ischemic preconditioning (IPC), series short ischemia-reperfusion intervention, has also shown antihypertensive effects showing potential nonpharmacologic intervention for hypertension. While the acute BP and IPC are individually well-investigated, it remains unclear if combining both interventions additive effect on PEH. Methods total twelve pre- or hypertensive men (six prehypertension, six stage 1 hypertension) underwent either 30 min at 50% VO 2peak (CON) before exercise, counterbalanced order. involved inflating cuffs thighs 200 mmHg 5 min, alternating between right left three cycles, totaling min. Brachial was measured during 1-h recovery whereas muscle oxygen saturation (SmO 2 ) from rectus femoris monitored using NIRs recovery. Heart rate variability (HRV) baroreflex sensitivity (BRS) together with head-up tilt test (at 0 50°) were pre-test, post-test, 24-h post-test. After completion each experiment, ambulatory (ABP) assess within window. Results heart responses did not differ conditions while SmO significantly elevated ( p = 0.004). There no difference HRV supine BRS. However, reduced titled BRS after found CON preserved similar pre-exercise value, extending post period 0.047). ABP monitoring revealed significant systolic sleep compared 0.046). Conclusion The present findings suggest that session results notable decrease ABP, particularly sleep, alone. This supplementary associated sustained BRS, persisting up 24 h contrast observed CON. Future studies warranted investigate long-term adaptations IPC.

Language: Английский

Citations

0