Figshare, Journal Year: 2023, Volume and Issue: unknown
Published: Jan. 1, 2023
Additional file 1. Correlation of chronological age with DNA methylation using Horvath, Hannum, SkinandBlood, PhenoAge, and GrimAge clocks the methylation-based telomere length (TL) estimator.
Language: Английский
Health Expectations, Journal Year: 2024, Volume and Issue: 27(2)
Published: March 14, 2024
Abstract Background Long Covid is an emerging long‐term condition, with those affected raising concerns about lack of healthcare support. Objective We conducted a qualitative study to identify facilitators and barriers access for people Covid, aiming enhance our understanding the specific nature these how patient experiences may vary. Setting Participants In context Symptoms, Trajectory, Inequalities Management: Understanding Long‐COVID Address Transform Existing Integrated Care Pathways (STIMULATE‐ICP) Delphi study, nationally distributed online survey was conducted. Eight patients eight practitioners (HCP) were interviewed via telephone or video call. Framework analysis, sensitised by candidacy theory, used over four levels care. Results Three themes identified: (i) patients' efforts navigate pathways (ii) patient–HCP interaction (iii) service resources structural constraints. Barriers specialist care included long waiting times, communication gaps across services continuity in Facilitators collaborative, patient‐centred approaches, active role their blended approaches appointments. The perspectives both HCPs largely aligned. Discussion framework valuable seeking healthcare. Individuals perceived themselves as eligible care, but they often encountered obstacles obtaining expected level or, some cases, did not receive it at all. Our findings are discussed model through multiple processes identification, negotiation, permeability appearances health services. These seem be especially important new pathway relevant primary secondary Conclusions This highlights that despite interviews being two years after start COVID‐19 pandemic, still struggle healthcare, emphasising ongoing need provide equitable timely Covid. Patient Public Contribution People advised on all stages this research.
Language: Английский
Citations
19
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: April 4, 2024
Abstract Bacterial infections triggered by patient or healthcare worker contact with surfaces are a major cause of medically acquired infections. By controlling the kinetics tetrabutyl titanate hydrolysis and condensation during sol–gel process, it is possible to regulate content Ti 3+ oxygen vacancies (OVs) in TiO 2 , adjust associated visible light-induced photocatalytic performance anti-bacterial adhesion properties. The results have shown that was 9.87% at calcination temperature reaction system 300 °C pH 1.0, corresponding optimal hydrophilic formation hydrated layer on superhydrophilic surface provided resistance bacterial adhesion, preventing cross-contamination high-touch surfaces. excellent self-cleaning properties can be attributed synergistic effects high specific area nanoparticles, mesoporous structure, presence OVs. under light serve as basis for development new class materials.
Language: Английский
Citations
9
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111930 - 111930
Published: March 27, 2024
Language: Английский
Citations
6
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: Feb. 4, 2025
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0309855 - e0309855
Published: April 16, 2025
Objectives To identify factors associated with survival in patients admitted to the intensive care unit (ICU) for COVID-19 who used high-flow nasal cannula (HFNC) a tertiary hospital northern Peru during March May 2021. Methodology A retrospective observational cohort study was carried out, including medical records selected according established inclusion criteria. The dependent variable survival, measured days from admission discharge or death. Factors related demographic, clinical, laboratory, and imaging characteristics were investigated, as well treatment-related parameters variables use of HFNC. Hazard ratios (HR) estimated independent risk survival. Results Of 154 patients, mean age 58.29 years. most frequent comorbidities arterial hypertension (29.2%), diabetes mellitus (20.6%), obesity (17.4%). median time HFNC 5 (interquartile range: 3–9 days). It found that 32.2% required mechanical ventilation, 51.6% died. ventilation 15.1 ± 13.3 days. Survival 97.5% at 48 hours, 85% 7 days, 62% 14 16.3% end study. Variables decreasing users NFVC ≥ 60 years (HR = 2.23; 95% CI: 1.21–4.08), presence 1.87; 1.01–3.45), increased work breathing on 2.38; 1.31–4.35), ROX index (iROX) < 3.85 1.71; 1.01–2.93). Conclusions iROX mortality hazard 1.5 times, older than years, respiratory effort scale WOB 4 points more twice hazard. results this highlight importance early accurate assessment Identifying these can help clinicians make informed decisions prioritize interventions could potentially improve group patients.
Language: Английский
Citations
0
Clinical Epigenetics, Journal Year: 2023, Volume and Issue: 15(1)
Published: Nov. 28, 2023
Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such epigenetic alterations telomere attenuation reflect the biological process of aging. Epigenetic clocks have shown to be valuable tools measuring age various tissues samples. As such, these can determine accelerated aging time-to-mortality across tissues. Previous reports attrition acceleration following SARS-CoV-2 infection. However, effect on outcome (death/recovery) patients with acute respiratory distress syndrome (ARDS) not well investigated.
Language: Английский
Citations
10
Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2023, Volume and Issue: 22(1)
Published: Aug. 7, 2023
Since the beginning of COVID-19 pandemic, therapeutic options for treating have been investigated at different stages clinical manifestations. Considering particular impact in Americas, this document aims to present recommendations pharmacological treatment specific population.
Language: Английский
Citations
8
COVID, Journal Year: 2024, Volume and Issue: 4(2), P. 221 - 260
Published: Feb. 10, 2024
This review provides a comprehensive summary of evidence to explore the role and value differential diagnosis in management Acute Respiratory Infections (ARIs) through point-of-care (POC) rapid testing post-pandemic scenario, paying particular attention coronavirus disease 2019 (COVID-19), influenza, respiratory syncytial virus (RSV). The document builds on literature policies process validation feedback by group seven experts from Latin America (LATAM). Evidence was collected understand scientific policy perspectives ARIs POC testing, with focus countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, Peru. indicates that can serve improve ARI case management, epidemiological surveillance, research innovation, evidence-based decision-making. With multiple types tests available for POC, decisions regarding which use require consideration purpose, resources, test characteristics accuracy, accessibility, affordability, results turnaround time. Based understanding current situation, this set recommendations implementation LATAM, supporting decision-making guiding efforts broad range stakeholders.
Language: Английский
Citations
2
Published: Aug. 9, 2023
The COVID-19 virus is spread to the respiratory system by minute airborne particles in contrast large particle fomite transmission. Yet, an often-repeated health directive during pandemic was improve handwashing limit of virus. Persistent can aggravate obsessive-compulsive disorder (OCD), diminishing mental health. Given that unlikely control COVID-19, it pertinent determine if for eradicate increased incidence OCD and, as such, promoted negative This scoping review parameter, “handwashing, health, OCD”, conducted July 2023, searched six relevant databases. result related evident both those already diagnosed with and regarding new cases throughout duration pandemic. conclusion officials should update details their directives information becomes available a concerning concentrate on have been relaxed once known transmission improbable. likely would reduced improved
Language: Английский
Citations
2
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: March 28, 2024
Abstract Racial/ethnic differences are associated with the potential symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These may exist among children warrant further exploration. We conducted a retrospective cohort study for adolescents under age 21 from thirteen institutions RECOVER Initiative. The is 225,723 patients or COVID-19 diagnosis 677,448 without between March 2020 October 2022. compared minor racial/ethnic groups to Non-Hispanic White (NHW) individuals, stratified by severity during acute phase COVID-19. Within severe group, Asian American/Pacific Islanders (AAPI) had higher prevalence fever/chills respiratory symptoms, Hispanic showed greater hair loss cases, while Black (NHB) fewer skin comparison NHW patients. non-severe AAPI increased POTS/dysautonomia NHB more cognitive than In conclusion, related specific PASC pediatrics, these illness
Language: Английский
Citations
0